Month: December 2022

Polarography of organomercury compounds. Ethyl α-bromomercuryphenylacetate and its derivatives was written by Beletskaya, I. P.;Butin, K. P.;Reutov, O. A.. And the article was included in Zhurnal Organicheskoi Khimii in 1967.Application In Synthesis of Ethyl (2-bromophenyl)acetate This article mentions the following:

Polarographic reduction of RCH(HgBr)CO2Et (I) was carried out in 50% aqueous MeOH at 25 ± 0.5° with various supporting electrolytes (S). Two half-wave potentials (E1/2 and E1/2′) were observed with associated diffusion currents (id and id’) (R, I concentration in millimoles/l., S, S normality, E1/2 in mv., id in μamp., E1/2′ in mv., id’ in μamp.): Ph 0.051, NaBF4, 0.1, 70, 0.065, 285, 0.082; Ph, 0.510, NaBF4, 0.1, 83, 0.750, 344, 0.770; Ph, 0.080, LiClO4, 0.1, 80, 0.140, 320, 0.190; Ph, 0.500, LiClO4, 0.1, 115, 0.850, 370, 0.850; Ph, 0.051, NaBF4, 0.1 (with 10-2M NaBr), 153, 0.070, 255, 0.080; Ph, 0.510, NaBF4, 0.1 (with 10-2M NaBr), 145, 0.830, 275, 0.890. Reduction in a buffered solution (0.05M Britton-Robinson buffer pH 7.0) with 0.1N KNO3 as S gave the following results (R, E1/2 in mv., and E1/2′ in mv.): m-BrC6H4, 25, 145; p-IC6H4, 40, 162; p-BrC6H4, 80, 177; p-ClC6H4, 25, 179; o-BrC6H4, 30, 128; p-FC6H4, 40, 197; H, 50, 220; m-MeC6H4, 75, 225; p-EtC6H4, 90, 224°; p-iso-PrC6H4, 130, 246; o-MeC6H4, 40, 180; m-tert-BuC6H4, 55, 257. Following reaction steps were proposed: I + e ⇄ RCH(Hg·)CO2Et → [RCH(CO2Et)]2Hg + Hg0, and [RCH(CO2Et)]2Hg + 2 e → 2RCH2CO2Et + Hg0. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Application In Synthesis of Ethyl (2-bromophenyl)acetate).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of Ethyl (2-bromophenyl)acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective alkylation of phenylhydrazine: a facile and efficient synthesis of 1-alkyl-1-phenylhydrazines was written by Lerch, Ulrich;Koenig, Johann. And the article was included in Synthesis in 1983.Computed Properties of C5H11BrO This article mentions the following:

Hydrazines 4-RC₆H₄NR¹NH₂ [R = H, Me, Cl; R¹ = C_1-8 alkyl, allyl, (CH₂)₄OMe, PhCH₂] were prepared Thus, MeI was added to PhNHNH₂ and NaNH₂ in THF at 10-14° in 2.5 h, and the mixture was stirred 1.5 h and worked up to give 89% PhNMeNH₂. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Computed Properties of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Micelle-Enabled Palladium Catalysis for Convenient sp²-sp³ Coupling of Nitroalkanes with Aryl Bromides in Water Under Mild Conditions was written by Brals, Jeremy;Smith, Justin D.;Ibrahim, Faisal;Gallou, Fabrice;Handa, Sachin. And the article was included in ACS Catalysis in 2017.Application In Synthesis of Methyl 4-bromo-2-fluorobenzoate This article mentions the following:

The efficacy of custom surfactant FI-750-M, designed to mimic polar solvents such as DMF and 1,4-dioxane, was demonstrated with the palladium-catalyzed sp²-sp³ coupling of nitroalkanes to aryl bromides using a heteroleptic palladium catalyst under unprecedentedly mild conditions. Optimized reaction conditions mostly provided good yields up to gram scale, with high selectivity and functional group tolerance for a wide scope of aryl bromides. Use of surfactant FI-750-M makes water the gross reaction medium and enables in-flask recycling. The behavior of the surfactant was elucidated with DLS and cryo-TEM measurements, and mechanistic studies have revealed the importance of the π-allyl ligand in the catalytic cycle. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Application In Synthesis of Methyl 4-bromo-2-fluorobenzoate).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of Methyl 4-bromo-2-fluorobenzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Molecular iodine in isopropenyl acetate (IPA): A highly efficient catalyst for the acetylation of alcohols, amines, and phenols under solvent-free conditions was written by Ahmed, Naseem;van Lier, Johan E.. And the article was included in Tetrahedron Letters in 2006.Recommanded Product: 35065-86-2 This article mentions the following:

Iodine in isopropenyl acetate (IPA) is a highly efficient catalyst for the acetylation of a variety of alcs., phenols, and amines under solvent-free conditions. Primary, secondary and tertiary alcs., amines, and mono to polyhydroxy phenols and anilines with electron donating or withdrawing substituents can be easily acetylated in good to excellent yield at 85-90°. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Recommanded Product: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of several MPP derivatives for ^99mTc-labelling and evaluated as potential 5-HT_1A receptor imaging agents was written by Yang, Wen Jiang;Lin, Yan;Zhang, Xian Zhong;Zhang, Jun Bo;Wang, Xue Bin. And the article was included in Science China: Chemistry in 2011.Recommanded Product: 954-81-4 This article mentions the following:

The (2-methoxyphenyl) piperazine (MPP) was selected as the functional group and conjugated to dithiocarbamate through different spacers. A series of new MPP derivatives (MPPnDTC, n = 2-6) were synthesized and radiolabeled with ^99mTc-nitrido core or ^99mTc-tricarboxyl core as potential 5-HT1A receptor imaging agents. All the six ^99mTc-labeled complexes were lipophilic and neutral. Biodistribution results showed that those radiotracers had moderate initial brain and hippocampus uptake. There have no significant relation was observed between the biol. properties of these tracers with the length of its carbon chain. The radioactivity concentrations of hippocampus of ^99mTcN-MPP2DTC, ^99mTcN-MPP3DTC, ^99mTcN-MPP4DTC, ^99mTcN-MPP5DTC, ^99mTcN-MPP6DTC and ^99mTc(CO)₃-MPP3DTC at 2 min post-injection time (p.i.) were 0.43, 1.15, 0.99, 1.04, 1.13 and 0.83 %ID/g, resp. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The β-cyclodextrin cationic derivatives containing residues of some pharmacologically important acids was written by Grachev, M. K.;Charaev, A. A.;Kurochkina, G. I.;Vasyanina, L. K.;Shmelev, V. N.;Nifant’ev, E. E.. And the article was included in Russian Journal of General Chemistry in 2010.COA of Formula: C42H63Br7O28 This article mentions the following:

The cationic derivatives of β-cyclodextrin containing residues of covalently bound pharmacol. important acids were obtained by alkylation of nucleophilic reagents with 6-halo-6-deoxy-β-cyclodextrin. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1COA of Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. COA of Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 1,2-Diamines from Vinyl Sulfonium Salts and Arylamines was written by Wang, Cheng;Liu, Biao;Shao, Zeyu;Zhou, Junqi;Shao, Andong;Zou, Liang-Hua;Wen, Jian. And the article was included in Organic Letters in 2022.Quality Control of 3-Bromo-5-chlorophenylamine This article mentions the following:

A procedure for the synthesis of 1,2-diamines from vinyl sulfonium salts and arylamines under mild conditions was developed. This present synthetic protocol not only obviates the need for a transition-metal catalyst and an oxidizing reagent but also features a broad substrates scope. The practicability of this protocol is demonstrated by the one-pot synthesis, a scale-up reaction, and transformations of the products to diverse N-heterocyclic compounds Mechanistic studies indicate that the formation of aziridine plays a key role during this diamination process. In the experiment, the researchers used many compounds, for example, 3-Bromo-5-chlorophenylamine (cas: 96558-78-0Quality Control of 3-Bromo-5-chlorophenylamine).

3-Bromo-5-chlorophenylamine (cas: 96558-78-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Quality Control of 3-Bromo-5-chlorophenylamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Novel synthesis of various orthogonally protected C^α-methyl-lysine analogues and biological evaluation of a Vapreotide analogue containing (S)-α-methyl-lysine was written by Banerjee, Souvik;Wiggins, Walker J.;Geoghegan, Jessie L.;Anthony, Catherine T.;Woltering, Eugene A.;Masterson, Douglas S.. And the article was included in Organic & Biomolecular Chemistry in 2013.Recommanded Product: 954-81-4 This article mentions the following:

Prochiral malonic diesters containing a quaternary carbon center have been successfully transformed into a diverse set of ^tBoc-Fmoc-α^2,2-methyl-lysine-OH analogs through chiral malonic half-ester intermediates obtained via enzymic (Pig Liver Esterase, PLE) hydrolysis. The variety of chiral half-ester intermediates, which vary from 1 to 6 methylene units in the side chain, are achieved in moderate to high optical purity and in good yields. The PLE hydrolysis of malonic diesters with various side chain lengths appears to obey the Jones’s PLE model according to the stereochem. configurations of the resulting chiral half-esters. The established synthetic strategy allows the construction of both enantiomers of α^2,2-methyl-lysine analogs, and a (S)-β^2,2-methyl-lysine analog from a common synthon by straightforward manipulation of protecting groups. Two different straightforward and cost effective synthetic strategies are described for the synthesis of α^2,2-methyl-lysine analogs. The described strategies should find significant usefulness in preparing novel peptide libraries with unnatural lysine analogs. A Vapreotide analog incorporating (S)-α^2,2-methyl-lysine was prepared However, the Vapreotide analog with (S)-α-methyl-α-lysine is found to lose its specific binding to somatostatin receptor subtype 2 (SSTR2). In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Exploring the Anticancer Activity of Functionalized Isoindigos: Synthesis, Drug-like Potential, Mode of Action and Effect on Tumor-Induced Xenografts was written by Wee, Xi Kai;Yang, Tianming;Go, Mei Lin. And the article was included in ChemMedChem in 2012.Recommanded Product: 14425-64-0 This article mentions the following:

Meisoindigo has been used as an indirubin substitute for the treatment of chronic myeloid leukemia (CML) for several years. In view of its poor solubility and erratic absorption, several investigations have focused on developing analogs with more desirable physicochem. profiles. Here, we investigated the structure-activity relationship (SAR) of meisoindigo with respect to its antiproliferative activity on leukemic K562 cells and found that appending a phenalkyl side chain onto the lactam NH resulted in analogs that retained good activity. Furthermore, analogs in which the Ph ring was substituted with a basic heterocycle were significantly more soluble than meisoindigo while retaining acceptable antiproliferative profiles. The most promising analog (E)-1-(2-(4-methylpiperazin-1-yl)ethyl)-[3,3′-biindolinylidene]-2,2′-dione (5-4) is more potent than meisoindigo across a panel of malignant cells, with at least 40 times greater solubility than meisoindigo, little or no tendency to aggregate in solution and capable of significantly extending the lifespans of animals with K562 induced xenografts. Mechanistically, it induced apoptotic cell death and disrupted the progression of K562 cells from the G₁ to G₂ phase. Taken together, our findings highlighted the feasibility of addressing the physicochem. deficits of the isoindigo scaffold by systematic modifications which was achieved without overt loss of growth inhibitory activity. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Recommanded Product: 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemotherapeutic treatment of infections caused by Trichomonas vaginalis V was written by Kovacs, Tibor. And the article was included in Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Medizinisch-Hygienische Bakteriologie, Virusforschung und Parasitologie, Originale in 1962.COA of Formula: C7H7BrN2O2 This article mentions the following:

Viozol (I), trichomycin (II), tritheon (III), Penotran (IV), and poly(1,8-diaza-10-hydroxyundecane-HCl) (V), S-n-dodecylisothiuronium iodide (VI), 3-acetamido-4-hydroxyphenylarsenobis-(thioglycolic acid) (VII) and VI + VII were tested for their effects upon T. vaginalis infections. Good results were obtained with I, IV, V, VI, and VII, as well as combinations of VI + VII when locally applied. Local and oral treatment with III brought about permanent recovery in 1/3 of the cases. II had little effect. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7COA of Formula: C7H7BrN2O2).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C7H7BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary