Month: December 2022

Preparation and Properties of Phosphaethynes Bearing Bulky Aryl Groups with Electron-Donating Substituents at the Para Position was written by Toyota, Kozo;Kawasaki, Subaru;Yoshifuji, Masaaki. And the article was included in Journal of Organic Chemistry in 2004.Computed Properties of C8H8Br2 This article mentions the following:

Phosphaethynes bearing a 2,6-di-tert-butyl-4-(dimethylamino)phenyl, 2,6-di-tert-butyl-4-methoxyphenyl, or 2,6-di-tert-butylphenyl group were prepared A ³¹P NMR spectroscopic study of the chem. shifts indicated that electron-donating groups at the para position cause shifts to a higher field. Bathochromic shifts caused by the electron-donating groups were apparently observed in UV-visible spectra. The structure of 2-[2,6-di-tert-butyl-4-(dimethylamino)phenyl]-1-phosphaethyne was analyzed by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Computed Properties of C8H8Br2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Computed Properties of C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rhodium-Catalyzed Parallel Kinetic Resolution of Racemic Internal Allenes Towards Enantiopure Allylic 1,3-Diketones was written by Hilpert, Lukas J.;Breit, Bernhard. And the article was included in Angewandte Chemie, International Edition in 2019.HPLC of Formula: 14425-64-0 This article mentions the following:

A rare case of a parallel kinetic resolution of racemic 1,3-disubstituted allenes by means of a rhodium-catalyzed addition to 1,3-diketones furnishing enantiopure allylic 1,3-diketones is described. Mechanistic experiments demonstrate that the different allene enantiomers react in parallel to either the diastereomeric E- or Z-allylic 1,3-diketones with the same absolute configuration of the newly formed stereogenic center. A broad substrate scope demonstrates the synthetic utility of this new method. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0HPLC of Formula: 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration was written by Sallam, Asmaa A.;Ramasahayam, Sindhura;Meyer, Sharon A.;El Sayed, Khalid A.. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Recommanded Product: 57293-19-3 This article mentions the following:

Bioactive secondary metabolites originating from dibromotyrosine are common in marine sponges, such as sponges of the Aplysina species. Verongiaquinol (1), 3,5-dibromo-1-hydroxy-4-oxocyclohexa-2,5-diene-1-acetamide, and aeroplysinin-1 are examples of such bioactive metabolites. Previous studies have shown the potent antimicrobial as well as cytotoxic properties of verongiaquinol and the anti-angiogenic activity of aeroplysinin-1. The work presented herein shows the design and synthesis of dibromotyrosine-inspired phenolic ester and ether analogs with anti-angiogenic, anti-proliferative and anti-migratory properties and negligible cytotoxicity. Several analogs were synthesized based on docking experiments in the ATP binding site of VEGFR2 and their anti-angiogenic potential and ability to inhibit angiogenesis and prostate cancer proliferation, migration and invasion were evaluated using the chick chorioallantoic membrane (CAM) assay, MTT, wound-healing, and Cultrex BME cell invasion assay models, resp. Analogs with high docking scores showed promising anti-angiogenic activity in the CAM assay. In general, ester analogs proved to be of higher anti-migratory activity whereas ether analogs showed better anti-proliferative activity. These results demonstrate the potential of dibromotyrosines as promising inhibitory scaffolds for the control of metastatic prostate cancer proliferation and migration. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stereoselective Synthesis of New Conformationally Restricted Analogues of a Potent CGRP Receptor Antagonist was written by Zuev, Dmitry;Michne, Jodi A.;Huang, Hong;Beno, Brett R.;Wu, Dedong;Gao, Qi;Torrente, John R.;Xu, Cen;Conway, Charles M.;Macor, John E.;Dubowchik, Gene M.. And the article was included in Organic Letters in 2005.COA of Formula: C8H6Br2O2 This article mentions the following:

A stereocontrolled racemic synthesis of conformationally restricted analogs of a potent CGRP receptor antagonist [i.e., N-[(1R)-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinecarboxamide] by novel functionalization of 2-substituted pyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted α-nitration of intermediate lactams established the required trans-configuration in the desired products. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1COA of Formula: C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and synthesis of diheterocyclic compounds containing tetrazolinone and 1,2,4-triazole was written by Luo, Yan-Ping;Lin, Long;Yang, Guang-Fu. And the article was included in Journal of Heterocyclic Chemistry in 2007.Related Products of 61150-57-0 This article mentions the following:

A novel series of 1-(4-chlorophenyl)-4-{[5-(alkylthio)-4-phenyl-4H-1,2,4-triazol-3-yl] methyl}-1,4-dihydro-5H-tetrazol-5-ones I (R = Me, Et, H₂C:CHCH₂, PhCH₂, 2,6-F₂C₆H₃CH₂, etc.) was synthesized in good to excellent yields and the structures of the products were identified by ¹H NMR, ¹³C NMR, MS and elemental anal. The X-ray crystallog. of I (R = PhCH₂) indicated the presence of strong intermol. hydrogen bonds in the stacking interactions. The bioassay results showed that I (R = 3-MeC₆H₄CH₂) exhibited good insecticidal activities against T cinnabarinus at the dosage of 250 mg.L^-1. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and insecticidal activity of lignan analogs. Part 6. Synthesis and insecticidal activity of sesquilignan analogs with 2-alkyl-6-methoxy-3-(3,4-methylenedioxyphenyl)-1,4-benzodioxanyl group was written by Yamauchi, Satoshi;Taniguchi, Eiji. And the article was included in Bioscience, Biotechnology, and Biochemistry in 1992.Electric Literature of C23H26BrP This article mentions the following:

The methoxymethyl group of the 6-methoxy-2-methoxymethyl-3-(3,4-methylenedioxyphenyl)-1,4-benzodioxan-7-yl moiety of insecticidal lignans of Phryma was modified with several alkyl groups to evaluate the effect on activity of the substituents. The assay results make it evident that this activity was significantly modified by the chain length or bulkiness of the alkyl groups and that the oxygen atom of the methoxymethyl group was fairly important for enhancing the activity. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Electric Literature of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Microwave-assisted synthesis of azoniaspiro compounds using a novel catalyst, 1-aza-phenothiazine was written by Gupta, Archana;Sakhuja, Rajeev;Kushwaha, Khushbu;Jain, Subhash C.. And the article was included in Synthetic Communications in 2011.Computed Properties of C13H14BrNO2 This article mentions the following:

1-Aza-phenothiazine catalyzed the intramol. cyclization of N-(bromoalkyl)phthalimides in the presence of anhydrous K₂CO₃ to form spiro cyclic quaternary ammonium salts, namely azoniaspiro compounds, under microwave irradiation A novel and eco-friendly method was developed for the synthesis of azoniaspiro compounds, and the role of aza-phenothiazine as a catalyst in such reactions was established for the first time. In the future, this protocol can be extended to the synthesis of various substituted N-heterocycles by hydrolyzing the resulting azoniaspiro compounds In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Catalytic, Enantioselective, Intramolecular Carbosulfenylation of Olefins. Preparative and Stereochemical Aspects was written by Denmark, Scott E.;Jaunet, Alex. And the article was included in Journal of Organic Chemistry in 2014.Related Products of 28322-40-9 This article mentions the following:

The first catalytic, enantioselective, intramol. carbosulfenylation of isolated alkenes with aromatic nucleophiles is described. The combination of N-(phenylsulfenyl)phthalimide, a chiral selenophosphoramide derived from BINAM, and ethanesulfonic acid as a cocatalytic Bronsted acid induced an efficient and selective cyclofunctionalization of various alkenes (aliphatic and aromatic) tethered to a 3,4-(methylenedioxy)phenyl ring (e.g., I → II). Under these conditions, 6-(phenylthio)-5,6,7,8-tetrahydronaphthalenes are formed diastereospecifically in good yields (50-92%) and high enantioselectivities (71:29-97:3 er). E-Alkenes reacted much more rapidly and with much higher selectivity than Z-alkenes, whereas electron-rich alkenes reacted more rapidly but with comparable selectivity to electron-neutral alkenes and electron-deficient alkenes. The Bronsted acid played a critical role in effecting reproducible enantioselectivity. A model for the origin of enantioselectivity and the dependence of rate and selectivity on alkene structure is proposed along with a rationale for the site selectivity in reactions with mono-activated arene nucleophiles. Safety: procedures for safe handling and disposal of Tl- and As-containing compounds are provided. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Related Products of 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Triazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen was written by Wang, Yan’en;Rong, Ruixue;Chen, Hua;Zhu, Mengyuan;Wang, Binghe;Li, Xiaoliu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.COA of Formula: C12H16BBrO2 This article mentions the following:

Cell surface carbohydrates of the Lewis blood group antigens, Lewis X (Le^x), Lewis Y (Le^y), Lewis A (Le^a), and their sialylated derivatives, such as sialy Lewis X (sLe^x) and sialy Lewis A (sLe^a), play important roles in various recognition processes. These cell surface carbohydrates have also been associated with the development and progression of many types of cancers. Recently, we synthesized four anthracene-based fluorescent bisboronic acid sensors (compounds 2a-d) linked by ‘click’ chem. with tethers of different lengths to match the epitope of various Lewis group of sugars. Among the four compounds, 2a appears to have both high sensitivity and selectivity for Le^y among other carbohydrate antigens. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1COA of Formula: C12H16BBrO2).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C12H16BBrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A rational design of carbazole-based host materials with suitable spacer group towards highly-efficient blue phosphorescence was written by Yuan, Xiao-Dong;Liang, Jian;He, Yun-Chu;Li, Qian;Zhong, Cheng;Jiang, Zuo-Quan;Liao, Liang-Sheng. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2014.HPLC of Formula: 100189-84-2 This article mentions the following:

Two novel carbazole derivatives, 3,3′-(2,6-dimethyl-1,4-phenylene)bis(9-phenyl-9H-carbazole) (DMCz) and 3,3′-(2,3,5,6-tetramethyl-1,4-phenylene)bis(9-phenyl-9H-carbazole) (TMCz), are designed and synthesized as host materials for blue phosphorescent organic light emitting diodes (PHOLEDs). Both the materials possess sufficiently high glass transition temperatures and triplet energies for the blue dopant Ir-complex Ir(III) bis(4,6-(difluorophenyl)-pyridinato-N,C’)picolinate (FIrpic, 2.65 eV). The device using DMCz as the host material showed a better performance than that of TMCz with a maximum power efficiency of 36.0 ± 0.7 lm per W, a maximum current efficiency of 43.7 ± 0.6 cd per A and a maximum external quantum efficiency (EQE) of 18.5 ± 0.1%. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2HPLC of Formula: 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary