Month: December 2022

Kong, Shuai published the artcileFluorescently visualizing the penetration of anionic surfactants across cytoplasmic membrane and the subsequent damage on human cells, Product Details of C8H17Br, the publication is Environmental Science and Pollution Research (2022), 29(14), 20593-20602, database is CAplus and MEDLINE.

The extensive application of chem. synthesized anionic surfactants would cause serious pollution of water and increase health risk to humans. However, the adverse impact of anionic surfactant on human cells has never been systematically demonstrated. In this paper, a series of fluorescent anionic surfactants containing a varying length of alkyl chain from C8 to C18 and a fixed hydrophilic head of 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) were synthesized and utilized for visualizing the interaction between surfactants and cells. The obtained mols. exhibited blue fluorescence presenting a decreasing fluorescent intensity with the increasing length of alkyl chain from C8 to C18 while showed the same sequence of HPTS-C16>HPTS-C18>HPTS-C12>HPTS-C8 on either surface activity, cellular adsorption, or cytotoxicity. In opposite, HPTS which contained no hydrophobic chain and thus exhibited no surface activity showed no cellular adsorption and cytotoxicity. It seems that the ligand of the appropriate chain length (C16) onto the hydrophilic HPTS mols. could cause the largest surface activity, the most distinguished cellular adsorption as well as the most adverse cytotoxicity. As reflected by the dynamic fluorescent visualization, the surfactant mols. of HPTS-C16 initially bound with cell membrane and entered into the intracellular lumen before finally localized at the (ER) and damaged it into a swollen structure. It is most likely that the structure of hydrophobic chain could determine the surface activities of surfactants and hence affect their cellular uptake and cytotoxicity. This study could help us to understand the adverse impact of anionic surfactant on human cells and its correlation with the surface activities or, in another word, the hydrophobic chain length.

Environmental Science and Pollution Research published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Product Details of C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Petrov, A. D. published the artcileCondensation of pinacol dihalides with allyl chloride in the presence of magnesium, SDS of cas: 594-81-0, the publication is Zhurnal Obshchei Khimii (1955), 1982-6, database is CAplus.

A mixture of 100 g. (EtMeCCl)₂ and 152 g. CH₂:CHCH₂Cl was added dropwise to 48 g. Mg (for technique cf. C.A. 47, 3218d), with cooling after the reaction had started; after treatment with aqueous NH₄Cl and distillation of the product from Na, there was obtained a mixture of 2 products, resolved into 10% (CH₂:CHCH₂CMeEt)₂, b₇₆₀ 210-15°, n_D²⁰ 1.4620, d₂₀ 0.818, which hydrogenated over Raney Ni at 190° and 200 atm. H to the corresponding saturated compound, b. 216-18°, f.p. below -80°, n_D²⁰ 1.4440, d₂₀ 0.798. The condensation also gave 38% C₁₁ hydrocarbon, b₇₆₀ 178-80°, n_D²⁰ 1.4560, d₂₀ 0.802, which with 1% KMnO₄ gave a ketone, identified as MeCOEt, and AcCHMeCH₂CO₂H, identified as the Ag salt; thus the 2nd product is probably CH₂:CHCH₂CHMeCMe:CMeEt, formed through allylic rearrangement of the starting material. (Me₂CBr)₂, decompose 168-9°, prepared from the glycol and dry HBr, was condensed similarly with 200% excess CH₂:CHCH₂Cl with Mg in Et₂O at -20°, yielding a mixture of (CH₂:CHCH₂CMe₂)₂ and [Me₂C(OEt)]₂, b. 145-7°, which after hydrogenation over Raney Ni gave a 12:88 mixture of a hydrocarbon C₁₂H₂₆ and the above diether, which could not be separated

Zhurnal Obshchei Khimii published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, SDS of cas: 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ormerod, W. E. published the artcileGranules and other changes in phase-contrast appearance produced by chemotherapeutic agents in trypanosomes, COA of Formula: C20H18BrN3, the publication is British Journal of Pharmacology and Chemotherapy (1963), 21(2), 259-72, database is CAplus and MEDLINE.

The morphological changes produced by 4 series of organic trypanocidal drugs were studied by quant. and by qual. methods using phase-contrast and fluorescence microscopy. Basic drugs (hydroxystilbamidine, quinapyramine, and homidium) were absorbed rapidly into the region of the kinetoplast; acidic drugs (suramin and related compounds) did not affect this region. Faint granules, which were present in some trypanosomes before the administration of drugs, absorbed the drugs and increased in contrast relative to the cytoplasm. Hydroxystilbamidine, quinapyramine, and related compounds, and possibly also suramin produced addnl. granules which did not contain drug. These addnl. granules are similar to the granules (volutin granules) which occur in trypanosome infections (not treated with drugs) when trypanosomes are about to be cleared from the blood. Homidium did not produce addnl. granules.

British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, COA of Formula: C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Venkateswararao, Eeda published the artcileAnti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells, SDS of cas: 18928-94-4, the publication is Bioorganic & Medicinal Chemistry (2014), 22(13), 3386-3392, database is CAplus and MEDLINE.

To investigate the anti-proliferative effect of NF-κB inhibitor, a series of analogs of (E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one were prepared and evaluated for their NF-κB inhibition and anti-proliferative activity against various human cancer cell lines. Compounds (E)-1-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one and (E)-4-(3-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3-oxoprop-1-enyl)benzenesulfonamide showed good NF-κB inhibition as well as potent anti-proliferative activity. SAR studies showed that all the compounds with potent or moderate NF-κB inhibition displayed good anti-proliferative activity. All the analogs maintained a good correlation between their NF-κB inhibition and anti-proliferative activity though the extent is not directly proportional to each other.

Bioorganic & Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Goryaev, M. I. published the artcileSynthesis of cyclopentane carbocylic acids, HPLC of Formula: 18928-94-4, the publication is Trudy Instituta Khimicheskikh Nauk, Akademiya Nauk Kazakhskoi SSR (1967), 77-87, database is CAplus.

C5H9 = cyclopentyl throughout this abstract A homologous series of cyclopentanecarboxylic acids of the general type I was synthesized and their ir spectra studied. Grignard reaction between C5H9Br and CO2 yielded 45% I (n = 0), b2 83°, n20D 1.4535. Treatment of di-Et Na malonate with C5H9Br gave 60% di-Et cyclopentanemalonate, b3 130-2°, n20D 1.4430, converted into the free acid and decarboxylated to yield I (n = 1), b3 93°, n20D 1.4522. Grignard reagent prepared from 140 g. C5H9Br and 9 g. Mg was treated at -10° with 20 g. ethylene oxide in 35 ml. ether to yield a distillation fraction containing crude C5H9(CH2)2OH, brominated to give 71% C5H9(CH2)2Br, b19 75-7°, n20D 1.4860; treatment with KCN yielded 53% corresponding nitrile, b2-3 62-8°, n20D 1.4500; hydrolysis of this gave 65.4% I (n = 2), b2 96-7°, n20D 1.4563. Condensation of C5H9(CH2)2Br with di-Et Na malonate yielded 30% di-Et (2-cyclopentylethyl)malonate, b2 136-8°, n20D 1.4442, decarboxylation of which gave 90% I (n = 3), b7 145-50°, n20D 1.4518. Cyclopentanebutanol, b2 85-6°, n20D 1.4610, d2020 0.9033; C5H9(CH2)4Br, b17 110-12°, n20D 1.4820, d2020 1.1872; C5H9(CH2)4CN, b17 124-6°, n20D 1.4575; and I (n = 4), b2 124-8°, n20D 1.4595, d2020 0.9752, were obtained from C5H9(CH2)2Br and ethylene oxide as starting materials in 55, 64, 88, and 81% yields, resp. Reaction between C5H9(CH2)4Br and di-Et Na malonate yielded 49.3% di-Et (4-cyclopentylbutyl)malonate, which on decarboxylation gave 69.7% I (n = 5), b2 127-30°, n20D 1.4542, d2020 0.9520. A mixture of air and ozone was passed through a solution of 60 g. Me oleate in AcOEt until neutral to reaction with Br; to the cooled solution 4 g. Zn dust in 2 ml. H2O was added, followed by 36 g. Zn in small portions and 4 ml. H2O on completion of the reaction; the mixture was stirred until neutral to the KI-starch test and worked up to yield 70% Me 8-formyloctanoate (II), b2 113°, n20D 1.4380. Grignard reaction between C5H9(CH2)2Br and II yielded 20% Me 11-cyclopentyl-9-hydroxyundecanoate; C5H9(CH2)4Br and II gave 15% Me 13-cyclopentyl-9-hydroxytridecanoate. Extensive ir data were given.

Trudy Instituta Khimicheskikh Nauk, Akademiya Nauk Kazakhskoi SSR published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, HPLC of Formula: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kanth, Priyanka published the artcileInvestigation of mesomorphic, photophysical and gelation behavior in aroylhydrazone based liquid crystals: Observation of mesophase crossover phenomena, COA of Formula: C12H25Br, the publication is Journal of Molecular Liquids (2022), 117084, database is CAplus.

Five series of substituted aroylhydrazones having two alkoxy chains at 3- and 5- positions at amide end of the mol. have been synthesized; wherein each series differ from each other in terms of number and position of alkoxy chains at imine end. The compounds of first series with the single alkoxy chain at 4-position at imine end self-assembled into columnar hexagonal mesophase. The lower homologues of the series with alkoxy chains at 3- and 5- positions at imine end showed a transition from columnar hexagonal to columnar rectangular mesophase in cooling cycle while the higher homologues exhibited columnar hexagonal mesophase. The series with alkoxy chains at 3- and 4- positions exhibited columnar rectangular mesophase. All the homologues of series with alkoxy chains at 2-, 3- and 4- positions showed a transition from columnar rectangular to columnar oblique mesophase in cooling cycle. The series with alkoxy chains at 3-, 4- and 5- positions exhibited transition in columnar hexagonal mesophase. The mesophase crossover from one columnar mesophase to the other was found to be dependent on the chain length as well as on the temperature during the self-assembly process in these mols. The substitution pattern showed an influence on the photophys. properties. The number and position of alkoxy chains played a critical role in the formation of gel in these mols. These liquid crystalline gelators have application potential in organic optoelectronic functional materials and devices.

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, COA of Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wan, Yimei published the artcilePhotocatalytic 1,1-Hydrofluoroalkylation of Alkynes with a Concurrent Vicinal Acylation: An Access to Fluoroalkylated Cyclic Ketones, Category: bromides-buliding-blocks, the publication is Organic Letters (2019), 21(11), 4187-4191, database is CAplus and MEDLINE.

A visible-light-induced 1,1-hydrofluoroalkylation of alkynes with a concomitant vicinal acylation is developed using THF (THF) as the hydrogen atom source. Various fluoroalkylated cyclic ketones, such as indanones, chroman-4-ones, 2,3-dihydroquinolin-4(1H)-ones, and 3,4-dihydronaphthalen-1(2H)-ones, can be efficiently synthesized with excellent trans-diastereoselectivity. The reaction represents the first example of 1,1-hydrofluoroalkylation of alkynes, thus providing a novel method for the construction of fluoroalkanes.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C19H21N3O3S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cao, Jingjiao published the artcileOrdered Porous Poly(ionic liquid) Crystallines: Spacing Confined Ionic Surface Enhancing Selective CO₂ Capture and Fixation, Category: bromides-buliding-blocks, the publication is ACS Applied Materials & Interfaces (2019), 11(6), 6031-6041, database is CAplus and MEDLINE.

Porous poly(ionic liquid)s (PPILs) combine the features of porous materials, polymers, and ionic liquids (ILs) or their derivatives, but they are normally of amorphous structure with disordered pores. Here, we report the facile synthesis of ordered porous poly(ionic liquid) crystallines (OPICs, specialized as a kind of PPIL analogs) with diverse and adjustable framework IL moieties through the Schiff base condensation of IL-derived ionic salts and neutral monomers. Ternary monomer mixtures are employed to artistically control the chem. composition and pore configurations. Compact at. packing was achieved to give spacing confined ionic surface with strong CO₂ affinity. Through monomer control, OPICs exhibit high CO₂ uptakes with excellent CO₂/N₂(CH₄) selectivities and efficiently implement CO₂ fixation through catalyzing epoxides cycloaddition under down to ambient conditions.

ACS Applied Materials & Interfaces published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sharma, Vinay S. published the artcileUpper/lower rim functionalized calixarene based AIE-active liquid crystals with self-assembly behavior: Photophysical and electrochemical studies, Formula: C8H17Br, the publication is Journal of Molecular Liquids (2022), 118047, database is CAplus.

Four novel bowl-shaped aggregation-induced emission (AIE)-active liquid crystalline compounds based on calix[4]arene having upper/lower unit functionalized by amide group and carrying six peripheral alkoxy chains, I (R = n-Bu, n-hexyl, n-octyl, n-decyl), were prepared Their mesogenic, electrochem., and photoactive properties were extensively examined X-ray diffraction (XRD) studies showed columnar type self-assembly behavior of I possessing alkyl chains of varying lengths with D-A-π-D systems. The thermal study of all the materials was examined by DSC and TGA anal. Their electrochem. studies were identified by cyclic voltammetry. The synthesized materials showed light blue emission in solution as well as thin-film under long UV light. The supramol. amide-thiadiazole linked compounds displayed enantiotropic columnar mesophase with good thermal stability. This new class of upper functionalized three-dimensional supramol. materials exhibited AIE and stabilized the columnar hexagonal phase with a higher temperature range.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C13H9FO2, Formula: C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kode, Kranthi published the artcileRaman labeled nanoparticles: characterization of variability and improved method for unmixing, Synthetic Route of 518-67-2, the publication is Journal of Raman Spectroscopy (2012), 43(7), 895-905, database is CAplus and MEDLINE.

Raman spectroscopy can differentiate the spectral fingerprints of many mols., resulting in potentially high multiplexing capabilities of Raman-tagged nanoparticles. However, an accurate quant. unmixing of Raman spectra is challenging because of potential overlaps between Raman peaks from each mol., as well as slight variations in the location, height, and width of very narrow peaks. If not accounted for properly, even minor fluctuations in the spectra may produce significant error that will ultimately result in poor unmixing accuracy. The objective of our study was to develop and validate a math. model of the Raman spectra of nanoparticles to unmix the contributions from each nanoparticle allowing simultaneous quantitation of several nanoparticle concentrations during sample characterization. We developed and evaluated an algorithm for quant. unmixing of the spectra called narrow peak spectral algorithm (NPSA). Using NPSA, we were able to successfully unmix Raman spectra of up to seven Raman nanoparticles after correcting for spectral variations of 30% intensity and shifts in peak locations of up to 10 cm^-1, which is equivalent to 50% of the full width at half maximum (FWHM). We compared the performance of NPSA to the conventional least squares (LS) anal. Error in the NPSA is approx. 50% lower than in the LS. The error in estimating the relative contributions of each nanoparticle with the use of the NPSA are in the range of 10-16% for equal ratios and 13-19% for unequal ratios for the unmixing of seven composite organic-inorganic nanoparticles (COINs); whereas, the errors from using the traditional LS approach were in the range of 25-38% for equal ratios and 45-68% for unequal ratios. Here, we report for the first time the quant. unmixing of seven nanoparticles with a maximum root mean square of the percentage error (RMS%) error of less than 20%.

Journal of Raman Spectroscopy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary