Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues was written by Khadake, Shivaji Narayan;Karamathulla, Shaik;Jena, Tapan Kumar;Monisha, Mohan;Tuti, Nikhil Kumar;Khan, Faiz Ahmed;Anindya, Roy. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Safety of 3,5-Dibromo-4-methoxybenzaldehyde This article mentions the following:
Marine sponges of the genus Suberea produce a variety of brominated tyrosine alkaloids which display a diverse range of biol. activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biol. active marine natural products as antibacterial compounds, we report here the synthesis and evaluation of the biol. activity of a panel of ianthelliformisamines and subereamine analogs using the literature-known acid-amine coupling reaction. Several derivatives of ianthelliformisamine were obtained by coupling Boc-protected polyamines with brominated aromatic acrylic acid derivatives followed by Boc-deprotection using TFA. The aromatic acrylic acid derivatives varied in bromine substitution and geometry of the double bond. Similarly, subereamine analogs were synthesized by employing the coupling reaction between various brominated phenylacrylic acids with com. available chiral amino ester derivatives followed by ester hydrolysis. These synthetic analogs were screened for antibacterial activity against both Gram-neg. (Escherichia coli) and Gram-pos. (Staphylococcus aureus) strains. Ianthelliformisamine derivative I showed bactericidal activity against Staphylococcus aureus with an IC50 value of 3.8μM (MIC = 25μM). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Safety of 3,5-Dibromo-4-methoxybenzaldehyde).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of 3,5-Dibromo-4-methoxybenzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary