Catalytic enantioselective desymmetrizing functionalization of alkyl radicals via Cu(I)/CPA cooperative catalysis was written by Cheng, Yong-Feng;Liu, Ji-Ren;Gu, Qiang-Shuai;Yu, Zhang-Long;Wang, Jian;Li, Zhong-Liang;Bian, Jun-Qian;Wen, Han-Tao;Wang, Xiao-Jing;Hong, Xin;Liu, Xin-Yuan. And the article was included in Nature Catalysis in 2020.Synthetic Route of C10H11BrO2 This article mentions the following:
A general and efficient catalytic enantioselective desymmetrizing functionalization of alkene-tethered 1,3-diols was developed. It provided various tetrahydrofurans and analogs such as I [R1 = H, 3-furyl, 4-BrC6H4, etc.; R2 = 3-MeOC6H4, 3-furyl, 1-naphthyl, etc.; R3 = CF3, n-C4F9] bearing multiple stereocenters with remarkably high levels of enantio- and diastereocontrol. DFT calculations and mechanistic experiments revealed a reaction mechanism involving an enantiodetermining outer-sphere C-O bond formation step. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Synthetic Route of C10H11BrO2).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C10H11BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary