Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions was written by Ma, Xiaoming;Meng, Suzhi;Zhang, Xiaofeng;Zhang, Qiang;Yan, Shenghu;Zhang, Yue;Zhang, Wei. And the article was included in Beilstein Journal of Organic Chemistry in 2020.Related Products of 85118-24-7 This article mentions the following:
Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot N-allylation and intramol. Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines I (R1 = Me, Et, i-Bu; R2 = H, 8-Me, 8-Cl, etc.; R3 = Me, Et, C6H5, etc.) and II (R1 = H, 8-Me, 9-MeO, 8-CF3; R2 = Me, Et, C6H5, etc.). The multicomponent reaction was combined with one-pot reactions to make a synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Related Products of 85118-24-7).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 85118-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary