Month: December 2022

Stork, Gilbert published the artcileThe Total Synthesis of a Natural Cardenolide: (+)-Digitoxigenin, Product Details of C7H13BrSi, the publication is Journal of the American Chemical Society (1996), 118(43), 10660-10661, database is CAplus.

The authors report the total synthesis of natural (+)-digitoxigenin (I), the biol. active cardenolide which, as its trisaccharide derivative digitoxin, is one of the most frequently used of the active principles isolated from Digitalis species. I was prepared from chiral decalone II via octahydrophrenanthrenone III (TBS = Me₃CSiMe₂) and steroidal aldehyde IV.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C17H37NO3, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Brase, Stefan published the artcileIntramolecular Heck couplings and cycloisomerizations of bromodienes and enynes with 1′,1′-disubstituted methylenecyclopropane terminators: Efficient syntheses of [3]dendralenes, Application In Synthesis of 69361-41-7, the publication is European Journal of Organic Chemistry (2005), 4167-4178, database is CAplus.

2-Bromoalka-1,n-dienes, e.g. I, with tetrasubstituted methylenecyclopropane end groups, under palladium catalysis, underwent cyclization with cyclopropane-ring opening to give 2-ethenyl-3-methylene-1-cycloalkenes, e.g. II, which are substituted monocyclic [3]dendralenes. The same cross-conjugated trienes were isolated in good to excellent yields (77-92 %) from the corresponding 1,6- (e.g. III) and 1,7-enynes by a more atom-economic, palladium-catalyzed cycloisomerization. The vinylpalladium halide intermediate generated by initial carbopalladation of the 1,6-enyne III with in situ generated phenylpalladium iodide also underwent the same cyclization cascade to yield the correspondingly phenyl-substituted cyclic [3]dendralene. The palladium-catalyzed cycloisomerization of an alk-1-ene-7,12-diyne gave the bicyclic cross-conjugated tetraene. Key features of the mechanism of the palladium-catalyzed cycloisomerization were proved using a specially designed model system. Like other cyclic [3]dendralenes, the ethenyl(methylene)cycloheptene IV underwent a domino-Diels-Alder reaction with N-phenyltriazoline-3,5-dione to give a single diastereomer of the pentacyclic heterocycle.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application In Synthesis of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bernd, Johannes published the artcileElectrochemical O-trifluoromethylation of electron-deficient phenols, Name: 4-Bromo-2,3,5,6-tetrafluorophenol, the publication is Electrochemistry Communications (2021), 107165, database is CAplus.

A simple and sustainable one-step strategy for the preparation of electron-deficient aryl trifluoromethyl ethers (ArOCF₃) from the corresponding phenols by electrochem. synthesis is presented. Anodic oxidation of trifluoromethane sulfinate (Langlois reagent) leads to direct O-trifluoromethylation of phenol-derivatives bearing fluorine, chlorine, bromine and nitrile substituents under mild conditions in yields up to 75% and in gram-scale. This electrochem. protocol provides an economic and green synthesis for an otherwise inaccessible class of mols. without the need for expensive or toxic reagents, oxidants or metal catalysts.

Electrochemistry Communications published new progress about 1998-61-4. 1998-61-4 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzene,Phenol, name is 4-Bromo-2,3,5,6-tetrafluorophenol, and the molecular formula is C6HBrF4O, Name: 4-Bromo-2,3,5,6-tetrafluorophenol.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Natrajan, Anand published the artcileA green synthesis of chemiluminescent N-sulfopropyl acridinium esters in ionic liquids without using the carcinogen 1,3-propane sultone, Formula: C3H6BrNaO3S, the publication is Green Chemistry Letters and Reviews (2013), 6(3), 237-248, database is CAplus.

Chemiluminescent acridinium dimethylphenyl esters containing hydrophilic N-sulfopropyl groups in the acridinium ring are used as labels in automated immunoassays for clin. diagnostics. Introduction of the N-sulfopropyl group in these labels is normally accomplished by N-alkylation of the corresponding, nonchemiluminescent acridine ester precursors with the toxic carcinogen 1,3-propane sultone. In the current study, we report that sodium 3-bromopropane sulfonate in ionic liquids (ILs) is a benign alternative to 1,3-propane sultone for introducing the N-sulfopropyl group in chemiluminescent acridinium ester labels. The sultone reagent can be eliminated in the synthesis of N-sulfopropyl acridinium dimethylphenyl ester labels by taking advantage of the increased reactivity of acridan esters toward nontoxic sodium 3-bromopropane sulfonate in [BMIM][BF₄]. Sodium 3-bromopropane sulfonate in ILs is also potentially a nontoxic alternative to 1,3-propane sultone for introducing the water-soluble, three-carbon sulfobetaine moiety in other mols. as well.

Green Chemistry Letters and Reviews published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Formula: C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bhaumik, Jayeeta published the artcileSynthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers, HPLC of Formula: 55788-44-8, the publication is Journal of Organic Chemistry (2009), 74(16), 5894-5901, database is CAplus and MEDLINE.

2,4-Dinitrophenylsulfonamido-substituted tetraphenylporphyrins with varying polarities or with functionality to allow conjugation to biomols. are prepared The fluorescence quantum yields of the dinitrophenylsulfonamido-substituted tetraphenylporphyrins and their parent amino-substituted tetraphenylporphyrins are determined; the kinetics of the cleavage of the dinitrophenylsulfonyl groups by small mol. thiols and the chemoselectivity of cleavage are also determined

Journal of Organic Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, HPLC of Formula: 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bauer, Heiko published the artcileChromocene, ferrocene, cobaltocene, and nickelocene derivatives with isopropyl and methyl or trimethylsilyl substituents, Application of Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Journal of Organometallic Chemistry (2016), 63-73, database is CAplus.

From sodium 2,3-diisopropyl-1,4-dimethyl-cyclopentadienide and MBr₂(dme) (M = Fe, Co, Ni) the corresponding ferrocene (1), cobaltocene (2) and nickelocene (3) could be obtained as pure, crystalline solids. From an analogous reaction of sodium 2,3,5-triisopropyl-1,4-dimethyl-cyclopentadienide with FeCl₂, only the mixed-substituted ferrocene (³₂Cp)(²₂Cp)Fe (4) could be crystallized (³₂Cp = 2,3,5-triisopropyl-1,4-dimethyl-cyclopentadienyl, ²₂Cp = 2,3-diisopropyl-1,4-dimethyl-cyclopentadienyl). The trimethylsilyl substituted ferrocene (5) and nickelocene (6) were synthesized from the corresponding metal halides and potassium 2,3-diisopropyl-1,4-dimethyl-5-trimethylsilyl-cyclopentadienide as well as a series of chromocenes with silylated or alkylated cyclopentadienyl ligands (7–10) from chromium(II) acetate. Octaisopropylnickelocene (11) has been obtained and converted to octaisopropylnickelocenium hexafluorophosphate (12). 1,2,3,4-Tetraisopropylnickelocenium tetrabromoaluminate (13) was obtained from tetraisopropylcyclopentadienylnickel(II) tetrabromoaluminate and nickelocene. Crystal structures have been obtained for metallocenes 1–5, 7–9, and 11.

Journal of Organometallic Chemistry published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Application of Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bernstein, A. published the artcileSynthesis and stability of triorganostannylalkylsulfonic acids, Recommanded Product: Sodium 3-bromopropane-1-sulfonate, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1991), 41-7, database is CAplus.

Sodium triorganostannylalkylsulfonates R₃Sn(CH₂)_nSO₃Na (I, R = Me, Ph, n = 2,3) are obtained by reaction of triorganostannylsodium with sodium haloalkylsulfonates or propane solution in liquid ammonia. I can be converted by ion-exchange in the free sulfonic acids R₃Sn(CH₂)_nSO₃H which are of limited stability and undergo cyclocondensation reactions with formation of the cyclic triorganotin alkanesulfonates II (R = Me, Ph, n = 1, 2).

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Recommanded Product: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhai, Lipeng published the artcileCationic Covalent Organic Frameworks for Fabricating an Efficient Triboelectric Nanogenerator, SDS of cas: 518-67-2, the publication is ACS Materials Letters (2020), 2(12), 1691-1697, database is CAplus.

Covalent organic frameworks (COFs) have developed as a precisely tailor-made platform for integrating different functionalities into the frameworks via reticular chem. In this work, two COFs with a similar topol. and skeleton but different charge state over the skeleton are designed and applied to clarify the contributions of cationic groups to the output performance of a triboelec. nanogenerator (TENG). The cationic functional centers are distributed alternately over both sides of the pore channels. The cationic COF possesses unconventional electrostatic functions due to the ionic interface over the skeletons. The output performance of a cationic COF decorated with an elec.-dipole-based TENG is improved by a 2-fold contrast to the neutral analog. Moreover, a cationic COF-based TENG is further employed to charge com. capacitors (0.1 F), light up light-emitting diodes (LEDs), and power a stopwatch. This work illustrates the facile construction of a cationic COF and its application in fabricating a TENG, generating an ecofriendly and excellent-performance energy harvesting and self-powered device.

ACS Materials Letters published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C5H10Cl3O3P, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Mengyu published the artcileConverting thermally activated delayed fluorescence into hybridized local and charge-transfer via an addition acceptor moiety, COA of Formula: C12H25Br, the publication is Organic Electronics (2022), 106365, database is CAplus.

High-efficiency blue materials for Organic Light Emitting Diodes (OLEDs) are challenging but urgently needed, especially for solution-processed devices. Herein, based on a model compound of acridine-benzophenone, two blue materials were designed and synthesized, with the addnl. electron-withdrawing groups benzophenone and pentafluorobenzophenone connected to the acridine donor resp. to prepare BC and BC5F. The solution-processed OLED based on BC showed an emission peak at 486 nm, while the device with BC5F showed the electroluminescent peak at 478 nm. BC featured the thermally active delayed fluorescent (TADF) properties, but BC5F exhibited hybridized local and charge-transferring (HLCT) characteristics. This work showed that linking addnl. acceptors to the donor side could not only achieve deeper blue emission but also change the luminescent mechanism. Therefore, we provided a new strategy to manipulate the transition between TADF and HLCT.

Organic Electronics published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C5H9IO2, COA of Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Horii, Zenichi published the artcileSyntheses of oxytocics. II. Synthesis of 2-[(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionic acid derivatives, Category: bromides-buliding-blocks, the publication is Yakugaku Zasshi (1961), 1786-91, database is CAplus and MEDLINE.

cf. ibid. 83,706-10(1962); CA 55, 23560d. 1,2,3,4-Tetrahydro-2-naphthylamine (29.4 g.), 80.8 g. CH₂:CMeCO₂Me, and 100 ml. MeOH refluxed 28 hrs. and the product distilled gave 38 g. Me 2-[(1,2,3,4-tetrahydro-2-naphthyl)-aminomethyl]propionate (I), b_0.02 126°. Saponification of 4.9 g. I in 50 ml. 3% KOH by refluxing 30 min., washing the solution with Et₂O and neutralization with 10% HCl gave 3.3 g. free acid (II) of I, m. 185-6° (EtOH). Catalytic reduction of 4.8 g. I in 4.4 g. 37% HCHO and 20 ml. MeOH with 2.5 g. 10% Pd-C, removing of the MeOH, removing of non-methylated NH₂ (II) by acetylation with Ac₂O, alkalizing with K₂CO₃, and extracting the product with Et₂O gave 3.5 g. Me 2-[N-methyl-(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionate (III), b_0.06 137-8°. Saponification of 1.3 g. III in 10 ml. 10% KOH by refluxing 4-5 hrs. and neutralization with 10% HCl to pH 6 gave 0.6 g. of the free acid (IV) of III, sublimed at 100-20°/0.1 mm., m. 123-5°. IV (0.5 g.) in 5 ml. MeOH treated dropwise with HCl in Et₂O and the solvent removed gave N-methyl-(1,2,3,4-tetrahydro-2-naphthyl)amine-HCl (V), m. 212°. A mixture of 16.1 g. V, 20 ml. EtOH, 45.6 g. CH₂:CMeCO₂Et and 1-2 drops AcOH refluxed 100 hrs. and the product distilled gave 2.3 g. Et ester (VI) of IV, b_0.03 118-23°. I (4.9 g.) and 50 ml. MeOH saturated with NH₃ at 0° in autoclave heated 8 hrs. at 120-30° and the product distilled gave 2.3 g. 2-[(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionamide, m. 91-2° (AcOEt). MeCH(CH₂Br)CO₂H, b₁₄ 115°. MeCH(CH₂Br)COCl, b₂₇ 72-3°. MeCH(CH₂Br)CONHPh, m. 109-11° (EtOH-H₂O). MeCH(CH₂Br)CONMe₂ (VII), b₃ 94-5°. MeCH(CH₂Br)CONEt₂ (VIII), b_0.2 85°. 1,2,3,4-Tetrahydro-2-naphthylamine (IX) (14.7 g.) and 9.7 g. VII in 50 ml. CHCl₃ refluxed 4 hrs., the solution filtered and the filtrate extracted with 10% HCl gave 3.4 g. N,N-dimethyl-2-[(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionamide (X), b_0.01 168-70°. Similarly, 11.7 g. IX and 8.8 g. VIII gave 7 g. N,N-di-Et analog of X, b_0.05 205-20°. IX (14.7 g.) and 10 g. CH₂:CHCO₂Me in 100 ml. MeOH kept 3 days at room temperature gave 21 g. N-(1,2,3,4-tetrahydro-2-naphthyl)-β-alanine Me ester, b_0.1 154-7°; HCl salt, m. 152-3°.

Yakugaku Zasshi published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary