8-Substituted pteridines was written by Dick, G. P. G.;Fidler, W. E.;Wood, H. C. S.. And the article was included in Chemistry & Industry (London, United Kingdom) in 1956.Electric Literature of C5H11BrO This article mentions the following:
Preparations of 8-substituted pteridines from pyrazine intermediates were studied. 2-Hydroxy-3-methoxycarbonylpyrazine in Me2CO solution with MeI in the presence of K2CO3 gave 1,2-dihydro-3-methoxycarbonyl-1-methyl-2-oxopyrazine (I). I with guanidine carbonate in aqueous MeOH gave a salt of guanidine and 1,2-dihydro-1-methyl-2-oxopyrazine-3-carboxylic acid, which had phys. properties similar to those expected for 2,8-dihydro-4-hydroxy-2-imino-8-methylpteridine. Fusion of 1,2-dihydro-3-methoxycarbonyl-1-methyl-2-oxo-5,6-diphenylpyrazine with guanidine carbonate gave 93% 2,8-dihydro-4-hydroxy-2-imino-8-methyl-6,7-diphenylpteridine. This method is applicable to preparations of pteridines with a sugar group at the 8 position. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Electric Literature of C5H11BrO).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C5H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary