Aryne-mediated fluorination: Synthesis of fluorinated biaryls via a sequential desilylation-halide elimination-fluoride addition process was written by Diemer, Vincent;Garcia, Juan Sanz;Leroux, Frederic R.;Colobert, Francoise. And the article was included in Journal of Fluorine Chemistry in 2012.HPLC of Formula: 452-62-0 This article mentions the following:
An unusual aryne-mediated fluorination of aromatic ring systems during the desilylation of ortho-bromo-biphenyl-trimethylsilanes with tetrabutylammonium fluoride (TBAF) is described. In situ formation of an aryne and addition of fluoride affords fluorinated biphenyls. The structures have been confirmed by synthesis of authentic samples via Suzuki-Miyaura cross-coupling and X-ray anal. In situ trapping experiments with furan proved the transient formation of aryne by fluoride-induced displacement of the TMS group and subsequent bromide elimination. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0HPLC of Formula: 452-62-0).
3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 452-62-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary