Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist was written by Zuev, Dmitry;Michne, Jodi A.;Huang, Hong;Beno, Brett R.;Wu, Dedong;Gao, Qi;Torrente, John R.;Xu, Cen;Conway, Charles M.;Macor, John E.;Dubowchik, Gene M.. And the article was included in Organic Letters in 2005.COA of Formula: C8H6Br2O2 This article mentions the following:
A stereocontrolled racemic synthesis of conformationally restricted analogs of a potent CGRP receptor antagonist [i.e., N-[(1R)-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxamide] by novel functionalization of 2-substituted pyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted α-nitration of intermediate lactams established the required trans-configuration in the desired products. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1COA of Formula: C8H6Br2O2).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbonbromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C8H6Br2O2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary