Month: December 2022

Dhungana, Roshan K. published the artcileNi-catalyzed regioselective 1,2-dialkylation of alkenes enabled by the formation of two C(sp³)-C(sp³) bonds, Formula: C12H16BBrO2, the publication is Journal of the American Chemical Society (2020), 142(50), 20930-20936, database is CAplus and MEDLINE.

The authors disclosed a Ni-catalyzed vicinal difunctionalization of alkenes with benzyl halides and alkylzinc reagents, which produces products with two new alkyl-alkyl bonds. This alkene dialkylation is effective in combining secondary benzyl halides and secondary alkylzinc reagents with internal alkenes, which furnishes products with three contiguous all-carbon secondary stereocenters. The products can be readily elaborated to access complex tetraene, benzosuberene, and bicyclodecene cores. The reaction also features as the most efficient alkene difunctionalization process to date with catalyst loadings down to 500 ppm and the catalytic turnover number (TON) and turnover frequency (TOF) registering up to 2 x 10³ and 165 h^-1 at rt, resp.

Journal of the American Chemical Society published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Formula: C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nakazato, Ryosuke published the artcileFactors for the emission enhancement of dimidium in specific media such as in DNA and on a clay surface, Computed Properties of 518-67-2, the publication is Physical Chemistry Chemical Physics (2019), 21(41), 22732-22739, database is CAplus and MEDLINE.

Dimidium (3,8-diamino-5-methyl-6-phenylphenanthridinium: NH₂PhP) is a well-known fluorophore as a DNA probe, although its fluorescence enhancement mechanism is not clear. In this study, we investigated the fluorescence enhancement mechanism of NH₂PhP on a clay surface by observing the fluorescence behavior. Four systematically selected phenanthridinium derivatives (PDs): NH₂PhP, 3,8-bisdimethylamino-5-methyl-6-phenylphenanthridinium (NMe₂PhP), 5-methyl-6-phenylphenanthridinium (PhP) and 5-methylphenanthridinium (P) and synthetic clay were used as guest and host materials, resp. It was revealed that the suppression of hydrogen bonding with water (N-HOH or NH-OH₂) is the dominant factor for the fluorescence enhancement on the clay surface for NH₂PhP and NMe₂PhP. In addition, judging from the fluorescence enhancement for NH₂PhP, NMe₂PhP and PhP and no fluorescence enhancement for P on the clay surface, the suppression of rotation of the Ph ring was indicated to make a partial contribution to the fluorescence enhancement mechanism. Because the fluorescence enhancement behavior was quite similar on the clay surface and in DNA, the obtained results afford an important clue to discuss the fluorescence enhancement mechanism of NH₂PhP in DNA.

Physical Chemistry Chemical Physics published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Computed Properties of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sengupta, Debabrata published the artcileIsolation of a Bimetallic Cobalt(III) Nitride and Examination of Its Hydrogen Atom Abstraction Chemistry and Reactivity toward H₂, Application of Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Journal of the American Chemical Society (2020), 142(18), 8233-8242, database is CAplus and MEDLINE.

Room temperature photolysis of the bis(azide)cobaltate(II) complex [Na(THF)_x][(^ketguan)Co(N₃)₂] (^ketguan = [(tBu₂CN)C(NDipp)₂]^–, Dipp = 2,6-diisopropylphenyl) (3a) in THF cleanly forms the binuclear Co nitride Na(THF)₄{[(^ketguan)Co(N₃)]₂(μ-N)} (1). Compound 1 represents the 1st example of an isolable, bimetallic Co nitride complex, and it was fully characterized by spectroscopic, magnetic, and computational analyses. D. functional theory supports a Co^III=N=Co^III canonical form with significant π-bonding between the Co centers and the nitride atom. Unlike other Group 9 bridging nitride complexes, no radical character is detected at the bridging N atom of 1. Indeed, 1 is unreactive toward weak C-H donors and even co-crystallizes with a mol. of cyclohexadiene (CHD) in its crystallog. unit cell to give 1·CHD as a room temperature stable product. Notably, addition of pyridine to 1 or photolyzed solutions of [(^ketguan)Co(N₃)(py)]₂ (4a) leads to destabilization via activation of the nitride unit, resulting in the mixed-valent Co(II)/Co(III) bridged imido species [(^ketguan)Co(py)][(^ketguan)Co](μ-NH)(μ-N₃) (5) formed from intermol. H atom abstraction (HAA) of strong C-H bonds (BDE ~100 kcal/mol). Kinetic rate anal. of the formation of 5 in the presence of C₆H₁₂ or C₆D₁₂ gives a KIE = 2.5 ± 0.1, supportive of a HAA formation pathway. The reactivity of the authors’ system was further probed by photolyzing benzene/pyridine solutions of 4a under H₂ and D₂ atms. (150 psi), which leads to the exclusive formation of the bis(imido) complexes [(^ketguan)Co(μ-NH)]₂ (6) and [(^ketguan)Co(μ-ND)]₂ (6-D), resp., as a result of dihydrogen activation. These results provide unique insights into the chem. and electronic structure of late 3d metal nitrides while providing entryway into C-H activation pathways.

Journal of the American Chemical Society published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C7H5Br2F, Application of Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Silvi, Mattia published the artcileMerging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes, COA of Formula: C4H6BrFO2, the publication is Journal of the American Chemical Society (2017), 139(16), 5736-5739, database is CAplus and MEDLINE.

Vinyl boronates react with electron-deficient alkyl iodides in the presence of visible light to give boronic esters in which two new C-C bonds were created. The reaction occurs by radical addition of an electron-deficient alkyl radical to the vinyl boronate followed by electron transfer with another mol. of alkyl iodide, continuing the chain, and triggering a 1,2-metalate rearrangement. In a number of cases, the use of a photoredox catalyst enhances yields significantly. The scope of the radical precursor includes α-iodo ketones, esters, nitriles, primary amides, α-fluorinated halo-acetates and perfluoroalkyl iodides.

Journal of the American Chemical Society published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C10H16Br3N, COA of Formula: C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

James, Tony D. published the artcileNovel saccharide-photoinduced electron transfer sensors based on the interaction of boronic acid and amine, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (1995), 117(35), 8982-7, database is CAplus.

Two boronic acid systems, monoboronic acid 3 and diboronic acid 8, were synthesized. When saccharides form cyclic boronate esters with these boronic acids, the Lewis acid-base interaction between the boronic acid moiety and tertiary amine is strengthened; when saccharides form cyclic boronate esters with boronic acids the acidity of the boronic acid is enhanced. The strength of this acid-base interaction modulates the photoinduced electron transfer (PET) from the amine to anthracene. Both of these compounds show increased fluorescence at pH 7.77 through suppression of the photoinduced electron transfer from nitrogen to anthracene on saccharide binding, a direct result of the stronger boron-nitrogen bond. Compound 3 shows the typical selectivity of monoboronic acids towards saccharides. Compound 8 which has a cleftlike structure is particularly selective and sensitive for glucose due to the formation of an intramol. 1:1 complex between the two boronic acids and the 1,2- and 4,6-hydroxyls of glucose. This is the first example in which ditopic recognition of monosaccharides is achieved in a PET sensor system.

Journal of the American Chemical Society published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Azzam, Eid M. S. published the artcileInhibition of Sulfate-Reducing Bacteria by Para-amino-N -((1-Alkylpyridin-1-Ium Bromide)-4-Yl) Benzamide Surfactants and Surfactant-Coated Silver Nanoparticles, Related Products of bromides-buliding-blocks, the publication is Journal of Surfactants and Detergents (2022), 25(1), 125-131, database is CAplus.

In the present work, we report the antibacterial activity of silver nanoparticles (AgNP) coated with the surfactants para-amino-N-((1-decylpyridin-1-ium bromide)-4-yl) benzamide and para-amino-N-((1-dodecylpyridin-1-ium bromide)-4-yl) benzamide (P10 and P12, resp.). P10 and P12-coated AgNP were stable, as confirmed by UV-visible spectrophotometry, transmission electron microscopy, and other surface activity parameters. Both P10 and P12 and the coated AgNP formulations were investigated for their activity against sulfate reducing bacteria (SRB). Overall, our results showed the importance of coating AgNP with surfactants (P10 and P12) in the design and development of new biocides against SRB.

Journal of Surfactants and Detergents published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Thangarasu, Arun K. published the artcileDesign, synthesis, and preliminary immunopotentiating activity of new analogues of nojirimycin, Computed Properties of 111-83-1, the publication is Carbohydrate Research (2022), 108479, database is CAplus and MEDLINE.

Three new classes of nojirimycin analogs viz. N-alkyl with C₁-substituent (4-phenylbutyl), N-substituted 1-deoxynojirimycin and its congener Δ-lactam, and a 4-phenylbutyl-β-C-glycoside were designed and synthesized for immunol. studies. The resulting diverse compound library exhibited proliferation of B Cells and T cells induced by LPS and Con A, resp. The majority of the analogs augmented the secretion of IL-12 in dendritic cells and TNF-α secretion in murine peritoneal macrophages compared to LPS (10μg/mL). A deoxynojirimycin-triazole conjugate of phytosphingosine analog was superior in the responses mentioned above and exhibited nitric oxide response equal to LPS. In comparison to findings on its congeners with immunosuppressive action, early immunol. tests show that the novel nojirimycin analogs have immunopotentiating effect. Nojirimycin analogs offer tremendous potential in tuning the immunomodulatory activity of iminosugars by subtle to substantial structural variations.

Carbohydrate Research published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C20H12N2O2, Computed Properties of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nagrimanov, Ruslan N. published the artcileAdditive scheme of solvation enthalpy for halogenated aliphatic hydrocarbons at 298.15 K., Safety of 1-Bromododecane, the publication is Thermochimica Acta (2022), 179155, database is CAplus.

In this work, an additive scheme for the estimation of solvation enthalpy of halogenated aliphatic hydrocarbons in n-heptane was developed. The proposed structural fragments for halogen group contributions are dependent on the nature of neighboring atoms. A linear relationship between solvation and vaporization enthalpy at 298.15 K for mono- and di-α,ω-halogen aliphatic compounds was found. These relationships can be used for the quick estimation of standard vaporization and solution enthalpies at 298.15 K. Proposed approaches for estimation of solvation, solution and vaporization enthalpies at 298.15 K were verified by conventional methods. In most cases, absolute deviations between exptl. and estimated values for halogenated aliphatic hydrocarbons do not exceed 1-2 kJ mol^-1.

Thermochimica Acta published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Safety of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nagrimanov, Ruslan N. published the artcileAdditive scheme of solvation enthalpy for halogenated aliphatic hydrocarbons at 298.15 K., Product Details of C8H17Br, the publication is Thermochimica Acta (2022), 179155, database is CAplus.

In this work, an additive scheme for the estimation of solvation enthalpy of halogenated aliphatic hydrocarbons in n-heptane was developed. The proposed structural fragments for halogen group contributions are dependent on the nature of neighboring atoms. A linear relationship between solvation and vaporization enthalpy at 298.15 K for mono- and di-α,ω-halogen aliphatic compounds was found. These relationships can be used for the quick estimation of standard vaporization and solution enthalpies at 298.15 K. Proposed approaches for estimation of solvation, solution and vaporization enthalpies at 298.15 K were verified by conventional methods. In most cases, absolute deviations between exptl. and estimated values for halogenated aliphatic hydrocarbons do not exceed 1-2 kJ mol^-1.

Thermochimica Acta published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Product Details of C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Das, Biswanath published the artcileCopper-catalyzed coupling of imidazoles and pyrazoles with 1,1-dibromo-1-alkenes: a distinct approach for direct N-alkynylation of heteroarenes, SDS of cas: 25753-84-8, the publication is Tetrahedron Letters (2011), 52(48), 6497-6500, database is CAplus.

The direct N-alkynylation of heteroarenes, imidazoles, and pyrazoles with 1,1-dibromo-1-alkene has been carried out using [Cu(Phen)PPh₃Br] as catalyst and Cs₂CO₃ in DMSO at 80°. The products are formed in good to high yields (66-85%) within 3 h and the target compounds thus formed included 1-(2-phenylethynyl)-1H-benzimidazole, 1-(2-phenylethynyl)-1H-imidazole, 1-(2-phenylethynyl)-1H-pyrazole derivatives No side products could be detected.

Tetrahedron Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, SDS of cas: 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary