A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential C-H Functionalization was written by Pitts, Andrew K.;O’Hara, Fionn;Snell, Robert H.;Gaunt, Matthew J.. And the article was included in Angewandte Chemie, International Edition in 2015.Electric Literature of C9H11BrO This article mentions the following:
A sequential C-H functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B (I.NH3) is reported. Our synthesis begins from com. available 4-bromoindole and involves six direct functionalizations around the heteroarene core as part of a gram-scale strategy towards the natural product. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary