Month: December 2022

Allan, Robin D. published the artcileFacile synthesis of B-phenylethylamine derivatives related to baclofen via aziridine ring opening, HPLC of Formula: 66197-72-6, the publication is Australian Journal of Chemistry (1990), 43(6), 1123-7, database is CAplus.

Nucleophilic ring opening of the protonated salt of 2-(4-chlorophenyl)aziridine with substituted thiols provides a very simple route to β-phenylethylamine derivatives which are analogs of the GAGA_B receptor agonist baclofen and its antagonists phaclofen and saclofen. The condensation-ring opening reaction of thiols with 2-(4-chlorophenyl)aziridine gave H₂NCH₂CH(C₆H₄Cl-4)S(CH₂)_nR (R = CO₂H, PO₃H₂, SO₃H; n = 1,2).

Australian Journal of Chemistry published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, HPLC of Formula: 66197-72-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Steytler, David C. published the artcileMechanisms of Solute Interfacial Transfer in Winsor-II Systems, Category: bromides-buliding-blocks, the publication is Langmuir (2001), 17(2), 417-426, database is CAplus.

The forward transfer kinetics of a water-soluble cationic dye (dimidium) across the planar interface from a conjugate aqueous phase to a water-in-oil (w/o) microemulsion phase (formed using the anionic surfactant Aerosol-OT) have been investigated by means of a rotating diffusion cell. By measurement of the solute flux as a function of rotation speed of the diffusion cell membrane, the influence of mass transport effects to and from the interface could be controlled and eliminated by extrapolation to infinite rotation speed. The rate of forward transfer was linearly proportional to the concentration of solute in the aqueous phase; i.e., it was not possible to saturate the aqueous side of the interface. The rate, however, was found to reach a limiting value on increasing the concentration of nano water droplets in the microemulsion phase. This is explained by a transport model in which the dye initially partitions to the aqueous side of the interface; it then enters the organic phase inside a forming water droplet. The rate of back transfer of H⁺ from a microemulsion droplet phase into a coexisting water phase has also been studied as a function of droplet concentration and temperature These results extend previous measurements on the same system. It is shown that enthalpy-entropy compensation effects operate for the rate-determining step. In the proposed model for defining dynamics of interface transfer from or to an aqueous phase in Winsor-II systems, the rate-determining step is the same for forward and back transfer and is concerned with droplet coalescence with the interface.

Langmuir published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C15H21BO3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tlach, Brian C. published the artcileEffect of Extended Conjugation on the Optoelectronic Properties of Benzo[1,2-d:4,5-d’]bisoxazole Polymers, SDS of cas: 303734-52-3, the publication is Australian Journal of Chemistry (2014), 67(5), 711-721, database is CAplus.

Four copolymers comprising benzo[1,2-d:4,5-d’]bisoxazole (BBO) and benzo[1,2-b:4,5-b’]dithiophene (BDT) bearing phenylethynyl substituents on either the BBO, BDT moieties or both units were synthesized and the influence of two-dimensional conjugation on their optoelectronic properties investigated. Extending conjugation along the BBO resulted in a 0.5eV decrease in the LUMO level, whereas the HOMO level was raised by 0.2eV. Extending conjugation across the BDT moiety in also resulted in a 0.5eV decrease in the LUMO level, however, the effect was negligible on the HOMO level. Thus, cross-conjugation can be used to independently tune the LUMO level within these systems.

Australian Journal of Chemistry published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C5H10Cl3O3P, SDS of cas: 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cardenas, Mariel M. published the artcileEnantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution, Related Products of bromides-buliding-blocks, the publication is Organic Letters (2018), 20(7), 2037-2041, database is CAplus and MEDLINE.

The catalytic enantioselective synthesis of 3-aryl-substituted pyrrolopyrimidines (PPYs), a common motif in drug discovery, is achieved through a kinetic resolution via quaternary ammonium salt-catalyzed nucleophilic aromatic substitution (S_NAr). Both enantioenriched products and starting materials can be functionalized with no observed racemization to give enantiodivergent access to diverse chiral analogs of an important class of kinase inhibitor. One of the compounds was found to be a potent and selective inhibitor of breast tumor kinase.

Organic Letters published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Kenan published the artcileAB-Versus AA+BB-Suzuki Polycondensation: A Palladium/Tris(tert-butyl)phosphine Catalyst Can Outperform Conventional Catalysts, Name: 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Macromolecular Rapid Communications (2020), 41(1), 1900521, database is CAplus and MEDLINE.

A Pd/Pt-Bu₃ catalyst having bulky, electron-rich ligands significantly outperforms conventional “step-growth catalysts” Pd(PPh₃)₄ and Pd(Po-Tol₃)₃ in the suzuki polycondensation of the AB-type arylene-based monomers, such as some of the substituted fluorenes, carbazoles, and phenylenes. In the AA+BB polycondensation, Pd/Pt-Bu₃ also performs better under homogeneous reaction conditions, in combination with the organic base Et₄NOH. The superior performance of Pd/Pt-Bu₃ is discussed in terms of its higher reactivity in the oxidative addition step and inherent advantages of the intramol. catalyst transfer, which is a key step joining catalytic cycles of the AB-polycondensation. These findings are applied to the synthesis of a carbazole-based copolymer designed for the use as a hole conductor in solution-processed organic light-emitting diodes.

Macromolecular Rapid Communications published new progress about 401797-04-4. 401797-04-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic acid and ester, name is 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C5H7NO, Name: 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ho, Hien The published the artcileA post-polymerization functionalization strategy for the synthesis of sulfonyl (trifluoromethanesulfonyl)imide functionalized (co)polymers, Category: bromides-buliding-blocks, the publication is Polymer Chemistry (2017), 8(37), 5660-5665, database is CAplus.

The synthesis of a series of potassium sulfonyl (trifluoromethanesulfonyl)imide (STFSI) derivatives, bearing at one extremity the STFSI group and at the other extremity either bromo, azido or amine groups, is reported. The resultant STFSI derivatives were subsequently used in the post-polymerization functionalization of (co)polymers to yield functionalized (co)polymers by exploiting the highly efficient coupling reactions, namely alkylation, amidation and alkyne-azide cycloaddition

Polymer Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caldirola, P. published the artcileSynthesis of [³H]-VUF 4576: a new radiolabeled calcium antagonist, Product Details of C9H8BrF3, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1992), 31(12), 987-93, database is CAplus.

The new radiolabeled [³H]-VUF 4576 (I) was prepared by an easy procedure using com. available C³H₃I. The new radiolabeled ligand [³H]-VUF 4576 belongs to a subclass of prenylamine analogs which interfere with calcium regulated pathways. The compound has been synthesized in order to study the interaction of other compounds with these mechanisms and in particular the site of action of this subclass of calcium entry blockers and calmodulin antagonists (phosphodiesterase inhibitors).

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Product Details of C9H8BrF3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hernandez, Andres S. published the artcileEnantiospecific Synthesis of (+)- and (-)-Ferruginine from L-Glutamic Acid. Synthesis of Tropanes via Intramolecular Iminium Ion Cyclization, Category: bromides-buliding-blocks, the publication is Journal of Organic Chemistry (1996), 61(1), 314-23, database is CAplus.

Iminium ions, generated by decarbonylation of N-benzyl-5-[1-(methoxycarbonyl)-4-oxopentyl]prolines, undergo intramol. cyclization to afford 2,4-disubstituted tropanes in good yields. This transformation is also shown to be a stereospecific reaction. The value of these substituted tropanes has been demonstrated by functional group manipulation, leading to the enantiospecific synthesis of (+)-ferruginine, an alkaloid isolated from Darlinga ferruginea, and its unnatural enantiomer, (-)-ferruginine.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rawale, Dattatraya Gautam published the artcileLinchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins, Formula: C13H17BrO3, the publication is Chemical Science (2021), 12(19), 6732-6736, database is CAplus and MEDLINE.

The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chem. space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity.

Chemical Science published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C13H17BrO3, Formula: C13H17BrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bovonsombat, Pakorn published the artcileRegioselective monobromination of aromatics via a halogen bond acceptor-donor interaction of catalytic thioamide and N-bromosuccinimide, Formula: C10H6Br2, the publication is Tetrahedron (2017), 73(46), 6564-6572, database is CAplus.

Regioselective monobromination of various aromatics was achieved at room temperature using N-bromosuccinimide and 5 mol% of thioamides in acetonitrile. With thiourea as catalyst, activated aromatics, such as anisole, acetanilide, benzamide and phenol analogs containing electron donating or withdrawing groups, were brominated with high regioselectivity. Room temperature brominations of weakly activated aromatics and deactivated 9-fluorenone were accomplished by 5 mol% thioacetamide, higher substrates concentrations and longer reaction times. A backbonding of the bromine lone pairs with the π^*of C=S group and a halogen bond between the halogen bond donor bromine and the halogen bond acceptor sulfur of the thioamide are thought to be the principal interactions and cause of N-bromosuccinimide activation.

Tetrahedron published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Formula: C10H6Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary