New Concise and Efficient Synthesis of Rubrolides C and E via Intramolecular Wittig Reaction was written by Tale, Nilesh P.;Shelke, Amol V.;Tiwari, Girdharilal B.;Thorat, Prerana B.;Karade, Nandkishor N.. And the article was included in Helvetica Chimica Acta in 2012.Recommanded Product: 108940-96-1 This article mentions the following:
A short total synthesis of rubrolides C (I) and E (II) has been achieved in four steps, using readily available 4-methoxyacetophenone, 2-bromoacetic acid, and the appropriate aromatic aldehyde, in 46 and 45% yield, resp. Key reactions involved are α-tosyloxylation of the aryl Me ketone, intramol. Wittig reaction, Knoevenagel condensation, and demethylation. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Recommanded Product: 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary