Month: December 2022

Griffiths, W. Richard published the artcileThe mass spectra of phosphonyl compounds. Part 3. Dimethyl- and diethylalkane and substituted-methane phosphonates, Name: Diethyl (bromomethyl)phosphonate, the publication is Phosphorus and Sulfur and the Related Elements (1978), 5(1), 101-6, database is CAplus.

The electron impact spectra of 28 related phosphonates were determined Et, Me₂CH, and Me₃C groups which are bound directly to P, fragment to the corresponding alkenes; similar Me₂CH, Me₃C groups in the di-Me esters also fragment to ethylene and propene, resp., i.e., the P-alkyl rearranges with transfer of the elements of a Me group to the P ion. The di-Et alkenephosphonates undergo double H rearrangements of an ethoxy group to give dihydroxyphosphonium ions. The di- and trihydroxyphosphonium ions have a characteristic fragmentation which involves loss of water. This characteristic has been used as evidence for the rearrangement of a phosphacylium ion to a dihydroxyphosphonium ion.

Phosphorus and Sulfur and the Related Elements published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Name: Diethyl (bromomethyl)phosphonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uchikawa, Yuki published the artcileSynthesis and demethylation of 4,22-dimethoxy[2.10]metacyclophan-1-yne with BBr₃ to afford a novel [10](2,9)-5a,11a-benzofuro-5a-bora-11-bromochromenophane, Category: bromides-buliding-blocks, the publication is Canadian Journal of Chemistry (2012), 90(5), 441-449, database is CAplus.

4,22-Dimethoxy[2.10]metacyclophan-1-yne was prepared by bromination of [2.10]metacyclophan-1-ene followed by the dehydrobromination of the bromine adduct with KOBu-t. Treatment of 4,22-Dimethoxy[2.10]metacyclophan-1-yne with BBr₃ in CH₂Cl₂ at room temperature led to the demethylation and a successive intramol. cyclization reaction to afford a novel [10](2,9)-5a,11a-benzofuro-5a-11-bromochromenophane in good yield. Similar treatment of a mixture of the corresponding meso- and dl-1,2-dibromo-4,22-dimethoxy[2.10]metacyclophane with BBr₃ in CH₂Cl₂ under the same conditions described above afforded cis-4b,9b-dihydro[10]benzofuro[3,2-b]benzofuranophane in 83% yield.

Canadian Journal of Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C13H9ClN2O4, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hu, Essa published the artcileDiscovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2008), 51(11), 3065-3068, database is CAplus and MEDLINE.

Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and Src. In vivo efficacy of pyridone 16 (I)by dose-dependent inhibition of histamine release was demonstrated in a rodent pharmacodynamic model of mast cell activation.

Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kolay, Merve published the artcileSynthesis and optical properties of fused aromatic thienopyrazine based π-conjugated polymers, Application In Synthesis of 52431-30-8, the publication is Smart Materials and Structures (2011), 20(7), 075013/1-075013/6, database is CAplus.

Two new polythieno[3,4-b]pyrazine derivatives, poly-10,12-bis(4-hexylthiophen-2-yl)dibenzo[f,h] thieno[3,4-b]quinoxaline (PDBTQ) and poly-8,10-bis(4-hexylthiophen-2-yl)acenaphtho[1,2-b]thieno[3,4-e]pyrazine (PATP) were synthesized by electrochem. polymerization and their electrochem. properties reported. Electroactivity of the monomer and electrochem. redox behavior of its polymers were investigated by cyclic voltammetry. Spectroelectrochem. anal. was performed and the band gaps of the polymers were determined as 2.0 eV and 1.2 eV from the onset of the π-π* transitions of PDBTQ and PATP, resp. The polymer PDBTQ shows multicolored electrochromic behavior with five distinct states-orange (0.0 V), yellow (+0.30 V), brown (+0.50 V), green (+0.65 V), blue-gray (0.80 V); PATP has two distinct colors-transmissive gray (0.0 V) and green (+0.80 V). The polymers revealed superior optical contrast in the near-IR (NIR) region with fast switching times of less than 1 s.

Smart Materials and Structures published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Application In Synthesis of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Esmer, Elif Nazli published the artcileNear infrared electrochromic polymers based on phenazine moieties, Related Products of bromides-buliding-blocks, the publication is Materials Chemistry and Physics (2011), 131(1-2), 519-524, database is CAplus.

New fused-aromatic quinoxaline and thieno[3,4-b]pyrazine based monomers; 10,12-bis(4-hexylthiophen-2-yl)dibenzo[f,h]thieno[3,4-b]quinoxaline (HTBQ) and 10,13-bis(4-hexylthiophen-2-yl)dipyrido[3,2-a:2′,3′-c]phenazine (HTPP) were synthesized. Electrochem. polymerization of HTBQ and HTPP were performed in acetonitrile/dichloromethane (ACN/DCM) solution containing LiClO₄/NaClO₄. Spectroelectrochem. behavior and switching ability of PHTBQ and PHTPP films were investigated by UV-vis spectroscopy. The polymer films showed reversible electrochem. oxidation with high contrast ratios in the NIR region with low switching times. PHTBQ revealed color changes between brick color and green in the reduced and oxidized states. PHTPP changed color from green to gray when the polymer film was switched between its redox states.

Materials Chemistry and Physics published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nobili, Alberto published the artcileSimultaneous Use of in Silico Design and a Correlated Mutation Network as a Tool To Efficiently Guide Enzyme Engineering, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is ChemBioChem (2015), 16(5), 805-810, database is CAplus and MEDLINE.

In order to improve the efficiency of directed evolution experiments, in silico multiple-substrate clustering was combined with an anal. of the variability of natural enzymes within a protein superfamily. This was applied to a Pseudomonas fluorescens esterase (PFE I) targeting the enantioselective hydrolysis of 3-phenylbutyric acid esters. Data reported in the literature for nine substrates were used for the clustering meta-anal. of the docking conformations in wild-type PFE I, and this highlighted a tryptophan residue (W28) as an interesting target. Exploration of the most frequently, naturally occurring amino acids at this position suggested that the reduced flexibility observed in the case of the W28F variant leads to enhancement of the enantioselectivity. This mutant was subsequently combined with mutations identified in a library based on anal. of a correlated mutation network. By interrogation of <80 variants, a mutant with 15-fold improved enantioselectivity was found.

ChemBioChem published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Schneider, Leon N. published the artcileStable and Storable N(CF₃)₂ Transfer Reagents, Formula: C7H5Br2F, the publication is Chemistry – A European Journal (2021), 27(42), 10973-10978, database is CAplus and MEDLINE.

Fluorinated groups are essential for drug design, agrochems., and materials science. The bis(trifluoromethyl)amino group is an example of a stable group that has a high potential. While the number of mols. containing perfluoroalkyl, perfluoroalkoxy, and other fluorinated groups is steadily increasing, examples with the N(CF₃)₂ group are rare. One reason is that transfer reagents are scarce and metal-based storable reagents are unknown. Herein, a set of Cu^I and Ag^I bis(trifluoromethyl)amido complexes stabilized by N- and P-donor ligands with unprecedented stability are presented. The complexes are stable solids that can even be manipulated in air for a short time. They are bis(trifluoromethyl)amination reagents as shown by nucleophilic substitution and Sandmeyer reactions. In addition to a series of benzylbis(trifluoromethyl)amines, 2-bis(trifluoromethyl)amino acetate was obtained, which, upon hydrolysis, gives the fluorinated amino acid-N,N-bis(trifluoromethyl)glycine.

Chemistry – A European Journal published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fujiki, Michiya published the artcileThermo-driven chiroptical switching polysilane featuring 2-cyclopentylethyl side group, Recommanded Product: (2-Bromoethyl)cyclopentane, the publication is Silicon Chemistry (2002), 1(1), 67-72, database is CAplus.

A new rod-like helical polysilane, poly{(S)-3,7-dimethyloctyl(2-cyclopentylethyl)silane}, was found to undergo a thermo-driven, helix-helix transition at -33°C in isooctane associated with the discontinuous changes in the Siσ-Siσ* transition energy and intensity in the transition temperature region. This is the first example of a helix-helix transition polysilane with a cycloalkyl group. A similar rod-like polysilane derivative, poly{(S)-3,7-dimethyloctyl(1-cyclopentylmethyl)silane}, however, did not undergo any helix-helix transition between -61 and 80°C.

Silicon Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Recommanded Product: (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kamachi, Hiroaki published the artcileStructure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity, Synthetic Route of 111865-47-5, the publication is Bioorganic & Medicinal Chemistry (2013), 21(10), 2695-2702, database is CAplus and MEDLINE.

We have recently developed a simplified analog of aplysiatoxin (aplog-1) as an activator of protein kinase C (PKC) with anti-proliferative activity like bryostatin 1. To identify sites in aplog-1 that could be readily modified to optimize therapeutic performance and to develop a mol. probe for examining the analog’s mode of action, substituent effects on the phenol ring were systematically examined Whereas hydrophilic acetamido derivatives were less active than aplog-1 in inhibiting cancer cell growth and binding to PKCδ, introduction of hydrophobic bromine and iodine atoms enhanced both biol. activities. The anti-proliferative activity was found to correlate closely with mol. hydrophobicity, and maximal activity was observed at a log P value of 4.0-4.5. An induction test with Epstein-Barr virus early antigen demonstrated that these derivatives have less tumor-promoting activity in vitro than aplog-1 regardless of the hydrophobicity of their substituents. These results would facilitate rapid preparation of mol. probes to examine the mechanism of the unique biol. activities of aplog-1.

Bioorganic & Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Synthetic Route of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deng, Qinfei published the artcileSynthesis of 6-Fluoroalkyl 6H-Benzo[c]chromenes via Visible-Light-Promoted Radical Addition/Cyclization of Biaryl Vinyl Ethers, SDS of cas: 401-55-8, the publication is Journal of Organic Chemistry (2018), 83(11), 6151-6161, database is CAplus and MEDLINE.

A novel visible-light-promoted cascade cyclization reaction for the synthesis of 6-fluoroalkyl 6H-benzo[c]chromenes has been successfully realized, which was initiated by intermol. radical addition to biaryl vinyl ethers using easily available fluoroalkylated reagents BrCF₂CO₂Et or 2-bromo-2,2-difluoroamides as the sources of fluorinated radicals, followed by the cyclization onto an aromatic ring process. This protocol tolerated a wide range of functional groups and provided the desired products in moderate to good yields.

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary