Copper-catalyzed endo-type trifluoromethylarylation of alkynes was written by Xu, Jun;Wang, Yun-Long;Gong, Tian-Jun;Xiao, Bin;Fu, Yao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Product Details of 14425-64-0 This article mentions the following:
A new copper-catalyzed trifluoromethylarylation reaction of alkynes has been developed. The transformation represents the first example of endo-type carbotrifluoromethylation of unsaturated carbon-carbon bonds and provides efficient access to a variety of CF3-substituted dihydronaphthalenes and chromenes. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Product Details of 14425-64-0).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Product Details of 14425-64-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary