Month: December 2022

Synthesis of 7-aminoheptanoic acid hydrochloride was written by Xu, Juan-juan;Li, Jie-mei;Li, Xiao-zhu;Chen, Jia-shu. And the article was included in Xiandai Shipin Keji in 2010.Formula: C13H14BrNO2 This article mentions the following:

The synthesis of the target compound (i.e., 7-aminoheptanoic acid hydrochloride) was achieved by a sequence involving a reaction of dibromopentane with potassium phthalimide, formation of 2-(5-bromopentyl)-1H-isoindole-1,3(2H)-dione, reaction with propanedioic acid ester and formation of 2-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)pentyl]propanedioic acid 1,3-di-Et ester and a subsequent hydrolysis and decarboxylation. The product was obtained in 55% overall yield and the structure was confirmed by ¹H-NMR, LC-ELSD-UV-DAD-MS. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Formula: C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed/Promoted Cross-coupling of gem-Diborylalkanes with Nonactivated Primary Alkyl Halides: An Alternative Route to Alkylboronic Esters was written by Zhang, Zhen-Qi;Yang, Chu-Ting;Liang, Lu-Jun;Xiao, Bin;Lu, Xi;Liu, Jing-Hui;Sun, Yan-Yan;Marder, Todd B.;Fu, Yao. And the article was included in Organic Letters in 2014.Computed Properties of C13H14BrNO2 This article mentions the following:

The first copper-catalyzed/promoted sp³-C Suzuki-Miyaura coupling reaction of gem-diborylalkanes with nonactivated electrophilic reagents is reported. Not only 1,1-diborylalkanes but also some other gem-diborylalkanes can be coupled with nonactivated primary alkyl halides, offering a new method for sp³C-sp³C bond formation and, simultaneously, providing a new strategy for the synthesis of alkylboronic esters. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Asymmetric Negishi Cross-Coupling of Secondary Allylic Chlorides with Alkylzincs was written by Son, Sunghee;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2008.Product Details of 57293-19-3 This article mentions the following:

Complementing previous advances in allylation chem., an effective nickel/Pybox catalyst for regioselective asym. Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A₁. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Product Details of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of medium ring heterocycles using an intramolecular Heck reaction was written by Arnold, Leggy A.;Luo, Wenchen;Guy, R. Kiplin. And the article was included in Organic Letters in 2004.Name: Ethyl (2-bromophenyl)acetate This article mentions the following:

Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenz[b,f]azepine, -oxocine, and -thiocine and dibenz[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramol. Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from com. available starting materials. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Name: Ethyl (2-bromophenyl)acetate).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: Ethyl (2-bromophenyl)acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A convenient procedure for the formation of per(6-deoxy-6-halo)cyclodextrins using the combination of tetraethylammonium halide with [Et₂NSF₂]BF₄ was written by Liu, Xiaofeng;Cheng, Sen;Wang, Xiaolei;Xue, Weihua. And the article was included in Synthesis in 2013.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

A convenient and efficient procedure for the regioselective halogenation of the primary alcs. of cyclodextrins using the reagent combination of tetraethylammonium halide with [Et₂NSF₂]BF₄ is described. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rearrangement of the bromine atom in the demethylation of bromomethoxybenzoic acid. IV. 2-Bromoanisic acid and 3-bromoanisic acid was written by Tomita, Masao;Fujitani, Kazuyoshi. And the article was included in Yakugaku Zasshi in 1956.Recommanded Product: 74440-80-5 This article mentions the following:

2,4-Br(MeO)C₆H₃CO₂H (XI), needles, m. 197-8°, was synthesized from 4-O₂NC₆H₄Me or p-cresol as a raw material. Nitration of 3-BrC₆H₄OH gave 3,4-Br(O₂N)C₆H₃OH, m. 125-31°, which was reduced to 3,4-Br(H₂N)C₆H₃OH, m. 151°; this was diazotized and treated with CuCN yielding 2,4-Br(HO)C₆H₃CN (XII), m. 151°. XI (0.5 g.), 15 ml. PhCl, and 2 g. AlCl₃ heated 1.5 hrs. on a water bath and the product poured on ice and extracted with Et₂O gave 0.3 g. 2,4-Br(HO)C₆H₃CO₂H (XIII), needles, m. 206-8° (from water); the m.p. of XIII given as 151° by Hodgson and Jenkinson (cf. C.A. 22,949) was confirmed to be the m.p. of XII. XI (1 g.) and 7 ml. HBr-AcOH in a sealed tube heated 5 hrs. at 130° and 2 hrs. at 150°, the product concentrated, neutralized with NaHCO₃ to remove the acidic substance, extracted with Et₂O, stirred with NaOH, and the NaOH layer acidified with HCl and extracted with Et₂O gave 3-BrC₆H₄OH (benzoate, m. 84-5°) and a small amount of XIII, m. 206-8°. XI (0.5 g.) and 6 ml. HCl-AcOH in a sealed tube heated 12 hrs. at 150° gave 0.45 g. XI. 2,4-Br(MeO)C₆H₃CO₂Me (XIV), plates, m. 29°, (1 g.) and 7 ml. HBr-AcOH in a sealed tube heated and the product treated as usual gave 3-BrC₆H₄OH. Similarly, 3,4-Br(MeO)C₆H₃CO₂H gave 3,4-Br(HO)C₆H₃CO₂H, m. 106-7°. 3,4-Br(MeO)C₆H₃CO₂Me (0.5 g.) gave 0.3 g. 3,5,4-Br₂(HO)C₆H₂CO₂H, m. 253-7° (decomposition), and 0.1 g. 3,4-Br(HO)C₆H₃CO₂H, m. 175-7° (Me ester, m. 107°). In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Recommanded Product: 74440-80-5).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 74440-80-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and crystal structures of two new selenides bearing 3-hydroxyphthalimidine was written by Zhang, Wanxuan;Yu, Haitao;Meng, Jiben;Matsuura, Teruo. And the article was included in Journal of Molecular Structure in 2003.Safety of N-(5-Bromopentyl)phthalimide This article mentions the following:

The title compounds (I; n = 3, 5) were prepared and characterized by elemental and spectral analyses, and their structures were confirmed by x-ray single crystal diffraction. In both crystals strong hydrogen bonds (O-H···O) were observed In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Safety of N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stoichiometric Self-Assembly of Isomeric, Shape-Persistent, Supramacromolecular Bowtie and Butterfly Structures was written by Schultz, Anthony;Li, Xiaopeng;Barkakaty, Balaka;Moorefield, Charles N.;Wesdemiotis, Chrys;Newkome, George R.. And the article was included in Journal of the American Chemical Society in 2012.Synthetic Route of C10H8Br2O4 This article mentions the following:

Two novel macromol. constitutional isomers have been self-assembled from previously unreported terpyridine ligands in a three-component system. The terpyridine ligands were synthesized in high yields via a key Suzuki coupling. Restrictions of the possible outcomes for self-assembly ultimately provided optimum conditions for isolation of either a mol. bowtie or its isomeric butterfly motif. These isomers have been characterized by ESI-MS, TWIM-MS, ¹H NMR, and ¹³C NMR. Notably, these structural isomers have remarkably different drift times in ion mobility separation, corresponding to different sizes and shapes at high charge states. In the experiment, the researchers used many compounds, for example, Dimethyl 4,5-dibromophthalate (cas: 859299-66-4Synthetic Route of C10H8Br2O4).

Dimethyl 4,5-dibromophthalate (cas: 859299-66-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Synthetic Route of C10H8Br2O4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB) was written by Arikawa, Yasuyoshi;Nishida, Haruyuki;Kurasawa, Osamu;Hasuoka, Atsushi;Hirase, Keizo;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Imanishi, Akio;Kondo, Mitsuyo;Tarui, Naoki;Hamada, Teruki;Takagi, Terufumi;Takeuchi, Toshiyuki;Kajino, Masahiro. And the article was included in Journal of Medicinal Chemistry in 2012.Reference of 881676-32-0 This article mentions the following:

In our pursuit of developing a novel and potent potassium-competitive acid blocker (P-CAB), we synthesized pyrrole derivatives focusing on compounds with low log D and high ligand-lipophilicity efficiency (LLE) values. Among the compounds synthesized, the compound I exhibited potent H⁺,K⁺-ATPase inhibitory activity and potent gastric acid secretion inhibitory action in vivo. Its maximum efficacy was more potent and its duration of action was much longer than those of proton pump inhibitors (PPIs). Therefore, compound I (1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate, TAK-438) was selected as a drug candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Reference of 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and base strengths of some (ω-methoxyalkyl)silanes and -germanes was written by Bellama, J. M.;Gerchman, L. L.. And the article was included in Inorganic Chemistry in 1975.Category: bromides-buliding-blocks This article mentions the following:

The ethers MH3(CH2)nOMe (M = C, Si, Ge; n = 1-6) were prepared from the appropriate 1-haloalkyl methyl ethers. A comparison of their base strengths (proton affinities) as measured by the shift in the ir OH stretching frequency of MeOH on complexation with the ethers shows that some factor(s) other than inductive effects significantly influences the electron-donating ability of O in the Si and Ge hydrides when n = 1 and 2. At n = 3-6 the basicities of these ethers converge toward those of the C analogs. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Category: bromides-buliding-blocks).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary