Month: December 2022

Chao, Rong published the artcileDesign, Semisynthesis, Insecticidal and Antibacterial Activities of a Series of Marine-Derived Geodin Derivatives and Their Preliminary Structure-Activity Relationships, Application In Synthesis of 76283-09-5, the publication is Marine Drugs (2022), 20(2), 82, database is CAplus and MEDLINE.

To enhance the biol. activity of the natural product geodin isolated from the marine-derived fungus Aspergillus sp., a series of new ether derivatives I [R = Et, 2-bromobenzyl, 2-chlorobenzyl, etc.] was designed and semisynthesized using a high-yielding one-step reaction. In addition, the insecticidal and antibacterial activities of all geodin congeners I were evaluated systematically. Most of these derivatives I showed better insecticidal activities against Helicoverpa armigera Hubner than Geodin. In particular, I [R = 2,3,4,5-tetrafluorobenzyl] showed potent insecticidal activity with an IC₅₀ value of 89μM, comparable to the pos. control azadirachtin (IC₅₀ = 70μM). Addnl., I [R = 2-chlorobenzyl, 2-fluorobenzyl, 3,5-difluorobenzyl, 2,3,4-trifluorobenzyl, 4-cyanobenzyl and 2-fluoro-3-chlorobenzyl] showed strong antibacterial activity against Staphylococcus aureus and Aeromonas salmonicida with MIC values in the range of 1.15-4.93μM. The preliminary structure-activity relationships indicated that the introduction of halogenated benzyl especially fluorobenzyl, into geodin and substitution of 4-OH was a key factors in increasing the insecticidal and antibacterial activities of geodin.

Marine Drugs published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Application In Synthesis of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bates, Craig G. published the artcileSynthesis of 2-Arylbenzo[b]furans via Copper(I)-Catalyzed Coupling of o-Iodophenols and Aryl Acetylenes, Computed Properties of 25753-84-8, the publication is Organic Letters (2002), 4(26), 4727-4729, database is CAplus and MEDLINE.

We report a copper(I)-catalyzed procedure for the synthesis of 2-arylbenzo[b]furans. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans in good to excellent yields. This method can tolerate a variety of functional groups, does not require the use of expensive additives, and is palladium-free.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Computed Properties of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bates, Craig G. published the artcileCopper-Catalyzed Synthesis of Vinyl Sulfides, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Organic Letters (2004), 6(26), 5005-5008, database is CAplus and MEDLINE.

We report a method for the synthesis of vinyl sulfides using the soluble copper(I) catalyst [Cu(phen)(PPh₃)₂]NO₃. The desired vinyl sulfides are obtained in good to excellent yields, with retention of stereochem. This protocol tolerates a wide variety of functional groups or substrates, is palladium-free, and does not require the use of expensive or air-sensitive additives.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Freytag, Karen published the artcileHybrid single-chain nanoparticles via the metal induced crosslinking of N-donor functionalized polymer chains, Name: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Polymer Chemistry (2017), 8(48), 7546-7558, database is CAplus.

A set of copolymers based on Bu acrylate and 4-vinylpyridine was synthesized with mol. weights ranging from 6000 to 70 000 g/mol and an amount of metal binding sites ranging from 3 to 22 mol%. These organosol. precursors with hydrophobic side chains were treated with Cu²⁺, Co²⁺, Ni²⁺, Zn²⁺, Fe²⁺, Mg²⁺, and Pd²⁺. The coordination of metal ions to pyridine moieties as versatile N-donors led to intrachain crosslinking and subsequent chain collapse. A set of 34 hybrid single-chain nanoparticles was prepd and their formation was monitored by dynamic light scattering and diffusion ordered NMR spectroscopy. The influence of mol. weight, mol. weight distribution, and amount of binding sites on size reduction during single-chain nanoparticle formation was discussed in the context of models given in the literature. An indication for the dependency of size reduction on the coordinative bond strength was given. Selected crosslinking metal centers were analyzed by theor. investigations. A significant freedom for the coordination geometry which can induce chain collapse was revealed.

Polymer Chemistry published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Name: 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Niu, Ben published the artcilePhotoredox Polyfluoroarylation of Alkyl Halides via Halogen-Atom-Transfer, Recommanded Product: 1-Bromododecane, the publication is Organic Letters (2022), 24(3), 916-920, database is CAplus and MEDLINE.

The first polyfluoroarylation of unactivated alkyl halides RX (R = n-nonyl, cyclohexyl, adamantan-1-yl, 1-[(thiophen-2-yl)carbonyl]piperidin-4-yl, etc.; X = I, Br) e.g., I via halogen-atom-transfer process was described. This method converts primary, secondary, and tertiary alkyl halides into the resp. polyfluoroaryl compounds e.g., 3-(perfluorophenyl)butyl 4-methoxybenzoate in good yields in the presence of amide, carbamate, ester, aromatic and sulfonamide moieties including derivatives of complex bioactive mols. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after a halogen-atom-transfer.

Organic Letters published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Hui published the artcileSynthesis and characterization of poly(N-arylcarbazole-alt-aniline) copolymers as blue-emitting host matrix for polymer light-emitting diodes, Quality Control of 946491-48-1, the publication is Molecular Crystals and Liquid Crystals (2006), 95-107, database is CAplus.

Thermally stable and solution-processable poly(N-arylcarbazole-alt-aniline) copolymers with high structural integrity were synthesized in good yields via palladium-catalyzed polycondensation of aniline with corresponding N-arylcarbazole monomers such as N-(2-ethylhexyloxyphenyl)-3,6-dibromocarbazole, bis[6-bromo-N-(2-ethylhexyloxyphenyl)carbazole-3-yl] and N-(4-(2-ethylhexyl)-3,5-dibromomethylene-phenyl)carbazole, resp. The optical and electrochem. properties of these copolymers were measured and compared with those of poly(N-alkylcarbazole-alt-aniline) copolymer. All synthesized poly(N-arylcarbazole-alt-aniline) copolymers showed maximum UV-Vis absorption peaks at around 300 nm in THF solution, and exhibited maximum photoluminescence peaks in the blue emission range from 430 to 460 nm. Poly(N-arylcarbazole-alt-aniline) copolymers had a wider band gap energy than poly(N-alkylcarbazole-alt-aniline) copolymers.

Molecular Crystals and Liquid Crystals published new progress about 946491-48-1. 946491-48-1 belongs to bromides-buliding-blocks, auxiliary class OLED Materials,Red Fluorescence Dopants, name is 3,6-Dibromo-9-[4-(2-ethylhexyloxy)phenyl]-9H-carbazole, and the molecular formula is C44H28ClFeN4, Quality Control of 946491-48-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Hui published the artcileGreen and Red Electrophosphorescent Devices Consisting of Cabazole/Triarylamine-Based Polymers Doped with Iridium Complexes, Related Products of bromides-buliding-blocks, the publication is Molecular Crystals and Liquid Crystals (2007), 279-291, database is CAplus.

Two types of polymers were synthesized such as poly[N-(2-ethylhexyl)carbazole-alt-N-(4-aminophenyl)carbazole] (PECAC) and poly[N-(2-ethylhexyloxy-phenyl) carbazole-alt-N-(4-aminophenyl)carbazole] (PEPCAC). These polymers are designed to have carbazole groups with wide band gap and a triarylamine moiety with a hole transporting property. Green and red phosphorescent polymer light emitting diodes (PhPLEDs) were fabricated with an emitting layer consisting of either PECAC or PEPCAC as a host matrix with suitable iridium complexed, Ir(ppy)₃ as a green or IR-PIQCH as a red dopant, resp. Red PhPLEDs doped with IR-PIQCH exhibited maximum EL emission peaks at 620 nm with higher luminescence and lower driving voltage, due to effective energy transfer from host polymers to IR-PIQCH red dopant. Based on HOMO and LUMO levels of the polymers and Ir(ppy)₃, however, the synthesized polymers could not be served as suitable host polymers for Ir(ppy)₃ green dopant. Ir(ppy)₃ doped PhPLEDs exhibited red shift and wide range of EL emission.

Molecular Crystals and Liquid Crystals published new progress about 946491-48-1. 946491-48-1 belongs to bromides-buliding-blocks, auxiliary class OLED Materials,Red Fluorescence Dopants, name is 3,6-Dibromo-9-[4-(2-ethylhexyloxy)phenyl]-9H-carbazole, and the molecular formula is C8H17Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bradley, Mildred J. published the artcileThe chemistry of Borazine. II. The synthesis of N,N’,N”-trimethyl-B,B’,B”-trialkoxyborazines and N,N’,N”-trimethyl-B,B’,B”-triphenoxyborazine, COA of Formula: C5H12BrO3P, the publication is Journal of the American Chemical Society (1959), 2635-8, database is CAplus.

cf. C.A. 53, 3240a. When alkali alkoxides or phenoxides reacted with N,N’,N”-trimethyl-B,B’,B”-trichloroborazine (I) in dry benzene, the Cl on the B were replaced by alkoxy or phenoxy groups. Thus, 0.45 mole I in 100 ml. benzene was treated during 2 hrs. with 0.15 mole Na alkoxide, the mixture refluxed 8-12 hrs., stirred over-night, concentrated in vacuo, and the residue distilled The best yields were obtained at exact stoichiometry. The products reacted immediately with either water or alcs. The following were prepared: N,N’,N”-trimethyl-B,B’,B”-trimethoxyborazine, b_0.07 62-65°, n²³_D 1.4610; N,N’,N”-trimethyl-B,B’,B”-triethoxyborazine, b_0.10 79.5-80.5%, n^22.5_D 1.4540; N,N’,N”-trimethyl-B,B’,B”-triisopropoxyborazine, b_0.10 85-87°, n²³_D 1.4460; N,N’,N”-trimethyl-B,B’,B”-tripropoxyborazine, b_0.15 101-3°, n²²_D 1.4561; N,N’,N”-trimethyl-B,B’,B”-tributoxyborazine, b_0.30 130-4°, n²³_D 1.4572; N,N’,-N”-trimethyl-B,B’,B”-tri-tert-butoxyborazine, b_0.52 120-5°, m. 84-7°; N,N’,N”-trimethyl-B,B’,B”-triphenoxyborazine, b_0.07 185-7°, m. 81-4°.

Journal of the American Chemical Society published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, COA of Formula: C5H12BrO3P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ames, James R. published the artcileMode of action of antiprotozoan agents. Electron transfer and oxy radicals, Product Details of C20H18BrN3, the publication is Life Sciences (1987), 41(16), 1895-902, database is CAplus and MEDLINE.

Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressure from redox cycling involving oxygen is believed to be an important mode of action by the medicinal agents. Literature data contribute support.

Life Sciences published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Product Details of C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Marton, Daniele published the artcilePreparation of Benzylstannanes by Zinc-Mediated Coupling of Benzyl Bromides with Organotin Derivatives. Physicochemical Characterization and Crystal Structures, Category: bromides-buliding-blocks, the publication is Organometallics (1996), 15(6), 1645-50, database is CAplus.

Benzyltrialkyl- and benzyltriphenylstannanes were easily prepared in a 1-pot synthesis via coupling reaction of benzyl bromide derivatives (C₆H₅CH₂Br and XYC₆H₃CH₂Br, X = H, Y = o-, m-, p-CH₃, o-, m-, p-F, o-, m-Cl, and p-Br; X = o-F, Y = p-Br) with R₃SnCl compounds (R = Et, Pr, Bu, and Ph) in THF/H₂O (NH₄Cl) medium mediated by Zn powder. Such coupling also occurs with (Bu₃Sn)₂O. Dibenzyldibutylstannane (15) was prepared by reaction of benzyl bromide with Bu₂SnCl₂ or (Bu₂SnCl)₂O, and (2-naphthylmethyl)tributylstannane (14) by reaction of 2-(bromomethyl)naphthalene with Bu₃SnCl. ¹³C- and ¹¹⁹Sn-NMR data are reported for all compounds, and Moessbauer data for the benzyltributylstannanes and benzyltriphenylstannanes. The crystal structures of Ph₃SnBn, with Bn = o- (17) and m-ClC₆H₅CH₂ (18) and o- (20) and m-FC₆H₅CH₂ (21) were determined

Organometallics published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary