Carbonylative synthesis of thiochromenones via palladium-catalyzed tert-butyl isocyanide insertion was written by Zhang, Fang-Ling;Chen, Zhen-Bang;Liu, Kui;Yuan, Qing;Jiang, Qing;Zhu, Yong-Ming. And the article was included in Synlett in 2018.Category: bromides-buliding-blocks This article mentions the following:
A flexible and efficient carbonylative synthesis of thiochromenones from the com. available materials by utilizing tert-Bu isocyanide as carbonyl source has been developed. This methodol. efficiently constructs thiochromenones I (R1 = H, 8-F, 7-Cl, etc.; R2 = C6H5, 4-CH3OC6H4, 3-thienyl, etc.; Y = C, N) in moderate to excellent yields with the advantages of wide range of substrates and being applicable to library synthesis. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Category: bromides-buliding-blocks).
3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary