Laughton, P. M. et al. published their research in Canadian Journal of Chemistry in 1961 | CAS: 4457-67-4

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 4457-67-4

Solvolysis in hydrogen and deuterium oxide. IV. Halides with neighboring groups was written by Laughton, P. M.;Robertson, R. E.. And the article was included in Canadian Journal of Chemistry in 1961.Related Products of 4457-67-4 This article mentions the following:

Rate ratios kD2O÷kH2O were determined for 23 halides with HO, MeO, or halogen substituents, and compared to the data for Me2CHBr at the same temperature The compounds fell into 3 classes: normal, including compounds showing no anchimeric assistance and the dihalides; low ratios, including compounds assisted by an adjacent HO group [HOCMe2CH2Cl (I) and Br, HOCMe2CHMeCl and Br, and trans-cyclohexene bromohydrin]; high ratios, including HO(CH2)4Cl and compounds assisted by MeO group [MeO(CH2)4Cl (II) and Br, MeOCMe2CH2Br (III), and MeOCMe2CHMeBr]. These results were attributed to differing effects on the solvent shell, resulting from involvement of the intramol. nucleophiles. In addition to b.p. and nD of compounds studied, the following new preparations were reported (compound, b.p., n25D, and reagents used in preparation): HOCH2CH2I, 88° (30 mm.), 1.5625, NaI and HOCH2CH2Cl; MeO(CH2)3Br (IV), 129°, 1.4448 (26°), NaOMe and Br(CH2)3Br; MeO(CH2)3I, 155-8°, 1.4873 (27°), NaI and IV; I, 56° (40 mm.), 1.4260, Me2C:CH2 and HOCl in aqueous AcOH; II, 48-53° (20 mm.), 1.4290, NaOMe and Cl(CH2)4Cl; MeOCH2CMe2Cl, 88-90°, 1.4039 (24°), corresponding alc.; III, -, 1.4575, Me2C:CH2 and methanolic N-bromosuccinimide. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Related Products of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary