Month: December 2022

Liu, Yu-Cheng published the artcileFree radical reaction. Reaction of Grignard reagents with 2-bromo-2,3-dimethylbutane and with 1-chloro-1-methylcyclohexane in the presence of cobaltous halides, Application In Synthesis of 594-81-0, the publication is Acta Chim. Sinica (1956), 104-11, database is CAplus.

cf. C.A. 51, 14569e. CHMe₂CBrMe₂ (I) decomp, when treated with PhMgBr (II) and CoBr₂ (III) to give 35% CHMe₂CHMe₂ (IV), 31% CHMe₂CMe:CH₂ (V), and 2% CMe₂:CMe₂ (VI). I (0.45 mole) added dropwise to 0.5 mole freshly prepared II in 250 ml. Et₂O containing III with stirring, stirred with cooling several hrs., the product poured into ice H₂O, 30 ml. AcOH added, the Et₂O layer separated, washed neutral, dried, and fractionally distilled to 80° gave 25.8 g. fraction, b. 53-8°, n²⁰_D 1.3822, containing some V (infrared spectrum), mainly IV as shown by oxidation with O₃ in CCl₄ at 0° to CH₂O (IV derivative with saturated 5,5-dimethyldihydroresorcinol, m. 192-3°) and some Me₂CHCOMe; 2,4-(O₂N)₂C₆H₃NHNH₂ derivative, m. 114-15°. The fraction b. 71.5° (0.7 g.) proved to be VI, m. 165° (sublimation). The residue gave 33 g. biphenyl, m. 70-2°, on steam-distillation Treatment of 9.7 g. I with 11.2 g. KOH in 50 ml. glycol at 100-10° 1.5 hrs. gave 4.1 g. distillate, n²⁰_D 1.4076, a mixture of 79% VI and 21% V. Bromination of 0.5 g. of this mixture in CCl₄ yielded 61% CBrMe₂CBrMe₂, m. 170-5°. 1-Methylcyclohexyl chloride (VII) (0.2 mole) in 100 ml. absolute Et₂O added dropwise to 0.3 moles MeMgBr (VIII) in 320 ml. Et₂O with frequent addition (6.5 g. total) of III and stirring continued an addnl. hr. after complete evolution of the gas gave as the main distillate, b. 100-3°, n²⁰_D 1.4371, 62% mixture of C₆H₁₁Me, 1-methylcyclohexene (IX), and methylenecyclohexane. The % unsaturation of bromate-bromide titration and catalytic hydrogenation with Pt was 51, infrared absorption spectrum showed the presence of C:CH, and group oxidation with O₃ gave cyclohexanone; 2,4-dinitrophenylhydrazone, m. 158.5-9.5°. VII (26.5 g.) in 40 ml. absolute Et₂O with 0.4 mole iso-PrMgBr in 200 ml. Et₂O in the presence of 2.6 g. III in the same way as above gave 11.3 g. distillate, b. 100-3°, n²⁰_D 1.4348, % unsaturation = 42, a mixture of the same products as from VII and VIII. VII (5 g.) and 25 ml. 4N NaOH refluxed on a steam-bath 3 hrs., extracted with Et₂O, and distilled, gave 2.4 g. IX, b. 107-8°, n²⁰_D 1.4364. It is therefore suggested the disproportionation of alkyl radicals in solution is probably a bimol. reaction and the number of α-H atoms has a directive influence upon the orientation of olefin formation.

Acta Chim. Sinica published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Application In Synthesis of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Chang-chun published the artcileSelective bromination of p-hydroxybenzaldehyde, COA of Formula: C10H16Br3N, the publication is Huaxue Shijie (2008), 49(8), 481-483, database is CAplus.

The selective bromination of 4-hydroxybenzaldehyde (HBD) with benzyltrimethylammonium tribromide in dichloromethane-methanol was studied. A method for the synthesis of 3-bromo-4-hydroxybenzaldehyde is reported here. The effects of reaction conditions were determined When the mol ratio of 4-hydroxybenzaldehyde to benzyltrimethylammonium tribromide was 1.0:1.05, volume ratio of dichloromethane to methanol was 5:1, reaction temperature was 30° and reaction time was 1 h, the yield of monobromide reached 92.5% and the selectivity of monobromide reached 99%.

Huaxue Shijie published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, COA of Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lerman, L. S. published the artcileSymposium on molecular action of mutagenic and carcinogenic agents. Acridine mutagens and DNA structure, Recommanded Product: Dimidium bromide, the publication is Journal of Cellular and Comparative Physiology (1964), 64(2;Pt. II;Suppl. 1), 1-13, discussion 13-18, database is CAplus.

Evidence for intercalation of acridine compounds between 2 otherwise sequential base pairs was obtained by studies of sedimentation, low angle x-ray scattering, flow dichroism, flow-polarized fluorescence, and chem. reactivity. Such binding requires a local untwisting and extension of the double helix. The intercalated mols. have a decreased chem. reactivity. They increase the stability of the double helix as shown by an increase in the thermal transition temperature Intercalation into complexes formed between polyadenylic and polyuridylic acids makes the double helix more stable than the triple. Intercalation seems to be a prerequisite for mutagenicity of the insertion-deletion type but the acridine structure is not essential and not all intercalating mols. are mutagenic.

Journal of Cellular and Comparative Physiology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Larsson, Erik published the artcileSome S-containing β-substituted derivatives of isobutyric acid, Name: 3-Bromo-2-methylpropanoic acid, the publication is Chalmers Tekniska Hoegskolas Handlingar (1944), 3-17, database is CAplus.

The preparation is described of β-alkyl, β-aryl, and β-arylalkyl sulfide derivatives, RSCH₂CHMeCO₂H (I), and of the corresponding sulfone carboxylic acids, RSO₂CH₂CHMeCO₂H (II). The synthesis of BrCH₂CHMeCO₂H (III) was improved by interacting HBr with CH₂: CMeCO₂H (IV) in CHCl₃. HSCH₂CHMeCO₂H (V) was prepared from (1) IV via MeCOSCH₂CHMeCO₂H, (2) III and NaHS, or (3) fission of EtOCS₂CH₂CHMeCO₂H prepared from EtOCS₂K and III. The Me derivative of V was prepared in aqueous solution by reaction of the di-Na salt of V with Me₂SO₄ or KMeSO₄; the Et, Pr, PhCH₂, and PhCH₂CH₂ derivatives from their halides and the di-Na salt of V in aqueous alc. solution The Ph derivative was prepared in aqueous solution from PhSNa and the Na salt of III. All of the sulfide acids (I) prepared consumed 4 equivalents of Br per mol. on oxidation in HCl solution, indicating conversion to the sulfone carboxylic acids (II). The latter were prepared by Br or KMnO₄ oxidation. The following phys. properties are given for I (R given): b.p./mm., d₄²⁰, n_D²⁰, n_F²⁰-n_C²⁰, MR_D(found) and mol. volume at 20°: Me 129-30°/12, 1.1086, 1.4815, 0.0112, 34.48, 121.1; Et 140-1°/12, 1.0684, 1.4780, 0.0110, 39.27, 138.7; Pr 138-9°/6, 1.0405, 1.4761, 0.0107, 43.97, 155.9; and PhCH₂CH₂ 190-5°/6, 1.1207, 1.5450, 0.0159, 63.28, 200.1. The I where R is iso-Pr b₈ 135-7°, m. 31°; Ph m. 45°; PhCH₂ m. 43°. The m.ps. of the following II are: Me 134°, Et 82°, Pr 75-6°, iso-Pr 109°, Ph 113°, PhCH₂ 154°, and PhCH₂CH₂ 93°. The PhCH₂ derivative of V was oxidized by K₂S₂O₈ or H₂O₂ to the sulfoxide (m. 110-11°) but the 2 theoretically possible forms of PhCH₂SOCH₂CHMeCO₂H could not be isolated. Oxidation of V with Br gave the sulfone acid. Compounds like II apparently ionize thus in alk. solution: RSO₂CH₂CHMeCO₂^– + OH^– = RSO₂^– + CH₂:CMe-CO₂^– + H₂O.

Chalmers Tekniska Hoegskolas Handlingar published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Name: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kuivila, Henry G. published the artcileOrganotin hydrides and organic free radicals, SDS of cas: 594-81-0, the publication is Accounts of Chemical Research (1968), 1(10), 299-305, database is CAplus.

The preparation and properties of organotin hydrides, their reduction of alkyl and aryl halides, aldehydes, ketones, isocyanates, and isothiocyanates and their addition to C-C double or triple bonds, their use in the study of organic free radicals, i.e. octen-5-yl free radicals, cyclization of unsaturated acyclic radicals, the tritylmethyl radical, free-radical β-eliminations, vinyl free radicals and photoreduction, are reviewed with 39 references.

Accounts of Chemical Research published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, SDS of cas: 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Henderson, J. Frank published the artcileInhibition of purine metabolism in Ehrlich ascites carcinoma cells by phenanthridinium compounds related to ethidium bromide, Name: Dimidium bromide, the publication is Cancer Research (1963), 491-5, database is CAplus and MEDLINE.

The effect of 10 phenanthridinium derivatives on the incorporation of adenine and glycine into the nucleic acids and proteins of Ehrlich ascites carcinoma cells in vitro, has been studied. Only 1 compound markedly inhibited incorporation of glycine into nucleic acids and proteins, whereas all the drugs inhibited incorporation of adenine into nucleic acids.

Cancer Research published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Name: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grzadka, E. published the artcileCompetitive adsorption in the system: carboxymethylcellulose/surfactant/electrolyte/Al₂O₃, Recommanded Product: Dimidium bromide, the publication is Cellulose (Dordrecht, Netherlands) (2011), 18(2), 291-308, database is CAplus.

The adsorption of CM-cellulose (CMC) in the presence or absence of the surfactants: anionic SDS, nonionic Triton X-100 and their mixture SDS/TX-100 from the electrolyte solutions (NaCl, CaCl₂) on the alumina surface (Al₂O₃) was studied. In each measured system the increase of CMC adsorption in the presence of surfactants was observed This increase was the smallest in the presence of SDS, a bit larger in the presence of Triton X-100 and the largest when the mixture of SDS/Triton X-100 was used. These results are a consequence of formation of complexes between the CMC and the surfactant particles. Moreover, the dependence between the amount of surfactants’ adsorption and the CMC initial concentration was measured. It comes out that the surfactants’ adsorption amount is not dependent on the CMC initial concentration and moreover, it is unchanged in the whole measured concentration range. The influence of kind of electrolyte, its ionic strength as well as pH of a solution on the amount of the CMC adsorption at alumina surface was also measured. The amount of CMC adsorption is larger in the presence of NaCl than in the presence of CaCl₂ as the background electrolyte. It is a result of the complexation reaction between Ca²⁺ ions and the functional groups of CMC belonging to the same macromol. As far as the electrolyte ionic strength is concerned the increase of CMC adsorption amount accompanying the increase of electrolyte ionic strength is observed The reason for that is the ability of electrolyte cations to screen every electrostatic repulsion in the adsorption system. Another observation is that the increase of pH caused the decrease of CMC adsorption. The explanation of this phenomenon is connected with the influence of pH on both dissociation degree of polyelectrolyte and kind and concentration of surface active groups of the adsorbent.

Cellulose (Dordrecht, Netherlands) published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Griffin, C. E. published the artcilePhosphoryl stretching frequency correlation for phosphonic acid derivatives, Quality Control of 66197-72-6, the publication is Chemistry & Industry (London, United Kingdom) (1960), 1058-9, database is CAplus.

A plot of Σ σ* (Taft substituent constants) vs. γ_PO (as films in CS₂ or CCl₄) for 19 phosphonates [RP(O)XY] (I) gave a linear relationship; a least squares treatment of the data gave γ_PO = 16.80 Σσ* + 1198. The following I were studied (X = Y = OEt) (R given): Me, Et, Pr, Bu, n-C₆H₁₃, CH₂:CH, CH₂:CHCH₂, PhCH₂, Ph, ClCH₂, Cl₂CH, CCl₃ (II), BrCH₂, HOCH₂, AcCH₂. Also I (R, X, and Y given): Me, OMe, OMe; Me, OEt, NMe₂; Me, NMe₂, NMe₂ (III); Ph, H, OEt. The average deviation between calculated and observed frequencies was ±4 cm.^-1; the only significant deviation occurred with II and III, and may have arisen through disturbance of the normal inductive effects of the substituents by field effects. Major deviations from the linear relationship also occurred with frequency values obtained in the presence of H-bonding solvents. The following σ* values were tentatively assigned: (CH₂)₂CO₂Et, 0.39; (CH₂)₃CO₂Et, 0.39; NEt₂, 0.68.

Chemistry & Industry (London, United Kingdom) published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Quality Control of 66197-72-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gill, B. S. published the artcileSurra. XI. Chemotherapeutic susceptibility of Trypanosoma evansi, Synthetic Route of 518-67-2, the publication is Indian Journal of Animal Sciences (1973), 43(4), 226-9, database is CAplus.

The median effective and curative doses of 39 trypanocidal agents are reported for T. evansi infections in rats. These two parameters indicated the comparative chemotherapeutic susceptibility of the organism, which is the causative agent for surra disease in domestic animals. Arsenicals, antimonials, acriflavine, diamidines, sulfonated naphthylamine derivatives, aminoquinaldine derivatives, phenanthridines, nitrofurazone, and terephthalanilide compounds were tested.

Indian Journal of Animal Sciences published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gajda, Tadeusz published the artcilePreparation of diethyl 1-bromoalkylphosphonates, HPLC of Formula: 66197-72-6, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1990), 53(1-4), 327-31, database is CAplus.

RCHBrP(O)(OEt)₂ (R = H, Me, Et, Pr, Ph) were prepared by treating RCH(OH)P(O)(OEt)₂ with Ph₃P and CBr₄ in refluxing C₆H₆, or with Ph₃PBr₂ and pyridine in MeCN at room temperature Yields of 22-67% were obtained.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, HPLC of Formula: 66197-72-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary