Month: December 2022

Kelkar, Ashutosh A. published the artcileCopper-catalyzed amination of aryl halides: single-step synthesis of triarylamines, Formula: C30H24BrCuN2P, the publication is Tetrahedron Letters (2002), 43(40), 7143-7146, database is CAplus.

A simple and efficient methodol. for the synthesis of triarylamines in a single step has been demonstrated using a ligand-free CuI catalyst and potassium tert.-butoxide as the base. Use of chelating ligands leads to the formation of triarylamine derivatives selectively (95% yield) with high catalytic activity.

Tetrahedron Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Formula: C30H24BrCuN2P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhu, Shaojuan published the artcileIn vitro and in vivo evaluation of antioxidant activity of ARIs: benzothiadiazine and pyridothiadiazine derivatives, Application of 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Journal of Chemical and Pharmaceutical Research (2014), 6(5), 173-179, 7 pp., database is CAplus.

Increased oxidant stress plays an important role in the chronic complications of diabetes. This study aimed to examine if our previously synthesized aldose reductase inhibitors (ARIs), benzothiadiazine 1,1-dioxide derivatives and the structural analogs pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide derivatives, have the potent as antioxidants. Several assays have been used to estimate antioxidant capacities including DPPH, MDA and sorbitol assays. Effect of concentration, PH and sunlight on DPPH scavenging activity were determined, and results showed benzothiadiazine 1,1-dioxide derivatives (compound 7a, 7b, 7c) at both concentration of 10-5 M and 10-4 M had notable scavenging activity against DPPH, significantly higher than that of pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide derivatives(compound 7’a, 7’b, 7’c). The PH demonstrated no effect on the activity and sunlight was essential for the activity. The brain MDA levels (MDA, an index of lipid peroxidation) for compounds 7a, 7b, 7c significantly decreased comparing with the neg. control, the brain homogenate sample induced by oxidant system Fe(III) ascorbic acid. Oral administration of compound 7’a, 7’b and 7’c to groups of STZ-induced rats for 5 days decreased the level of sciatic nerve sorbitol, The inhibition of sorbitol level in the range of 24%-35% for 7’a, 7’b and 7’c, showing some difference with the in vitro study.

Journal of Chemical and Pharmaceutical Research published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C18H20N2O12, Application of 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Forero-Doria, Oscar published the artcileNovel N-benzoylimidazolium ionic liquids derived from benzoic and hydroxybenzoic acids as therapeutic alternative against Biofilm-forming bacteria in skin and soft-tissue infections, Computed Properties of 111-83-1, the publication is Bioorganic Chemistry (2022), 105914, database is CAplus and MEDLINE.

The skin and soft tissue infections (SSTIs) -producing pathogens have acquired resistance to a wide range of antimicrobials, thus it is highly relevant to have new treatment alternatives. In this study, we report the synthesis, characterization, and antibacterial activity of three novel series of ionic liquids (ILs) derived from benzoic and hydroxybenzoic acids, with different lengths of the alkyl chain. The min. inhibitory concentration (MIC) were tested in Gram-pos.: Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes, and Gram-neg.: Acinetobacter baumannii and Escherichia coli, showing a MIC range of 0.01562-2.0 mM, with the activity varying according to the aromatic ring functionalization and the length of the alkyl chains. Regarding the antibiofilm activity, different efficacy was observed among the different ILs, some of them presenting antibiofilm activities close to 80% as in the case of those derived from syringic acid with an alkyl chain of six carbon atoms against Pseudomonas aeruginosa. Furthermore, the cell viability in HaCaT cells was determined, showing a half maximal effective concentration (EC₅₀) values higher than the MIC values. The antimicrobial and antibiofilm results, along with not producing cellular toxicity at the MIC values shows that these ILs could be a promising alternative against SSTIs.

Bioorganic Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Computed Properties of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Prinz, Michaela published the artcile1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier, Product Details of C7H5Br2F, the publication is European Journal of Pharmaceutical Sciences (2013), 49(4), 603-613, database is CAplus and MEDLINE.

Given the fundamentally multifactorial character of Alzheimer’s disease (AD), addressing more than one target for disease modification or therapy is expected to be highly advantageous. Here, following the cholinergic hypothesis, we aimed to inhibit both acetyl- and butyrylcholinesterase (AChE and BuChE) in order to increase the concentration of acetylcholine in the synaptic cleft. In addition, the formation of the amyloid β fibrils should be inhibited and already preformed fibrils should be destroyed. Based on a recently identified AChE inhibitor with a 1,4-substituted 4-(1H)-pyridylene-hydrazone skeleton, a substance library has been generated and tested for inhibition of AChE, BuChE, and fibril formation. Blood-brain barrier mobility was ensured by a transwell assay. Whereas the p-nitrosubstituted compound 18C shows an anti-AChE activity in the nanomolar range of concentration (IC₅₀ = 90 nM), the bisnaphthyl substituted compound 20L was found to be the best overall inhibitor of AChE/BuChE and enhances the fibril destruction.

European Journal of Pharmaceutical Sciences published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kim, Ji-Hoon published the artcileHigh open-circuit voltage organic photovoltaic cells fabricated using semiconducting copolymers consisting of bithiophene and fluorinated quinoxaline or triazole derivatives, Quality Control of 303734-52-3, the publication is Synthetic Metals (2014), 88-96, database is CAplus.

Two new alternating copolymers consisting of bithiophene and fluorinated quinoxaline or fluorinated benzotriazole derivatives, namely, poly[{4,4′-bis(2-ethylhexyl)-2,2′-bithiophene-5,5′-diyl}-alt-{6,7-difluoro-5,5-(5,8-di-2-thienyl-2,3-bis(4-octyloxyl)phenyl) quinoxaline}] (PBT-DFDTQX) and poly[{4,4′-bis(2-ethylhexyl)-2,2′-bithiophene-5,5′-diyl}-alt-{4,7-bis(5-thiophen-2-yl)-5,6-difluoro-2-(heptadecan-9-yl)-2H-benzo[d][1,2,3]triazole}] (PBT-DFDTBTz), were synthesized by the Stille cross coupling reaction for application in organic photovoltaic cells. The optical band gaps of PBT-DFDTQX and PBT-DFDTBTz are 1.77 and 1.90 eV, resp. The synthesized polymers showed relatively deep HOMO energy levels (-5.52 eV for PBT-DFDTQX and -5.54 eV for PBT-DFDTBTz) owing to the strong electron accepting nature of F. The polymers were used to fabricate bulk heterojunction photovoltaic devices with [6,6]-Ph C₇₁-butylic acid Me ester (PC₇₁BM) as the electron acceptor. Devices fabricated using PBT-DFDTQX and PBT-DFDTBTz showed the maximum power conversion efficiency (PCE) of 4.01 and 4.22%, resp., with a high open-circuit voltage of over 0.95 V under AM 1.5 G (100 mW/cm²) conditions.

Synthetic Metals published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Quality Control of 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chun, Yong-Jin published the artcileSynthesis of ω-phthalimidoalkylphosphonates, Application of Diethyl (bromomethyl)phosphonate, the publication is Synthesis (1994), 909-10, database is CAplus.

Di-Et phthalimidoalkylphosphonates I (n = 1,2,3,4) were synthesized by the reaction of di-Et bromoalkylphosphonates with N-(tert-butyldimethylsilyl)phthalimide in the presence of tetrabutylammonium fluoride.

Synthesis published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Application of Diethyl (bromomethyl)phosphonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Marenets, M. S. published the artcile4-Trifluoromethylthiostyrene, HPLC of Formula: 21101-63-3, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1968), 34(9), 938-40, database is CAplus.

Addition of Br to refluxing p-F3CSC6H4Me illuminated with a 300-w. lamp formed p-F3CSC6H4CH2Br (I), m. 52-2.5° (aqueous MeOH). I and hexa-methylenetetramine in 50% HOAc refluxed 2 hrs., then refluxed 15 min. with aqueous HCl formed p-F3CSC6H4CHO (II), m. 26-7°, also prepared from p-F3CC6H4CONHPh via reaction with PCl5 in PhMe and reduction in an Et2O solution of SnCl2 saturated with HCl. II and MeMgI formed p-F3CSC6H4CHMeOH (III), b18 124°, d20 1.2854, n20D 1.4938. p-F3CSC6H4CH:CHCO2H (IV), m. 199-200°, was prepared from II and CH2(CO2H)2 in pyridine containing a little piperidine. p-F3CSC6H4CH:CH2, b18 93° [dibromide m. 34-5° (EtOH)], was obtained from III and IV by dehydration and decarboxylation, resp.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, HPLC of Formula: 21101-63-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Zhen-Zhen published the artcileNickel-Catalyzed Reductive C(sp²)-Si Coupling of Chlorohydrosilanes via Si-Cl Cleavage, Application In Synthesis of 111-83-1, the publication is Angewandte Chemie, International Edition (2022), 61(21), e202200215, database is CAplus and MEDLINE.

Authors report here a new method for the synthesis of organohydrosilanes from phenols and ketones. This method is established through reductive C-Si coupling of chlorohydrosilanes via unconventional Si-Cl cleavage. The reaction offers access to aryl- and alkenylhydrosilanes with a scope that is complementary to those of the established methods. Electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles, as well as cyclic and acyclic alkenyl electrophiles, were coupled successfully. Functionalities, including Grignard-sensitive groups (e.g., primary amine, amide, phenol, ketone, ester, and free indole), acid-sensitive groups (e.g., ketal and THP protection), alkyl-Cl, pyridine, furan, thiophene, Ar-Bpin, and Ar-SiMe₃, were tolerated. Gram-scale(coating) reaction, incorporation of -Si(H)R₂ into complex biol. active mols., and derivatization of formed organohydrosilanes are demonstrated.

Angewandte Chemie, International Edition published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C5H13Cl2N, Application In Synthesis of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Brem, Jurgen published the artcileImitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors, Related Products of bromides-buliding-blocks, the publication is Nature Chemistry (2022), 14(1), 15-24, database is CAplus and MEDLINE.

Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases (MBLs). Here we report the discovery and optimization of potent broad-spectrum MBL inhibitors. A high-throughput screen for NDM-1 inhibitors identified indole-2-carboxylates (InCs) as potential β-lactamase stable β-lactam mimics. Subsequent structure-activity relationship studies revealed InCs as a new class of potent MBL inhibitor, active against all MBL classes of major clin. relevance. Crystallog. studies revealed a binding mode of the InCs to MBLs that, in some regards, mimics that predicted for intact carbapenems, including with respect to maintenance of the Zn(II)-bound hydroxyl, and in other regards mimics binding observed in MBL-carbapenem product complexes. InCs restore carbapenem activity against multiple drug-resistant Gram-neg. bacteria and have a low frequency of resistance. InCs also have a good in vivo safety profile, and when combined with meropenem show a strong in vivo efficacy in peritonitis and thigh mouse infection models. [graphic not available: see fulltext]

Nature Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Khorsand Kheirabad, Atefeh published the artcileColloidal dispersion of poly(ionic liquid)/Cu composite particles for protective surface coating against SAR-CoV-2, Name: 1-Bromododecane, the publication is Nano Select (2022), 3(1), 227-232, database is CAplus and MEDLINE.

Herein, we report a waterproof anti-SARS-CoV-2 protective film prepared by spray-coating of an aqueous colloidal dispersion of poly(ionic liquid)/copper (PIL/Cu) composite nanoparticles onto a substrate. The PIL dispersion was prepared by suspension polymerization of 3-dodecyl-1-vinylimdiazolium bromide in water at 70°C. The copper acetate salt was added into the PIL nanoparticle dispersion and in situ reduced into copper nanoparticles anchoring onto the PIL nanoparticles. Despite being waterborne, the PIL in bulk is intrinsically insoluble in water and the formed coating is stable in water. The formed surface coating by PIL/copper composite nanoparticles was able to deactivate SARS-CoV-2 virions by 90.0% in 30 min and thus may effectively prevent the spread of SARS-CoV-2 through surface contact. This method may provide waterborne dispersions for a broad range of antivirus protective surface coatings for both outdoor and indoor applications.

Nano Select published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Name: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary