3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase was written by Noe, Mark C.;Snow, Sheri L.;Wolf-Gouveia, Lilli A.;Mitchell, Peter G.;Lopresti-Morrow, Lori;Reeves, Lisa M.;Yocum, Sue A.;Liras, Jennifer L.;Vaughn, Marcie. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Computed Properties of C9H11Br This article mentions the following:
N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochem. properties and low metabolic clearance. Synthesis and structure-activity relationships are reported. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Computed Properties of C9H11Br).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C9H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary