Novel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling was written by Vishnumurthy, Kodumuru;Makriyannis, Alexandros. And the article was included in Journal of Combinatorial Chemistry in 2010.Application In Synthesis of Methyl 2-bromo-4-fluorobenzoate This article mentions the following:
Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogs from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogs bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Application In Synthesis of Methyl 2-bromo-4-fluorobenzoate).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application In Synthesis of Methyl 2-bromo-4-fluorobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary