Marcinkowska, Monika et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2019 | CAS: 954-81-4

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Anti-Alzheimer’s multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity was written by Marcinkowska, Monika;Bucki, Adam;Panek, Dawid;Siwek, Agata;Fajkis, Nikola;Bednarski, Marek;Zygmunt, Malgorzata;Godyn, Justyna;Del Rio Valdivieso, Alvaro;Kotanska, Magdalena;Kolaczkowski, Marcin;Wieckowska, Anna. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Category: bromides-buliding-blocks This article mentions the following:

Serotonin 5-HT6 receptors, butyrylcholinesterase (BuChE) and oxidative stress are related to the pathophysiol. of Alzheimer’s disease. Inhibition of BuChE provides symptomatic treatment of the disease and the same effect was demonstrated for 5-HT6 antagonists in clin. trials. Oxidative stress is regarded as a major and primary factor contributing to the development of Alzheimer’s disease; therefore, antioxidant agents may provide a disease-modifying effect. Combining BuChE inhibition, 5-HT6 antagonism, and antioxidant properties may result in multitarget-directed ligands providing cognition-enhancing properties with neuroprotective activity. On the basis of the screening of the library of 5-HT6 antagonists against BuChE, we selected two compounds and designed their structural modifications that could lead to improved BuChE inhibitory activity. We synthesized two series of compounds and tested their affinity and functional activity at 5-HT6 receptors, BuChE inhibitory activity and antioxidant properties. Compound 12(I) with Ki and Kb values against 5-HT6 receptors of 41.8 and 74 nM, resp., an IC50 value of 5 μM against BuChE and antioxidant properties exceeding the activity of ascorbic acid is a promising lead structure for further development of anti-Alzheimer’s agents. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Category: bromides-buliding-blocks).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary