Synthesis of (S)-2,6-dimethylphenylalanine via Ni(II) chelate induction was written by Zhang, Liang;Hou, Wenjie;Li, Ziyuan;Bai, Longxiang;Li, Tingyou. And the article was included in Xibei Yaoxue Zazhi in 2014.Name: 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:
The paper is to synthesize the unnatural amino acid (S)-2,6-dimethylphenylalanine. 2,6-Dimethylbenzoic acid was reduced to produce 2,6-dimethylbenzyl alc., then the 2,6-dimethylbenzyl alc. was brominated to generate 2,6-dimethylbenzyl bromide. The 2,6-dimethylbenzyl bromide was then coupled with (S)-BPB-Ni-Gly complex to give (S)-Dmp-BPB-Ni complex, which was then decomposed by acid to obtain (S)-2,6-dimethylphenylalanine. (S)-2,6-Dimethylphenylalanine was synthesized with a total yield of 33.6%. This method has characteristics of cheap starting materials and simple exptl. procedure. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Name: 2-(Bromomethyl)-1,3-dimethylbenzene).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Name: 2-(Bromomethyl)-1,3-dimethylbenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary