Water enables an asymmetric cross reaction of α-keto acids with α-keto esters for the synthesis of quaternary isotetronic acids was written by Chen, Ping;Wang, Kai;Zhang, Boyu;Guo, Wengang;Liu, Yan;Li, Can. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 57293-19-3 This article mentions the following:
A water promoted asym. aldol/lactonization/enolization cascade reaction of α-keto acids R1CH2C(O)C(O)OH (R1 = H, Me) and α-keto esters R2C(O)C(O)OC(CH3)3 [R2 = 4-FC6H4(CH2)2, CH2=CH(CH2)2, C6H5CH2O(CH2)3, etc.] was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids I with excellent enantioselectivity. Theor. results indicate that intramol. ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).
1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 57293-19-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary