Month: December 2022

Intermolecular Radical C(sp³)-H Amination under Iodine Catalysis was written by Bosnidou, Alexandra E.;Muniz, Kilian. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 28322-40-9 This article mentions the following:

Alkanes and aryl alkanes such as ethylbenzene underwent regioselective amination with sulfonamides such as trifluoromethanesulfonamide in the presence of I₂ using iodobenzene bis(4-bromobenzoate) as the stoichiometric oxidant in anhydrous dichloromethane under blue LED irradiation to yield N-sulfonyl benzylic and alkyl amines such as PhCH(NHTf)Me. The method was used to prepare aminated amino acids and racemic arylglycinates and β-aryl-β-alaninates as well as memantine, rasagiline, and racemic sertraline. The method was also used to prepare trans-2,5-disubstituted pyrrolidines by iodine-catalyzed photochem. amination of phenylalkanes with methanesulfonamide followed by intramol. amination in the presence of I₂ using phenyliodine bis(3-chlorobenzoate) as the stoichiometric oxidant; the method was also used to prepare the dibenzoazabicyclooctane anticonvulsant MK-801. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Halogenation. XXIII. Halogenation of fluorobenzene, o-, m- and p-fluorotoluenes was written by Varma, P. S.;Venkat Raman, K. S.;Nilkantiah, P. M.. And the article was included in Journal of the Indian Chemical Society in 1944.Product Details of 452-62-0 This article mentions the following:

PhF (I) (10 cc.) treated with 1 mol. Cl (II) and 0.5 g. Fe powder, with occasional shaking, yields p-chlorofluorobenzene (III), b. 130°, while with 2 mols. II, it gives III and a mixture of 2,4- and 3,4-dichlorofluorobenzenes, b. 169-75°. The same mixture is obtained from III with 1 mol. II. FC₆H₄Br (15 g.), 1 g. Fe powder and 4.5 cc. Br (IV), yield, upon refluxing for 8 hrs., 5.8 g. 3,4-dibromofluorobenzene, needles (alc.), m. 69°, and 2,4-dibromofluorobenzene (V), b₃₂ 103-5°, b₇₅₆ 214-16°. I, iodine and NaNO₂ in CCl₄ refluxed for 4 hrs. after adding fuming H₂SO₄ dropwise during 1 hr., give p-iodofluorobenzene (VI), light brown oil, b₇₅₈ 178-81°. Similarly, m-fluorotoluene (VII) yields 3-fluoro-6-iodotoluene, b₉ 138-9° and 3-fluoro-4-iodotoluene, b₉ 138-9°, and o-fluorotoluene (VIII) gives 2-fluoro-5-iodotoluene (IX), light yellowish, b₈ 85°, and 2-fluoro-6-iodotoluene (X), b₈ 114-16°. VI, upon refluxing at 200-20° for 6 hrs. with Cu bronze, gives 4,4′-difluorobiphenyl, m. 89°. II (1.3 mols.) bubbled through VIII and Fe powder for 5-6 hrs. yields X, b₇₅₂ 151-2°, which yields the corresponding benzoic acid, m. 159°, upon oxidation, and a product (XI), b₇₅₂ 157-9° found to be identical with the product (XII) obtained by treating diazotized 2-fluoro-5-aminotoluene (XIII) with CuCl. Both XI and XII give 2-fluoro-5-chlorobenzoic acid, m. 168°, upon oxidation. IV in CCl₄ added dropwise, under cooling, to VII in CCl₄, in the presence of Fe powder, yields, after standing overnight, 3-fluoro-4-bromotoluene, b₇₅₆ 169°, and 3-fluoro-6-bromotoluene, b₇₅₆ 177°, the latter giving 3-fluoro-6-bromobenzoic acid, needles, m. 151°, upon oxidation with alk. KMnO₄. Similarly, p-FC₆H₄Me yields 4-fluoro-3-bromotoluene, b₇₅₇ 174-7°, and 4-fluoro-3-bromobenzoic acid, white, m. 156°. VIII treated with fuming HNO₃ gives 2-fluoro-5- (XIV) and -6-nitrotoluenes. Reduction of XIV yields 2-fluoro-5-aminotoluene, brownish black, b₉ 85-6° (HCl salt, m. 220° (decomposition)), which upon diazotization and treatment with KI yields IX, b₉ 86-7°. 2-Fluoro-6-aminotoluene gives by the same process X, b₉ 117°. o-, m- and p-Fluorobenzyl iodides, b₈ 91°, b₁₂ 98° and b₉ 102-3°, resp., were obtained by refluxing the corresponding benzyl chloride or bromide with KI in acetone for 4-5 hrs. VII treated with 2 mols. II, followed by heating for 6 hrs. on a sand bath, gives m-fluorobenzyl chloride, b₇₅₆ 176°, and m-fluorobenzal chloride, b₇₅₆ 195-7°, while with IV it gives m-fluorobenzal bromide, b₈ 108-10°. Similarly, o- and m-fluorobenzal chlorobromides, b₇ 109-10°, and b₇₅₆ 228-30°, b₉ 111-13°, resp., were obtained from the corresponding fluorobenzyl bromide. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Product Details of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity was written by Betti, Marco;Catarzi, Daniela;Varano, Flavia;Falsini, Matteo;Varani, Katia;Vincenzi, Fabrizio;Pasquini, Silvia;di Cesare Mannelli, Lorenzo;Ghelardini, Carla;Lucarini, Elena;Dal Ben, Diego;Spinaci, Andrea;Bartolucci, Gianluca;Menicatti, Marta;Colotta, Vittoria. And the article was included in Journal of Medicinal Chemistry in 2019.Formula: C8H7BrO2 This article mentions the following:

A new series of amino-3,5-dicyanopyridines was synthesized and biol. evaluated in order to further investigate the potential of this scaffold to obtain adenosine receptor (AR) ligands. In general, the modifications performed have led to compounds having high to good human (h) A₁AR affinity and an inverse agonist profile. While most of the compounds are hA₁AR-selective, some derivatives behave as mixed hA₁AR inverse agonists/A_2A and A_2B AR antagonists. The latter compounds showed that they reduce oxaliplatin-induced neuropathic pain by a mechanism involving the alpha7 subtype of nAchRs, similar to the nonselective AR antagonist caffeine, taken as the reference compound Along with the pharmacol. evaluation, chem. stability of Me 3-(((6-amino-3,5-dicyano-4-(furan-2-yl)pyridin-2-yl)sulfanyl)methyl)benzoate I was assessed in plasma matrixes (rat and human), and mol. modeling studies were carried out to better rationalize the available structure-activity relationships. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Formula: C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intermolecular Hydroacylation: High Activity Rhodium Catalysts Containing Small-Bite-Angle Diphosphine Ligands was written by Chaplin, Adrian B.;Hooper, Joel F.;Weller, Andrew S.;Willis, Michael C.. And the article was included in Journal of the American Chemical Society in 2012.Name: 2-Bromo-4-(trifluoromethyl)benzaldehyde This article mentions the following:

Readily prepared and bench-stable rhodium complexes containing methylene bridged diphosphine ligands, viz. [Rh(C₆H₅F)(R₂PCH₂PR’₂)][BAr^F₄] (R, R’ = ^tBu or Cy; Ar^F = C₆H₃-3,5-(CF₃)₂), are shown to be practical and very efficient precatalysts for the intermol. hydroacylation of a wide variety of unactivated alkenes and alkynes with β-S-substituted aldehydes. Intermediate acyl hydride complexes [Rh(^tBu₂PCH₂P^tBu₂)H{κ²(S,C)-SMe(C₆H₄CO)}(L)]⁺ (L = acetone, MeCN, [NCCH₂BF₃]^–) and the decarbonylation product [Rh(^tBu₂PCH₂P^tBu₂)(CO)(SMePh)]⁺ have been characterized in solution and by X-ray crystallog. from stoichiometric reactions employing 2-(methylthio)benzaldehyde. Analogous complexes with the phosphine 2-(diphenylphosphino)benzaldehyde are also reported. Studies indicate that through judicious choice of solvent and catalyst/substrate concentration, both decarbonylation and productive hydroacylation can be tuned to such an extent that very low catalyst loadings (0.1 mol %) and turnover frequencies of greater than 300 h^-1 can be achieved. The mechanism of catalysis has been further probed by KIE and deuterium labeling experiments Combined with the stoichiometric studies, a mechanism is proposed in which both oxidative addition of the aldehyde to give an acyl hydride and insertion of the hydride into the alkene are reversible, with the latter occurring to give both linear and branched alkyl intermediates, although reductive elimination for the linear isomer is suggested to have a considerably lower barrier. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Name: 2-Bromo-4-(trifluoromethyl)benzaldehyde).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 2-Bromo-4-(trifluoromethyl)benzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of some organomercury salts of the type XC₆H₄CH(HgBr)CO₂Et was written by Beletskaya, I. P.;Artamkina, G. A.;Shevlyagina, E. A.;Reutov, O. A.. And the article was included in Zhurnal Obshchei Khimii in 1964.Recommanded Product: 2178-24-7 This article mentions the following:

O-BrC₆H₄CH₂CN refluxed in EtOH-concentrated H₂SO₄ 5 h. gave 77% o-BrC₆H₄CH₂CO₂Et (I), b₇ 128°, m. 34.5°. Similarly was prepared the m-isomer, 75%, b₂ 120-1°, n²⁰_D 1.5348, d₂₀ 1.3810. p-EtC₆H₄CH₂CO₂Et, b₄ 110°, 1.4970, 1.013, was prepared in 82% yield from the acid and EtOH. I in CCl₄ was brominated under an incandescent lamp and gave XC₆H₄CHBrCO₂Et (II) (X = o-Br), 50%, b₁ 107°, 1.5781, 1.7266. Similarly was prepared the m-isomer, 60%, b₃ 148-9°, 1.5712, 1.7010, and II (X = p-O₂N), 55%, b₄ 165°, 1.5580, -. Et p-ethylmandelate and PBr₃ in CHCl₃ at first with cooling, then 0.5 h. on a steam bath, gave 73% p-EtC₆H₄CHBrCO₂Et, b₄ 125°, 1.5350, 1.3227. Similarly were prepared 60% p-iso-Pr analog, b₆ 142°, 1.5260, 1.2800, and p-methoxy analog, 65%, b₃ 150°, 1.5500, 1.4050. Shaking II with Hg gave 51% p-MeC₆H₄CH(HgBr)CO₂Et (III), m. 70°, 50% o-bromo analog, m. 91°, 40% m-bromo analog, m. 69°, 70% p-Et analog, m. 74°, 68% p-nitro analog, m. 135°, and 89% p-iso-Pr analog, m. 95°. In case the product precipitated as an oil, indicating the formation of R₂Hg, the mixture was treated with HgBr₂ to effect conversion to RHgBr. If the preparation of III was run at 50-60°, the product was 60% (p-MeC₆H₄CHCO₂Et)₂, m. 151°. Similarly was obtained the p-ethylphenyl analog, 15%, m. 125°. The reaction of the p-anisyl member with Hg gave only a tar that was free of Hg. A previously reported substance (loc. cit.), m. 145°, was shown to be BrHgCH₂C₆H₄CH₂CO₂Et, rather than III. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Recommanded Product: 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological activity of pyridinium-type acetylcholinesterase inhibitors was written by Alptuezuen, Vildan;Kapkova, Petra;Baumann, Knut;Erciyas, Ercin;Holzgrabe, Ulrike. And the article was included in Journal of Pharmacy and Pharmacology in 2003.Category: bromides-buliding-blocks This article mentions the following:

A novel series of bispyridinium-type acetylcholinesterase (AChE) inhibitors derived from obidoxime, being active in the lower micromolar range, has been reported recently. According to the hypothesis that shorter pyridinium compounds should exhibit higher activity, a new series of compounds was synthesized that has 2,6-dichlorobenzyl, 2-chlorobenzyl and phthalimidomethyl moieties, resp., at one end of the mol. and that are systematically shortened from the contralateral end. The concentration inhibiting the AChE and butyrylcholinesterase (BChE) by 50% (IC50) was evaluated by means of Ellman’s test. Compounds characterized by a phenylpropyl residue at the contralateral end (3) were found to have IC50 values comparable with tacrine. In addition, the affinity of 3c toward the BChE was lower, indicating a lower degree of side effects. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cooperative heterodimer formation between per-guadinylated and carboxylated or phosphorylated cyclodextrins in DMSO and DMSO-water studied by NMR spectroscopy and micro-calorimetry was written by Fotiadou, Katerina;Thanassoulas, Angelos;Nounesis, George;Yannakopoulou, Konstantina. And the article was included in Supramolecular Chemistry in 2011.Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:

The anionic cyclodextrins (CDs), heptakis[6-(3-thiopropionate)-6-deoxy]-β-CD, heptakis[6-(thio-ethanoate)-6-deoxy]-β-CD and partially phosphorylated 6-(aminoethylphosphate)-6-deoxy-β-CD as triethylammonium salts, bpsp.NHEt3, bpse.NHEt3 and bphos.NHEt3, resp., interacted with the pos. charged picrate salt of heptakis[6-(guanidino)-6-deoxy]-β-CD, bguan.picrate, to form heterodimers as shown by NMR spectroscopic and micro-calorimetric isothermal titration calorimetry (ITC) titrations in solution Association constants, Ka (M^-1) in DMSO-d6 and in DMSO-d6-H2O (80/20, volume/volume) were: bguan.picrate/bpsp.NHEt3, 6.4 × 105 and 5.9 × 104; bguan.picrate/bpse.NHEt3, 4.2 × 104 and 1.2 × 104; ITC data in DMSO agreed with those above: bguan.picrate/bpsp.NHEt3, Ka = 4.7 ± 0.1 × 105 M^-1, ΔH = – 83.97 kJ mol^-1, ΔS = – 173.19 J mol^-1K^-1; bguan.picrate/bpse.NHEt3, Ka = 2.4 ± 0.2 × 105 M^-1, ΔH = – 88.49 kJ mol^-1 and ΔS = – 182.27 J mol^-1K^-1. Heterodimers are highly stable in DMSO and less stable in DMSO-H2O. Multivalency in the interactions is manifested by pos. cooperativity, neg. enthalpy of formation (ΔH) and sizeable neg. entropy (ΔS), in support of the development of well-ordered supramol. structures in solution In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electrochemical reduction of several ortho-substituted nitro-benzenes by controlled potentials was written by Le Guyader, Michel;Tallec, Andre;Legoff, Raymond. And the article was included in Compt. Rend. in 1964.Product Details of 74440-80-5 This article mentions the following:

Nitrobenzenes having an o-halo substituent are reducible, in acid media and with a Hg cathode, to the corresponding amines and hydroxylamines; the latter are capable of Gattermann rearrangement. The following results were obtained [compound reduced, temperature, electrolyte, electrode potential (mv. vs. calomel reference electrode) product obtained, m.p.]: 2-RC₆H₄NO₂ (I) (R = F), <20°, 0.5N H₂SO₄, -350, 2-RC₆H₄NHOH (II) (R = F), 90° (petr. ether); I (R = F), 25°, N H₂SO₄, -900, 2-RC₆H₄NH₂ (III) (R = F), — (Bz derivative m. 110°); I (R = F), 90°, 25% H₂SO₄, -100, 3,4-R(H₂N)C₆H₃OH (IV) (R = F), — (O,N-di-Bz derivative m. 170°); I(R = Cl), 25°, NH₂SO₄, -350, II(R = Cl),– (picrate m. 179°); I (R = Cl), 40°, 10% EtOH-N H₂SO₄, -850, III(R = Cl), — (Bz derivative m. 100°); I (R = Cl), 90°, 25% H₂SO₄, -100°, IV (R = Cl), 160° (O,N-di-Ac derivative m. 122°); I (R = Br), 20°, 10% EtOH-N H₂SO₄, -350, II (R = Br), — (HBr salt m. 170°); I (R = Br), 40°, 10% EtOHN H₂SO₄, -850, III (R = Br), — (Ac derivative m. 96°); I (R = Br), 90°, 50% H₂SO₄, -100, IV (R = Br), 153° (O,N-di-Ac derivative m. 125°); I (R = iodine), 20°, 50% EtOH-N H₂SO₄, -350, II (R = iodine), 60° (petr. ether); I (R = iodine), 93°, 20% H₂SO₄, -150, IV (R = iodine), 150°; 2-O₂NC₆H₄CO₂Et (V), 15°, 50% EtOH-N H₂SO₄, -250, II (R = EtO₂C) (VI), 77°; V, 15°, 15% EtOH-N H₂SO₄, -850, III (R = EtO₂C), — (Ac derivative m. 62°); VI, 60°, ≤2N H₂SO₄, -150, VII, 118°; VI, 80°, ≥5N H₂SO₄, -150, 2,5-H₂N(HO)C₆H₃CO₂H (VIII), 248° (under intermediate conditions, a mixture of VIII and its Et ester, m. 145°, was obtained); 2-O₂NC₆H₄CONH₂ (IX), 25°, N H₂SO₄, -350, VII, 118°; and IX, 25°, N H₂SO₄, -1100, 2-H₂NC₆H₄CO₂H, 145°. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Product Details of 74440-80-5).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Product Details of 74440-80-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

New oxidative reactions of monovinylsilanes with sulfonamides was written by Astakhova, Vera V.;Moskalik, Mikhail Yu.;Sterkhova, Irina V.;Shainyan, Bagrat A.. And the article was included in Journal of Organometallic Chemistry in 2022.Recommanded Product: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The reactions of sulfonamidation of functionally substituted vinylsilanes having Si-Ph, Si-Cl or Si-O bonds (triphenylvinylsilane, trimethoxy(vinyl)silane, trichlorovinylsilane, dichloromethylvinylsilane, tris(2-methoxyethoxy)vinylsilane) with trifluoromethanesulfonamide, arenesulfonamides and methanesulfonamide in the presence of (t-BuOCl + NaI) or N-bromosuccinimide proceed in different manner depending on the substrate, reagent, and oxidant. The formation of the products of halosulfonamidation, heterocyclization, halogenation, solvent interception and desilylation is observed In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The vinylogous Catellani reaction: a combined computational and experimental study was written by Yamamoto, Y.;Murayama, T.;Jiang, J.;Yasui, T.;Shibuya, M.. And the article was included in Chemical Science in 2018.Safety of 2-(2-Bromophenyl)propan-2-amine This article mentions the following:

In the presence of 5 mol% Pd(OAc)₂, 1 equivalent of norbornene, and K₂CO₃, the reaction of 4-iodo-2-quinolones with tertiary o-bromobenzylic alcs. produced the desired benzopyran-fused 2-quinolones in moderate to high yields. A Catellani-type mechanism involving vinylic C-H cleavage is proposed based on the results of control experiments and d. functional theory calculations In the experiment, the researchers used many compounds, for example, 2-(2-Bromophenyl)propan-2-amine (cas: 173026-23-8Safety of 2-(2-Bromophenyl)propan-2-amine).

2-(2-Bromophenyl)propan-2-amine (cas: 173026-23-8) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 2-(2-Bromophenyl)propan-2-amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary