Month: December 2022

Snider, Barry B. published the artcileControl of the regioselectivity of oxidative free-radical cyclizations by addition to haloalkenes, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of Organic Chemistry (1992), 57(15), 4195-205, database is CAplus.

Chlorine substituents on the alkene control the regioselectivity of the cyclization of 5-hexenyl or 6-heptenyl radicals generated by oxidation of an acetoacetate ester or 1,3-diketone with Mn(OAc)₃·2H₂O. 6-exo-Cyclization of the radicals obtained by oxidation of benzoylacetone derivatives RCOCH₂CO(CH₂)₃CH:CHCl [R = Ph, 2,4-(MeO)₂C₆H₃], containing a chlorine on the terminal double bond carbon, gives α-chloroalkyl radicals that add to the aromatic ring which by elimination of HCl leads to naphthols I (R¹ = H, OMe) indicating that this reaction may be useful for aureolic acid synthesis . exo-Cyclization is the exclusive process with acetoacetates e.g., CH₂:CHCH₂CH(CO₂Me)CO(CH₂)₂CH:CHCl, containing a chlorine on the terminal double bond carbon. 6-endo-Cyclization is the exclusive process with acetoacetates e.g., CH₂:CHCH₂CH(CO₂Me)CO(CH₂)₂CCl:CH₂, containing a chlorine on the internal double bond carbon. Intra- and intermol. competition experiments indicate that these effects are primarily steric. The chlorine substituent controls the regioselectivity of the cyclization by sterically hindering attack of the radical on the chlorine bearing double bond carbon thereby retarding formation of the β-chloroalkyl radical. The chlorine substituent does not electronically accelerate attack on the other end of the double bond to give the α-chloroalkyl radical.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H5Br2F, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Yuchi published the artcileCyclodextrin single isomer-based vesicle for chlorin e6 delivery and enhanced efficiency of photodynamic therapy for cancer treatment, Safety of 1-Bromododecane, the publication is Journal of Molecular Liquids (2022), 118683, database is CAplus.

In the field of cancer therapy, photodynamic therapy (PDT) is an emerging treatment modality that utilized light, photosensitizers (PSs), and oxygen to generate reactive oxygen species (ROS) to destroy tumor sites selectively. Conventional PSs experience issues such as poor water solubility and low bioavailability. The widely developed PS delivery nanosystems can address these problems, but most of them usually depend on relatively complex components and time-consuming synthesis procedures. Therefore, PS delivery vehicles with more easily obtained components and simpler preparation methods need to be explored. In this study, amphiphilic and cationic single-isomer cyclodextrin (CD-IL) was designed, which could co-assemble with chlorin e6 (Ce6, a com. available PS) via multiple non-covalent interactions. The obtained nanovesicles (CD-CE) could not only overcome the inherent drawbacks of free Ce6, but also exhibit improved PDT efficacy in a series of cell-related experiments, including favorable stability, preferable cellular uptake, and enhanced phototoxicity. Thus, CD-CE prepared by the co-assembly of simple building blocks could be a facile option for PDT clin. applications.

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is CBF6K, Safety of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Wentian published the artcileDesign and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC), SDS of cas: 69361-41-7, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5217-5241, database is CAplus and MEDLINE.

Despite advances in targeted anticancer therapies, there are still no small-mol.-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of truncating adenomatous polyposis coli (APC)-selective inhibitor 1 (TASIN-1), a small mol. that specifically targets colorectal cancer cells lines with truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor gene through inhibition of cholesterol biosynthesis. Here, we report a medicinal chem. evaluation of a collection of TASIN analogs and activity against colon cancer cell lines and an isogenic cell line pair reporting on the status of APC-dependent selectivity. A number of potent and selective analogs were identified, including compounds with good metabolic stability and pharmacokinetic properties. The compounds reported herein represent a first-in-class genotype-selective series that specifically target apc mutations present in the majority of CRC patients and serve as a translational platform toward a targeted therapy for colon cancer.

Journal of Medicinal Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C14H26O2, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tang, Yixiao published the artcileBlack-to-transmissive polymer films via electrochemical copolymerization with high-performance electrochromic and supercapacitor bifunction, Recommanded Product: 1-Bromododecane, the publication is Solar Energy Materials & Solar Cells (2022), 111857, database is CAplus.

The black-to-transmissive electrochromic polymer has significant value with practical applications. Integration of electrochromic and supercapacitor bifunctional materials can indicate its capacitor level by visual color change in real-time. In this paper, based on three EDOT derivative monomers were associated to phenanthrocarbazole/benzotriazole/benzothiadiazole, M1, M2 and M3, a novel ternary random copolymer film was successfully prepared by electrochem. copolymerization Since the corresponding homopolymers of three monomers are red, green and blue in the neutral state resp., and their oxidation states are all transparent, therefore the obtained ternary random copolymer films show the black-to-transmissive electrochromic behavior. The copolymer film pCo-2 was prepared via electrochem. copolymerization with suitable monomers feed ratio (1: 1.5: 1 of M1: M2: M3). Benefit from ternary random electrochem. copolymerization, the pCo-2 copolymer displays excellent electrochromic-supercapacitor properties among the similar bifunctional materials, with fast response time, high optical contrast, good cycling stability and large area (volume) specific capacitance. The electrochromic supercapacitor device based on pCo-2//PEDOT can make an LCD run continuously. This work provides an available general approach to realizing black-to-transmissive electrochromism towards electrochromic-supercapacitor bifunctional applications.

Solar Energy Materials & Solar Cells published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C3H6O2, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Coombs, John R. published the artcileEnantiomerically Enriched Tris(boronates): Readily Accessible Conjunctive Reagents for Asymmetric Synthesis, SDS of cas: 81216-14-0, the publication is Journal of the American Chemical Society (2014), 136(46), 16140-16143, database is CAplus and MEDLINE.

The catalytic enantioselective diboration of vinyl boronate esters furnishes chiral tris(boronates) in a selective fashion. Subsequent deborylative alkylation occurs in a diastereoselective fashion, both for intermol. and intramol. processes.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, SDS of cas: 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fu, Jie published the artcileUltralow-cost portable device for cesium detection via perovskite fluorescence, Recommanded Product: 1-Bromooctane, the publication is Journal of Hazardous Materials (2022), 127981, database is CAplus and MEDLINE.

Public anxiety and concern from cesium pollution in oceans have been back on the agenda since tons of nuclear waste water were announced to be poured into oceans. Cesium ion can easily enter organisms and bioaccumulate in animals and plants, thus its harm is chronic to humans through food chains. Here we showed a kind of hybrid ionic liquid membrane (HILM) for detection of cesium ion in seawater through CsPbBr₃ perovskite fluorescence. With sustainability in mind, HILM was built frugally. The lowest cost of HILM is below 3 cents per piece. The HILM can detect cesium ion quickly with eye-readable fluorescence signal. Ultracheap, portable, easy-to-use on-site detection device could offer benefit for personal security and applications in environment science and ecol. in the future decades.

Journal of Hazardous Materials published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gao, Heqi published the artcileA dentin hypersensitivity treatment using highly stable photothermal conversion nanoparticles, Name: 2-Bromo-3-(2-ethylhexyl)thiophene, the publication is Materials Chemistry Frontiers (2021), 5(8), 3388-3395, database is CAplus.

Most of the currently available com. photothermal agents suffer from issues in terms of photothermal instability and low photothermal conversion efficiency (PCE), which indeed impair their practical applications in disease treatment. Herein, a type of biocompatible organic nanoparticles (namely NDTB NPs) for an effective photothermal treatment with a high PCE of 40.6% was developed, which showed far higher photothermal stability compared with that of the clin. used indocyanine green. In addition, NDTB NPs combined with laser are significantly more effective than only laser irradiation in phototheranostic dental hypersensitivity treatments. This study thus provides an insight into the development of advanced photothermal NPs for practical phototheranostic applications.

Materials Chemistry Frontiers published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Name: 2-Bromo-3-(2-ethylhexyl)thiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Yan published the artcileSynthesis of Difluoromethylated and Phosphorated Spiro[5.5]trienones via Dearomative Spirocyclization of Biaryl Ynones, Related Products of bromides-buliding-blocks, the publication is Organic Letters (2018), 20(10), 2988-2992, database is CAplus and MEDLINE.

Copper- or silver-catalyzed cascade radical addition/dearomative spirocyclization of biaryl ynones with fluoroalkyl bromides or diethylphosphite has been realized for the first time. This method provides a novel and step-economical protocol for the divergent synthesis of a wide range of difluoromethylated or monofluoromethylated and phosphorated spiro[5.5]trienones in moderate to high yields.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C10H18O4, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shang, Tianbo published the artcilePhotocatalytic Remote Oxyfluoroalkylation of Heteroalkynes: Regio-, Stereo-, and Site-Selective Access to Complex Fluoroalkylated (Z)-Alkenes, Safety of Ethylbromofluoroacetate, the publication is Organic Letters (2020), 22(9), 3667-3672, database is CAplus and MEDLINE.

A visible-light-induced remote oxyfluoroalkylation, including ketofluoroalkylation and hydroxytrifluoromethylation, of heteroalkynes is developed with DMSO (DMSO) and H₂O as the oxygen source, resp. It provides a facile access to complex fluoroalkylated (Z)-alkenes in satisfactory yields with excellent regio-, stereo-, and site-selectivity. The reaction involves an uncommon vinyl radical-induced intermol. C(sp³)-H functionalization, thus offering a good platform for the development of remote difunctionalization of alkynes.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C6H6BClO3, Safety of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tao, Jiayu published the artcileTwo asymmetrical perylene diimide derivatives: Synthesis, optical-electrochemical properties and morphologies of self-assembly, Recommanded Product: 1-Bromododecane, the publication is Journal of Solid State Chemistry (2022), 122665, database is CAplus.

In this manuscript, two PDI derivatives I [X = N] and I [X = O] with unsym. N-substitution of amine and ester-bridge were designed and synthesized. These two compounds were characterized by NMR, Fourier transform IR (FT-IR), and high-resolution mass spectrometry (HRMS). The photophys. properties were studied by UV-Vis absorption and fluorescence spectroscopy. Cyclic voltammograms of I [X = N] and I [X = O] were investigated and HOMO and LUMO energy levels of both two PDIs were estimated as -6.2 and -3.9 eV, resp. Thermal properties were also studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). I [X = N] was assembled into nanotubes while I [X = O] was assembled into nanobelts resp., via a reprecipitation method. I [X = N] and I [X = O] show good potential application in organic devices such as solar cells, organic field-effect transistors (OFETs) and so on.

Journal of Solid State Chemistry published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C13H9FO2, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary