Month: December 2022

Wang, Shuaifeng published the artcilePalladium-Catalyzed anti-Selective Fluoroalkylboration of Internal and Terminal Alkynes, Safety of Ethylbromofluoroacetate, the publication is Organic Letters (2018), 20(18), 5631-5635, database is CAplus and MEDLINE.

A Pd-catalyzed anti-stereospecific alkyne fluoroalkylboration, including mono-, di-, and perfluoroalkylboration, has been developed with fluoroalkyl halides and diboron reagents. The reaction is effective for both internal and terminal alkynes. It provides straightforward and streamlined access to functionalized 1,2-fluoroalkylboronated alkenes in a highly regio- and stereocontrolled manner. Preliminary studies suggest that this reaction is enabled by the combination of radical alkylation and metal-catalyzed borylation, thus leading to the realization of three-component trans-carboboration of alkynes for the first time.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C22H12F6O6S2, Safety of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Min published the artcileRadical Monofluoroalkylative Alkynylation of Olefins by a Docking-Migration Strategy, HPLC of Formula: 401-55-8, the publication is Angewandte Chemie, International Edition (2019), 58(49), 17646-17650, database is CAplus and MEDLINE.

A radical-mediated monofluoroalkylative alkynylation of alkenes is disclosed for the first time. The reaction demonstrates a remarkably broad substrate scope in which both activated and unactivated alkenes are suitable starting materials. The concurrent addition of an alkynyl and a monofluoroalkyl group onto an alkene proceeds through a docking-migration sequence, affording a vast array of valuable fluoroalkyl-substituted alkynes. Many complex natural products and drug derivatives are readily functionalized, demonstrating that this method can be used for late-stage alkynylation.

Angewandte Chemie, International Edition published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C9H5ClO4S, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Yun published the artcileNickel-Catalyzed Monofluoroalkylation of Arylsilanes via Hiyama Cross-Coupling, Application In Synthesis of 401-55-8, the publication is Organic Letters (2016), 18(21), 5564-5567, database is CAplus and MEDLINE.

The first example of nickel-catalyzed monofluoroalkylation of arylsilanes has been developed with readily available fluoroalkyl halides. This novel transformation has demonstrated high reactivity, broad substrate scope, excellent functional group tolerance, and mild reaction conditions. The selective activation of a relatively inert C-Si bond for slow release of aryl carbanion is the key reason for reducing the amount of arylmetal species, which makes this method more promising for fluorine-containing modification of complex bioactive mols. Mechanistic investigations indicate that a free fluoroalkyl radical is involved in this catalytic cycle.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C6H12O2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, En-si published the artcileSynthesis of a new antiviral medicine famciclovir, Product Details of C8H15BrO2, the publication is Jilin Daxue Ziran Kexue Xuebao (2000), 95-98, database is CAplus.

The title compound was prepared with 21 % yield via regioselective alkylation of 2-aminopurine with 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxan as a pivotal step. The route without highly toxic reagents and high presure and temperature may be applied to industrial production

Jilin Daxue Ziran Kexue Xuebao published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C10H14N2O, Product Details of C8H15BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yao, Zhaoyang published the artcileConformational and compositional tuning of phenanthrocarbazole-based dopant-free hole-transport polymers boosting performance of perovskite solar cells, Quality Control of 303734-52-3, the publication is Journal of the American Chemical Society (2020), 142(41), 17681-17692, database is CAplus and MEDLINE.

Conjugated polymers are regarded as promising candidates for dopant-free hole-transport materials (HTMs) in efficient and stable perovskite solar cells (PSCs). Thus far, the vast majority of polymeric HTMs feature structurally complicated benzo[1,2-b:4,5-b′]dithiophene (BDT) analogs and electron-withdrawing heterocycles, forming a strong donor-acceptor (D-A) structure. Herein, a new class of phenanthrocarbazole (PC)-based polymeric HTMs (PC1, PC2, and PC3) has been synthesized by inserting a PC unit into a polymeric thiophene or selenophene chain with the aim of enhancing the π-π stacking of adjacent polymer chains and also to efficiently interact with the perovskite surface through the broad and planar conjugated backbone of the PC. Suitable energy levels, excellent thermostability, and humidity resistivity together with remarkable photoelec. properties are obtained via meticulously tuning the conformation and elemental composition of the polymers. As a result, PSCs containing PC3 as dopant-free HTM show a stabilized power conversion efficiency (PCE) of 20.8% and significantly enhanced longevity, rendering one of the best types of PSCs based on dopant-free HTMs. Subsequent exptl. and theor. studies reveal that the planar conformation of the polymers contributes to an ordered and face-on stacking of the polymer chains. Furthermore, introduction of the “Lewis soft” selenium atom can passivate surface trap sites of perovskite films by Pb-Se interaction and facilitate the interfacial charge separation significantly. This work reveals the guiding principles for rational design of dopant-free polymeric HTMs and also inspires rational exploration of small mol. HTMs.

Journal of the American Chemical Society published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C18H17NO8, Quality Control of 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yao, Zhaoyang published the artcilePyrene-Based Dopant-Free Hole-Transport Polymers with Fluorine-Induced Favorable Molecular Stacking Enable Efficient Perovskite Solar Cells, Category: bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(24), e202201847, database is CAplus and MEDLINE.

A new class of polymeric hole-transport materials (HTMs) are explored by inserting a two-dimensionally conjugated fluoro-substituted pyrene into thiophene and selenophene polymeric chains. The broad conjugated plane of pyrene and “Lewis soft” selenium atoms not only enhance the π-π stacking of HTM mols. greatly but also render a strong interaction with the perovskite surface, leading to an efficient charge transport/transfer in both the HTM layer and the perovskite/HTM interface. Note that fluorine substitution adjacent to pyrene boosts the stacking of HTMs towards a more favorable face-on orientation, further facilitating the efficient charge transport. As a result, perovskite solar cells (PSCs) employing PE10 as dopant-free HTM afford an excellent efficiency of 22.3 % and the dramatically enhanced device longevity, qualifying it among the best PSCs based on dopant-free HTMs.

Angewandte Chemie, International Edition published new progress about 1998-61-4. 1998-61-4 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzene,Phenol, name is 4-Bromo-2,3,5,6-tetrafluorophenol, and the molecular formula is C11H10O, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Zi-Lu published the artcileCopper-Catalyzed Anti-Markovnikov Hydrosilylation of Terminal Alkynes, Safety of 7-Bromohept-1-yne, the publication is Organic Letters (2020), 22(19), 7735-7742, database is CAplus and MEDLINE.

A Cu-catalyzed anti-Markovnikov hydrosilylation of alkynes with PhSiH₃ is reported. This reaction represents a notable and efficient example on Cu-catalyzed hydrosilylation of alkynes, which shows excellent recognition between the terminal and internal triple bonds. Various (hetero)aromatic and aliphatic substituted terminal alkynes underwent this reaction to afford the (E)-vinylsilanes in high yields and with excellent regioselectivity.

Organic Letters published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C8H6ClF3, Safety of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Feng, Jian published the artcileCopper-Catalyzed 1,2,5-Trifunctionalization of Terminal Alkynes Using SR as a Transient Directing Group for Radical Translocation, Synthetic Route of 81216-14-0, the publication is Chinese Journal of Chemistry (2022), 40(14), 1667-1673, database is CAplus.

The first Cu-catalyzed 1,2,5-trifunctionalization of abundant terminal alkynes is realized by merging hydrogen atom transfer and traceless directing strategy with SR as a transient group, delivering highly functionalized aldehydes in moderate to excellent yields with broad substrate scope. The synthetic utility of this method was demonstrated by the gram-scale reaction and downstream transformations of the resultant products. Given the high efficient installation of three different functional groups in a single reaction, it can serve as a very attractive method for rapidly assembling complex mols. from readily available starting materials.

Chinese Journal of Chemistry published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Synthetic Route of 81216-14-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tan, Wei published the artcile4-N-Methyl-N’-(2-dihydroxyboryl-benzyl)amino benzonitrile and its boronate analogue sensing saccharides and fluoride ion, Category: bromides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(9), 2629-2633, database is CAplus and MEDLINE.

Two DMABN (4-N,N-dimethylaminobenzonitrile) derivatives were designed as new ratiometric fluorescent sensors for saccharides and fluoride ion (F^–), resp., based on the TICT (twisted intramol. charge transfer) mechanism.

Bioorganic & Medicinal Chemistry Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C11H8O3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Lin published the artcileA Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease, Product Details of C7H13BrSi, the publication is Angewandte Chemie, International Edition (2015), 54(37), 10821-10825, database is CAplus and MEDLINE.

The design of the first dual-purpose activity-based probe of monoamine oxidase B (MAO-B) is reported. This probe is highly selective towards MAO-B, even at high MAO-A expression levels, and could sensitively report endogenous MAO-B activities by both in situ proteome profiling and live-cell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far: the live-cell imaging of MAO-B activities without encountering diffusion problems.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary