Month: December 2022

Sun, Xin published the artcileMetal-Free Hypervalent-Iodine-Promoted C3 Difluorination and C2 Oxidation of N-Substituted Indoles, Category: bromides-buliding-blocks, the publication is Asian Journal of Organic Chemistry (2017), 6(6), 690-693, database is CAplus.

A metal-free, highly regioselective C3 difluorination and C2 oxidation of N-substituted indoles I (R¹ = 5-Br, 7-Cl, 3,6-F₂, etc.; R² = Bn, 4-ClC₆H₄CH₂, 2,3,5-F₃C₆H₂CH₂, etc.) with the aid of in situ generated PhIF₂ in the presence of two types of fluorinating agents such as Pyr·HF and Et₃N·HF was reported. This reaction provided 3,3-difluoro-2-oxindoles II with yields up to 64% under mild reaction conditions. A mechanism for this reaction was proposed.

Asian Journal of Organic Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H10BNO4S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hou, Jin published the artcileEvaluation of Novel N-(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells, Formula: C7H5Br2F, the publication is Chemical Biology & Drug Design (2015), 86(2), 223-231, database is CAplus and MEDLINE.

In this study, a series of novel N-(piperidine-4-yl)benzamide derivatives was designed, synthesized, and evaluated for antitumor activity. Some compounds were found to have potent antitumor activity. In particular, compound 47 (N-(1-(2,6-difluorobenzyl)piperidine-4-yl)-4phenoxybenzamide) showed the most potent biol. activity against HepG2 cells, with an IC₅₀ value of 0.25 μM. Western blot anal. demonstrated that compound 47 inhibited the expression of cyclin B1 and p-Rb and enhanced the expression of p21, p53, Rb, and phospho-adenosine monophosphate-activated protein kinase (p-AMPK). Further, cell cycle arrest was observed by flow cytometry (FCM). In summary, compound 47 was screened to have potential activity for the treatment of hepatocarcinoma via the induction of cell cycle arrest by a p53/p21-dependent pathway.

Chemical Biology & Drug Design published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Nan published the artcileAlkylated lignin with graft copolymerization for enhancing toughness of PLA, Application of 1-Bromododecane, the publication is Journal of Materials Science (2022), 57(19), 8687-8700, database is CAplus.

A green modification method for effectively enhancing toughness of PLA was established. Herein, alk. lignin (LG) was firstly alkylated with dodecane, and then grafted with lactide (LA). The alkylated lignin-lactide graft copolymer (GLG-g-LA) was obtained via ring-opening polymerization (ROP). GLG-g-LA copolymer can be utilized as a functional filler to toughen polylactic acid (PLA) packaging film. The 31P-NMR of alkylated lignin (GLG) demonstrated that the peak of phenolic hydroxyl groups disappeared completely, while the relative peak intensity of carboxyl hydroxyl groups decreased significantly. The grafting rate of GLG-g-LA copolymer was improved more than twice times compared with lignin-lactide graft copolymer (LG-g-LA). Then LG-g-LA and GLG-g-LA copolymer were mixed with PLA to prepare different PLA composite films via casting method, resp. Particularly, the elongation at break of PLA/GLG-g-LA2 composite film increased to 41.98%, which was more than 20 times higher than PLA. In general, PLA/GLG-g-LA composite film with toughness, excellent UV barrier, water resistance and controllable gas permeation could be used as high-performance and biodegradable materials in packaging field.

Journal of Materials Science published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C5H5ClO2, Application of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shao, Jiahui published the artcileHumic acid rejection and flux decline with negatively charged membranes of different spacer arm lengths and charge groups, Formula: C3H6BrNaO3S, the publication is Journal of Membrane Science (2013), 38-45, database is CAplus.

A series of novel charged ultrafiltration membranes that differed in spacer arm length and charge group were generated by covalent attachment of neg. charged group to a com. available regenerated cellulose membrane. Rejection of humic acid and flux decline were compared with essentially neutral and neg. charged versions of regenerated cellulose membranes of different spacer arm lengths and charge groups. Effects of membrane mol. weight cut-off and solution pH on humic acid removal and flux decline on neutral and neg. charged membranes of different spacer arm lengths were also compared. The membrane with larger spacer arm length has better rejection of humic acid and less membrane fouling compared to that with smaller spacer arm length. The modified neg. charged membrane with a strongly acidic (sulfonic acid) functional group has better rejection of humic acid and less membrane fouling than that with a weakly acidic (carboxylic acid) functional group. These exptl. results are consistent with the larger charge of the membranes having larger spacer arm length and sulfonic acid group. This study confirms that the appropriate design of membrane charge functionality could be an effective way for better removal of humic acid and reduction of membrane fouling due to the electrostatic interactions with the combination effect of membrane pore size.

Journal of Membrane Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C8H8O3, Formula: C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Weng, Wei published the artcileSynthesis and electrochemical property of sulfone-functionalized imidazolium ionic liquid electrolytes, Safety of 2-Bromoethyl Methyl Sulfone, the publication is Electrochimica Acta (2013), 392-396, database is CAplus.

Sulfone-functionalized imidazolium ionic liquids were synthesized from direct nucleophilic substitution for the 1st time. Detailed NMR anal. of the products revealed the competition pathways of classic S_N2 substitution and E2 elimination in the synthesis reaction. Impurities from E2 elimination can easily be overlooked during the conventional method of ionic liquid preparation via S_N2 substitution. Initial electrochem. examination of the synthesized ionic liquids shows good compatibility with Li_1.1(Ni_1/3Co_1/3Mn_1/3)_0.9O₂ cathode material.

Electrochimica Acta published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C6H20Cl2N4, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mu, Bin published the artcilePositional Isomerism-Mediated Copolymerization Realizing the Continuous Luminescence Color-Tuning of Liquid-Crystalline Polymers, Synthetic Route of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(13), 5332-5341, database is CAplus.

Liquid crystals with color-tunable light emission are important for a variety of applications; however, achieving multicolor light-emitting liquid crystals whose emission colors can be fine-tuned remains challenging because the limited derivatization of mesogenic fluorophores disfavors the diversity of the emission. Here, we present a positional isomerism-mediated copolymerization strategy to obtain liquid-crystalline polymers with continuous luminescence color-tuning ability. The introduced α-/β-cyanostilbene positional isomers possess very similar mol. structures, thus reducing the risk of assembly heterogeneity and facilitating the formation of a homogeneous and consistent liquid crystal mesophase. Meanwhile, a significant electronic effect was caused for fluorophores with positional isomerization, allowing the efficient tuning of emission colors via copolymerization Especially with a gradual change in the composition of the copolymers, the emission color shift behaved in a continuous manner from blue to green. These cyanostilbene-based liquid-crystalline polymers also showed reversible photochromic fluorescence switching ability. This approach highlights the value of positional isomers to prepare color-tunable solid-state light-emitting materials, allowing control and fine-tuning of the emission property while maintaining the ordered assembly ability.

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Synthetic Route of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zu, Pengjiao published the artcileStructure design and performance investigation of 2-mercapto-5-methyl thiadiazole based ionic liquids as lubricants and corrosion inhibitors, Application of 1-Bromododecane, the publication is Tribology International (2022), 107682, database is CAplus.

2-Mercapto-5-methyl-1,3,4-thiadiazole (MMT) based ionic liquids were synthesized, their corrosion inhibition behavior and tribol. performance were systematically evaluated. Electrochem. experiments showed MMT based ILs exhibited surprising corrosion inhibition efficiencies. The ILs adsorption behavior obeys Langmuir isotherm. Friction tests demonstrated MMT based ILs performed excellent lubrication properties, compared to [BMIM][BF4]. Combining with anal. of SEM and XPS, it can be concluded that the prominent lubrication performance ascribed to the coexistence of adsorption layer and tribo-film. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting performance and excellent lubricating properties. This work is instructive for structure design of multifunctional ILs and will promote industrial application of MMT based ILs in the future.

Tribology International published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C7H16ClNO2, Application of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zu, Pengjiao published the artcileStructure design and performance investigation of 2-mercapto-5-methyl thiadiazole based ionic liquids as lubricants and corrosion inhibitors, Safety of 1-Bromooctane, the publication is Tribology International (2022), 107682, database is CAplus.

2-Mercapto-5-methyl-1,3,4-thiadiazole (MMT) based ionic liquids were synthesized, their corrosion inhibition behavior and tribol. performance were systematically evaluated. Electrochem. experiments showed MMT based ILs exhibited surprising corrosion inhibition efficiencies. The ILs adsorption behavior obeys Langmuir isotherm. Friction tests demonstrated MMT based ILs performed excellent lubrication properties, compared to [BMIM][BF4]. Combining with anal. of SEM and XPS, it can be concluded that the prominent lubrication performance ascribed to the coexistence of adsorption layer and tribo-film. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting performance and excellent lubricating properties. This work is instructive for structure design of multifunctional ILs and will promote industrial application of MMT based ILs in the future.

Tribology International published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C6H6N2O, Safety of 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fang, Di published the artcileRadical C(sp³)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols, Synthetic Route of 111-83-1, the publication is Organic Letters (2022), 24(10), 2050-2054, database is CAplus and MEDLINE.

The first radical C(sp³)-H Heck-type reaction of aliphatic alcs. for selective δ- and ε-alkenol I [R = H, Ph, 4-FC₆H₄, etc.; R¹ = Me, n-Bu, Bn, etc.; R² = H, Me; R¹R² = cyclohexyl, cyclopentyl, 2,3-dihydro-1H-inden-2-yl; Ar = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; X = CH₂, O] and II [Ar¹ = Ph, 4-CNC₆H₄, 4-MeOC₆H₄, etc.] synthesis by photoredox catalysis. N-Alkoxybenzimidoyl chlorides were developed as novel alkoxyl radical precursors with tunable redox potentials. Various alkenols could be constructed by the inert C(sp³)-H Heck-type reaction of 4-cyano-N-alkoxybenzimidoyl chlorides with styrene derivatives under redox-neutral conditions, which could be performed on the gram scale and can be easily derivatized.

Organic Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Synthetic Route of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fan, Xiaozhong published the artcileEnantioselective Atropisomeric Anilides Synthesis via Cu-Catalyzed Intramolecular Adjacent C-N Coupling, Safety of 2-Bromo-5-methoxybenzene boronic acid, the publication is ACS Catalysis (2019), 9(3), 2286-2291, database is CAplus.

Catalytically asym. synthesis of atropisomeric compounds is an important research area in organic synthesis. However, in comparison with C-C atropisomers, the atropisomers caused by the restricted rotation of C-N single bonds have been given less attention because of the limited methods for accessing these compounds Herein we report a Cu-catalyzed enantioselective intramol. Ullmann-type amination reaction for the synthesis of C-N atropisomers. The C-N axial chirality was induced highly efficiently by the intramol. adjacent C-N cross-coupling. The readily prepared N,N’-(cyclohexane-1,2-diyl)dipicolinamides showed high efficacy and stereoinduction (up to 99% ee).

ACS Catalysis published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Safety of 2-Bromo-5-methoxybenzene boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary