Synthesis of a series of brominated 1-phenyl-2-pyridylethenes as inhibitors of the protein-tyrosine kinase p56lck was written by He, Hu-Ming;Geahlen, Robert L.;Cushman, Mark. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1994.Product Details of 108940-96-1 This article mentions the following:
A series of brominated 1-phenyl-2-pyridylethenes was prepared and tested for inhibition of p56lck, a protein-tyrosine kinase of the src family which is overexpressed in several lymphomas. The most potent compound of the series proved to be 2-(3,5-dibromo-4-hydroxybenzylidene)-2-(2-pyridyl)acetonitrile. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Product Details of 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary