Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors was written by Hartz, Richard A.;Ahuja, Vijay T.;Nara, Susheel J.;Kumar, C. M. Vijaya;Manepalli, Raju K. V. L. P.;Sarvasiddhi, Sarat Kumar;Honkhambe, Swarnamba;Patankar, Vidya;Dasgupta, Bireshwar;Rajamani, Ramkumar;Muckelbauer, Jodi K.;Camac, Daniel M.;Ghosh, Kaushik;Pokross, Matthew;Kiefer, Susan E.;Brown, Jeffrey M.;Hunihan, Lisa;Gulianello, Michael;Lewis, Martin;Lippy, Jonathan S.;Surti, Neha;Hamman, Brian D.;Allen, Jason;Kostich, Walter A.;Bronson, Joanne J.;Macor, John E.;Dzierba, Carolyn D.. And the article was included in Journal of Medicinal Chemistry in 2022.Recommanded Product: 2-Amino-5-bromo-4-methoxybenzoic acid This article mentions the following:
Investigation of the structure-activity relationships (SARs) of substituents on the resultant quinazoline and quinoline ring systems led to the identification of (S)- I =[R1 = CN, R2 = H], a brain-penetrant, AAK1-selective inhibitor with improved enzyme and cellular potency. The synthesis, SAR, and in vivo evaluation of a series of quinazoline and quinoline-based AAK1 inhibitors were described herein. In the experiment, the researchers used many compounds, for example, 2-Amino-5-bromo-4-methoxybenzoic acid (cas: 169045-04-9Recommanded Product: 2-Amino-5-bromo-4-methoxybenzoic acid).
2-Amino-5-bromo-4-methoxybenzoic acid (cas: 169045-04-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 2-Amino-5-bromo-4-methoxybenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary