Total Synthesis of (-)-Blepharocalyxin D and Analogues was written by Cons, Benjamin D.;Bunt, Adam J.;Bailey, Christopher D.;Willis, Christine L.. And the article was included in Organic Letters in 2013.Formula: C9H11BrO This article mentions the following:
An efficient strategy for the total synthesis of (-)-blepharocalyxin D and an analog is described. The key step involves an acid-mediated cascade process in which reaction of Me 3,3-dimethoxypropanoate with γ,δ-unsaturated alcs. possessing diastereotopic styrenyl groups gives trans-fused bicyclic lactones with the creation of two rings and four stereocenters in one pot. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Formula: C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Formula: C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary