Synthesis of New Serotonin 5-HT7 Receptor Ligands. Determinants of 5-HT7/5-HT1A Receptor Selectivity was written by Medina, Rocio A.;Sallander, Jessica;Benhamu, Bellinda;Porras, Esther;Campillo, Mercedes;Pardo, Leonardo;Lopez-Rodriguez, Maria L.. And the article was included in Journal of Medicinal Chemistry in 2009.Quality Control of N-(5-Bromopentyl)phthalimide This article mentions the following:
The synthesis of a new set of compounds of general structure, e.g., I, with structural modifications in the pharmacophoric elements of the previously reported lead UCM-5600 is reported. The new derivatives have been evaluated for binding affinity at 5-HT7 and 5-HT1A receptors. The influence of the different structural features in terms of 5-HT7/5-HT1A receptor affinity and selectivity was analyzed by computational simulations of the complexes between the obtained compounds and β2-based 3-D models of these receptors. The hydrochloride of compound I (HYD1 = 1,3-dihydro-2H-indol-2-one; spacer = -(CH2)4-; HYD2 + HYD3 = 3,4-dihydroisoquinolin-2(1H)-yl) exhibits high 5-HT7R affinity (Ki = 7 nM) and selectivity over the 5-HT1AR (31-fold), and has been characterized as a partial agonist of the human 5-HT7R. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Quality Control of N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary