Month: December 2022

Gao, Ya published the artcileDefluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base, Application In Synthesis of 849062-12-0, the publication is Advanced Synthesis & Catalysis (2022), 364(13), 2241-2247, database is CAplus.

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.

Advanced Synthesis & Catalysis published new progress about 849062-12-0. 849062-12-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Bromo-5-methoxyphenyl)boronic acid, and the molecular formula is C7H8BBrO3, Application In Synthesis of 849062-12-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deng, Mengyu published the artcileTricolor core/shell polymeric ratiometric nanosensors for intracellular glucose and oxygen dual sensing, Related Products of bromides-buliding-blocks, the publication is Sensors and Actuators, B: Chemical (2019), 437-444, database is CAplus.

Monitoring cell metabolism is crucial for understanding cell life activity and cytopathic mechanism. Glucose and oxygen are very important parameters for cell metabolism In this work, core/shell nanomaterials as novel tricolor ratiometric luminescence nanosensors were prepared for real-time monitoring of intracellular oxygen and glucose levels. The nanosensors were achieved by covalently embedding of red emitting oxygen probes and yellow emitting reference probes into the hydrophobic cores and covalently grafting blue emitting glucose probes onto hydrophilic shells. This system realized simultaneous detection of glucose and oxygen through two different luminescent signals without enzyme assistance, and the two kinds of detection signals didn′ t interfere with each other. The nanosensors could sensitively detect glucose in the range of 0.01 to 5.0 mM and simultaneously detect dissolved oxygen in the range of 0.05 to 39.3 mg/L, indicating the suitableness for intracellular glucose and oxygen monitoring. Because of the small sizes (< 60 nm), biocompatible core-shell structures, covalently imparted dye leaking-free construction of the nanosensors, these nanomaterials showed good cell permeability and low cytotoxicity. Cell imaging and intracellular sensing of the nanosensors were studied by confocal luminescence microscopy. Hela cells stained with the nanosensors showed an increase in blue emission when glucose was added and an increase in red emission when oxygen was reduced. While, the yellow emission from the reference probes was not affected by glucose or oxygen. This work is expected to lead to the design of intracellular glucose and oxygen sensors, and can be extended to other multiple sensors in biol. systems.

Sensors and Actuators, B: Chemical published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zuo, Minzan published the artcileMultiresponsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery, HPLC of Formula: 166821-88-1, the publication is Small (2018), 14(38), n/a, database is CAplus and MEDLINE.

A closed-loop “smart” insulin delivery system with the capability to mimic pancreatic cells will be highly desirable for diabetes treatment. This study reports a multiple stimuli-responsive insulin delivery platform based on an explicit supramol. strategy. Self-assembled from a well-designed amphiphilic host-guest complex formed by pillar[5]arene and a diphenylboronic acid derivative and loaded with insulin and glucose oxidase, the obtained insulin-GOx-loaded supramol. vesicles can selectively recognize glucose, accompanied by the structure disruption and efficient release of the entrapped insulin triggered by the high glucose concentration as well as the in situ generated H₂O₂ and acid microenvironment during the GOx-promoted specific oxidation of glucose into gluconic acid. Moreover, such a “smart” supramol. theranostic nanoplatform is able to function as both a glucose sensor and a controlled insulin delivery actuator. In vivo experiments further demonstrate that this smart supramol. nanocarrier shows fast response to hyperglycemic circumstances and can effectively regulate the glucose levels in a mouse model of type I diabetes.

Small published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H14IN, HPLC of Formula: 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Verma, Suryadev K. published the artcileManganese-Catalyzed C(sp²)-H Alkylation of Indolines and Arenes with Unactivated Alkyl Bromides, Recommanded Product: 1-Bromooctane, the publication is Chemistry – An Asian Journal (2022), 17(9), e202200103, database is CAplus and MEDLINE.

Selective C(sp²)-H bond alkylation of indoline like 2,3-dihydro-1-(2-pyridinyl)-1H-indole, carbazole like 9-(2-pyridinyl)-9H-carbazole and (2-pyridinyl)arenes I (R¹ = H, 4-Me, 4-OMe, 3-F₃C) with unactivated alkyl bromides R²(CH₂)₂Br (R² = Et, Pr, 4-(9H-carbazol-9-yl)butyl, etc.) is achieved using MnBr₂ catalyst in the absence of an external ligand. The alkylation uses a simple LiHMDS base and avoids the necessity of Grignard reagent, unlike other Mn-catalyzed C-H functionalization. This reaction proceeded either through a five- or less-favored six-membered metallacycle, and tolerated diverse functionalities, including alkenyl, alkynyl, silyl, aryl ether, pyrrolyl, indolyl, carbazolyl and alkyl bearing fatty alc. and polycyclic-steroid moieties. Alkylation follows a single electron transfer (SET) pathway involving 1e oxidative addition of alkyl bromide and rate-limiting C-H metalation.

Chemistry – An Asian Journal published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C4H6N2, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wall, Leo A. published the artcileReactions of polyfluorobenzenes with nucleophilic reagents, Safety of 4-Bromo-2,3,5,6-tetrafluorophenol, the publication is Journal of Research of the National Bureau of Standards, Section A: Physics and Chemistry (1963), 67A(5), 481-97, database is CAplus and MEDLINE.

A mixture of 26.5 g. C₆F₆, 26.5 g. 85% KOH, and 75 ml. H₂O was heated in a sealed bomb at 175° for 5 hrs. with agitation to give 33.1 g. C₆F₅OH, b. 144-5°. A mixture of 67 g. C₆F₅H, 21.6 g. KOH, 150 ml. pyridine, and 2 ml. H₂O was refluxed 1 hr., treated with 21.6 KOH, and refluxed 24 hrs. to give 21 g. 2,3,5,6-tetrafluorophenol, b₂₀ 47°. Similarly refluxing 36 g. C₆F₅Me and 28 g. KOH in 300 ml. tert-BuOH gave 12 g. 2,3,5,6-tetrafluoro-p-cresol, m. 52°. Reaction of 20 g. C₆F₅I with 2 g. KOH and 1 ml. H₂O in 100 ml. pyridine gave only one product, 2,3,5,6-tetrafluoro-4-iodophenol, m. 79-81°; benzoate m. 59-60.2°. Reaction of 66 g. C₆F₅Br with 28.5 g. KOH and 1 ml. H₂O in 150 ml. pyridine, however, gave a mixture of products: 3.5 g. 2-bromo-3,4,5,6-tetrafluorophenol, m. 41-3° (3,5-dinitrobenzoate, m. 104-5°); and 11.5 g. 4-bromo-2,3,5,6-tetrafluorophenol (3,5-dinitrobenzoate m. 131-3°). Similarly, 100 g. 2-chlorotetrafluoro-α,α,α-trifluorotoluene on treatment with 5.6 g. KOH and 1 ml. H₂O in 100 ml. pyridine gave 2.5 g. 2-chlorotrifluoro-α,α,α-trifluoro-o-cresol, b₁₅ 92-3°, n²⁴_D 1.4510; and 15 g. 2-chlorotrifluoro-α,α,α-trifluoro-p-cresol, b₁₅ 102-3°, n²⁴_D 1.4510. The reactions of polyfluorobenzenes were then studied with alkoxides. A solution of 123.5 g. C₆F₅Br in 70 ml. pyridine was treated with a solution of 11.5 g. Na in 150 ml. MeOH during 1.5 hrs. and the mixture refluxed 15 hrs. and acidified with 1 l. 10% HCl to give 66 g. 4-bromo-2,3,5,6-tetrafluoroanisole, b₅ 79-81°, n²⁵_D 1.4812. Similarly, a mixture of 10 g. C₆F₅I in 50 ml. pyridine and 0.8 g. Na in 15 ml. MeOH on refluxing for 3 hrs. gave 1.5 g. unchanged C₆F₅I and 5.5 g. 2,3,5,6-tetrafluoro-4-iodoanisole (I), b₂₀ 113-15°, n²²_D 1.5229. Refluxing 1 g. I with 1 g. activated Cu powder for 12 min. gave 0.2 g. octafluoro-4,4′-dimethoxybiphenyl, m. 90-1.2°. To a cold solution of 9 g. Na in 250 ml. PhCH₂OH was added 75 g. C₆F₆ and the mixture refluxed 24 hrs. to give 30 g. benzyl pentafluorophenyl ether (II), m. 44°. A better yield was obtained when a solution of 4.6 g. Na and 22 g. PhCH₂OH in 250 ml. tert-BuOH was refluxed with 40 g. C₆F₆ for 40 hrs. to give 33 g. II. A solution of 8 g. C₆F₆ in 30 ml. HCONMe₂ was treated with 5.28 g. PhOK and the mixture refluxed 0.5 hr. to give 1 g. 2,3,5,6-tetrafluoro-1,4-diphenoxybenzene, m. 147-9°, and 3.5 g. 2,3,4,5,6-pentafluorophenyl phenyl ether, (III), m. 29°. III was also obtained by heating a mixture of 11 g. C₆F₅OK, 15 g. PhBr, and 1 g. Cu at 210° in a sealed bomb. A solution of 6 g. C₆F₅OK and 12.8 g. C₆F₆ in 30 ml. HCONMe₂ was refluxed 14 hrs. to give 1.5 g. bis(perfluorophenyl) ether, m. 67-9°, and a second product, m. 145-8°, probably p-bis(pentafluorophenoxy)2,3,5,6-tetrafluorobenzene. Similarly, a solution of 0.6 g. Na in 50 ml. EtOH refluxed with 5.3 g. C₆F₅NMe₂ 2 hrs. gave 5.1 g. 4-ethoxy-2,3,5,6-tetrafluoro-N,N-dimethylaniline, b. 34°. Reactions with amines were next investigated. A mixture of 280 g. C₆F₆ and 400 ml. 28% aqueous NH₃ was rocked in a sealed bomb for 2 hrs. at 235° to give 236 g. C₆F₅NH₂, m. 34°, and 28 g. tetrafluorophenylenediamine (sublimed 75°/1 mm.) shown by its nuclear magnetic resonance spectrum to be essentially the meta isomer mixed with a small amount of the para isomer. Similarly, heating a mixture of 56 g. C₆F₆ and 110 ml. 30% aqueous MeNH₂ at 220° for 3 hrs. gave 59% C₆F₅NHMe, b. 170-2°, and 25% 2,3,5,6-tetrafluoro-N,N’-diphenylphenylenediamine, m. 94°. The reaction product obtained by heating 50 g. C₆F₆ and 110 ml. 25% aqueous Me₂NH at 235° for 1 hr. was distilled at 1 mm. pressure and five fractions were collected. The first fraction (65%), b₁ 88°, was C₆F₅NMe₂. Fraction 2, b₁ 88-126°, was shown by vapor phase chromatography to be C₆F₅NMe₂ with 3 other compounds Fraction 3, b₁ 126-134°, consisted of 3 isomers of bis(dimethylamino)tetrafluorobenzene with the meta-isomer predominating. Fraction 4, b₁ 134-40°, contained equal amounts of the meta and para isomers. Fraction 5, b₁ 140-8°, was pure para isomer. The meta and para isomers could be separated by vapor phase chromatography. Similarly, heating a mixture of 30 g. C₆F₅Br and 70 ml. 28% NH₄OH at 200° for 2 hrs. gave 22 g. p-bromotetrafluoroaniline, m. 61°. Heating 16 g. C₆F₅I and 30 ml. 8% NH₄OH at 165° for 2 hrs. gave 7.6 g. tetrafluoro-p-iodoaniline, m. 77°. Benzyl pentafluorophenyl ether (20 g.) was heated with large excess of 28% NH₄OH to give 3 g. p-(benzyloxy)tetrafluoroaniline, m. 97°. Similarly, heating 50 g. 2-chlorotetrafluoro-α,α,α-trifluorotoluene and 120 ml. 28% NH₄OH at 21° for 2 hrs. gave 22 g. 2-chlorotrifluoro-α,α,α-trifluoro-p-toluidine, which decomposed readily at room temperature in the presence of air. To 100 ml. anhydrous NH₃ at -70° were added 0.1 g. Fe(NO₃)₃ and 2.99 g. Na and, after disappearance of the blue color, 25 g. C₆F₅OMe during 45 min. After 5 hrs. at -70° the reaction mixture was worked up to give 7 g. unreacted C₆F₅OMe, 2.8 g. tetrafluoro-p-anisidine, m. 75-6.5°, 1.2 g. 4,4′-dimethoxyoctafluorodiphenylamine, m. 78-9°, and 2.2 g. 4,4′,4”-trimethoxydodecafluorotriphenylamine, b. 157-9°, n²³_D 1.5005. Diazotization of C₆F₅NH₂ required concentrated acids since the salts of the amine hydrolyzed very readily in dilute solutions In 48% HBr, diazotization of C₆F₅NH₂ gave C₆F₅N:NNHC₆F₅, probably owing to slow diazotization. The reaction was temperature-dependent, the diazoaminobenzene being formed much faster at 10° than at -10°. The product decomposed in warm HBr to give 5.4% C₆F₅Br and a mixture of o- and p-dibromotetrafluorobenzenes. In concentrated H₂SO₄ the reaction was very slow even at 25°. Addition of HOAc hastened it. Deamination with hypophosphorus acid gave a mixture probably of C₆F₅H and C₆H₂F₄. Better diazotization could be carried out in liquid HF and the diazo product underwent successful Sandmeyer reaction. A solution of 20 g. C₆F₅NH₂ in 75 ml. anhydrous HF at -20° was treated with 7.27 g. NaNO₂ during 30 min. After stirring for 1 hr. at -10° the mixture was treated with 17.6 g. KI during 30 min. and allowed to warm to 25° in 1 hr. to give 16.5 g. C₆F₅I, b₃₅ 77-9°. Use of 12 g. KBr and 15 g. Cu₂Br₂ instead of KI gave 35% C₆F₅Br. The reaction of diazotized amine with C₆F₅OLi gave C₆F₅N:N(O)C₆F₅, which decomposed on removal of solvent. The Sandmeyer nitrile synthesis was not successful. A solution of 10 g. C₆F₅NH₂ in 100 ml. HOAc was oxidized with 25 ml. 30% H₂O₂ at 25° for 24 hrs. to give decafluoroazoxybenzene (IV), m. 53-4°. A mixture of 5 g. IV, 15 g. Zn powder, 5 g. NH₄Cl, 10 ml. H₂O, and 75 ml. 95% EtOH refluxed 30 min. gave 2 g. decafluoroazobenzene, m. 57-9°. C₆F₆ reacted readily with organolithium compounds A solution of MeLi, prepared from 4.5 g. Li and 43 g. MeI in 50 ml. ether, was cooled to -10° to -20°, added dropwise to a solution of 60 g. C₆F₆ in 250 ml. pentane, and stirred for 17 hrs. at room temperature to give 34 g. C₆F₅Me, b. 115°. Similarly, reaction of BuLi, prepared from 1.86 g. Li and 18.3 g. BuBr in 30 ml. ether, with 25.3 g. C₆F₆ in 25 ml. ether gave 10.5 g. unreacted C₆F₆, 7 g. C₆F₅Bu, b₂₅ 86-7°, n²⁰_D 1.4229, and 2.5 g. of a compound, b₁ 230°, n²⁰_D 1.4683, probably impure tributyldifluorobenzene. Similarly, 32.7 g. C₆F₆ in 150 ml. ether with 0.18 mole PhLi in 250 ml. ether gave 8.5 g. 2,3,5,6-tetrafluoro-p-terphenyl, m. 220°, and 33 g. C₆F₅Ph, m. 69°. A similar reaction of 18.6 g. C₆F₆ and isopropenyllithium prepared from 12.1 g. 2-bromopropene gave 5 g. 2,3,4,5,6-pentafluoro-α-methylstyrene, b₅₂ 72-4°. With vinyllithium, prepared from 0.1 mole PhLi and 0.025 mole tetravinyltin, 18.6 g. C₆F₆ gave 4 g. unreacted C₆F₆ and 20% C₆F₅CH:CH₂, b₂₅ 34°. LiAlH₄ reduction of 21 g. C₆F₆ in ether gave 17 g. of a mixture of C₆F₆ and C₆F₅H which was separated by vapor phase chromatography to give 7.5 g. C₆HF₅. All the products in all above reactions were studied by infrared and nuclear magnetic resonance spectroscopy. The mechanism of reaction and the directional effects were discussed.

Journal of Research of the National Bureau of Standards, Section A: Physics and Chemistry published new progress about 1998-61-4. 1998-61-4 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzene,Phenol, name is 4-Bromo-2,3,5,6-tetrafluorophenol, and the molecular formula is C17H14O5, Safety of 4-Bromo-2,3,5,6-tetrafluorophenol.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hmamouchi, Mohammed published the artcileSynthesis and polymerization of racemic and optically active substituted β-propiolactones. V. α-Methyl-β-propiolactone, Application In Synthesis of 56970-78-6, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1988), 26(6), 1593-607, database is CAplus.

R(+) And S(-) enantiomers of α-methyl-β-propiolactone (I) were synthesized from the corresponding α-Me β-hydroxymethylpropionates and racemic I from Me methacrylate. The corresponding racemic and optically active polylactones (II) were prepared by anionic polymerization, in bulk and in solution, as well as II of intermediate optical purities. Racemic II was amorphous whereas optically active II was semicrystalline for optical purities >51%. Melting temperatures and enthalpies of fusion of the semicrystalline II varied with optical purity whereas glass transition temperatures remained invariant for all polymers, at about -28°.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Application In Synthesis of 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Da Settimo, Federico published the artcile[1,2,4]Triazino[4,3-a]benzimidazole Acetic Acid Derivatives: A New Class of Selective Aldose Reductase Inhibitors, SDS of cas: 76283-09-5, the publication is Journal of Medicinal Chemistry (2001), 44(25), 4359-4369, database is CAplus and MEDLINE.

Acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole (TBI) were synthesized and tested in vitro and in vivo as a novel class of aldose reductase (ALR2) inhibitors. (10-Benzyl[1,2,4]triazino[4,3-a]benzimidazole-3,4(10H)-dion-2-yl)acetic acid (I), displayed the highest inhibitory activity (IC₅₀ = 0.36 μM) and effective in preventing cataract development in severely galactosemic rats when administered as an eyedrop solution All the compounds investigated were selective for ALR2, since none of them inhibited appreciably aldehyde reductase, sorbitol dehydrogenase, or glutathione reductase. The activity of I was lowered by inserting various substituents on the pendant Ph ring, by shifting the acetic acid moiety from the 2 to the 3 position of the TBI nucleus, or by cleaving the TBI system to yield benzimidazolylidenehydrazines as open-chain analogs. A three-dimensional model of human ALR2 was built, taking into account the conformational changes induced by the binding of inhibitors such as zopolrestat, to simulate the docking of I into the enzyme active site. The theor. binding mode of I was fully consistent with the structure-activity relationships in the TBI series and will guide the design of novel ALR2 inhibitors.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, SDS of cas: 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Earle, Martyn J. published the artcileSynthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Bioorganic & Medicinal Chemistry Letters (1997), 7(17), 2187-2192, database is CAplus.

A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by >75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Crosignani, Stefano published the artcileDiscovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases, Name: 4-((3-Bromo-4-methylphenyl)sulfonyl)morpholine, the publication is Journal of Medicinal Chemistry (2011), 54(20), 7299-7317, database is CAplus and MEDLINE.

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound, I, by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with K_i < 10 nM) but also excellent potencies in a human whole blood assay (IC₅₀ < 100 nM; PGD2-induced eosinophil shape change). Addnl. optimization of the pharmacokinetic characteristics led to the identification of several compounds suitable for in vivo testing. Of these, II (R¹ = n-Pr, R² = Me; R¹ = n-Pr, R² = F) were tested in two different pharmacol. models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg).

Journal of Medicinal Chemistry published new progress about 850429-74-2. 850429-74-2 belongs to bromides-buliding-blocks, auxiliary class Morpholine,Bromide,Sulfamide,Benzene, name is 4-((3-Bromo-4-methylphenyl)sulfonyl)morpholine, and the molecular formula is C11H14BrNO3S, Name: 4-((3-Bromo-4-methylphenyl)sulfonyl)morpholine.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Melancon, Bruce J. published the artcileIsatin replacements applied to the highly selective, muscarinic M₁ PAM ML137: Continued optimization of an MLPCN probe molecule, Product Details of C7H5Br2F, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(2), 412-416, database is CAplus and MEDLINE.

This Letter describes the continued optimization of an MLPCN probe mol. I (ML137) with a focused effort on the replacement/modification of the isatin moiety present in this highly selective M₁ PAM. A diverse range of structures were validated as viable replacements for the isatin, many of which engendered sizeable improvements in their ability to enhance the potency and efficacy of acetylcholine when compared to ML137. Muscarinic receptor subtype selectivity for the M₁ receptor was also maintained.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary