Selective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage Progression was written by Gacias, Mar;Gerona-Navarro, Guillermo;Plotnikov, Alexander N.;Zhang, Guangtao;Zeng, Lei;Kaur, Jasbir;Moy, Gregory;Rusinova, Elena;Rodriguez, Yoel;Matikainen, Bridget;Vincek, Adam;Joshua, Jennifer;Casaccia, Patrizia;Zhou, Ming-Ming. And the article was included in Chemistry & Biology (Oxford, United Kingdom) in 2014.COA of Formula: C13H14BrNO2 This article mentions the following:
Lysine acetylation regulates gene expression through modulating protein-protein interactions in chromatin. Chem. inhibition of acetyl-lysine binding bromodomains of the major chromatin regulators BET (bromodomain and extraterminal domain) proteins has been shown to effectively block cell proliferation in cancer and inflammation. However, whether selective inhibition of individual BET bromodomains has distinctive functional consequences remains only partially understood. In this study, we show that selective chem. inhibition of the first bromodomain of BET proteins using our small-mol. inhibitor, Olinone, accelerated the progression of mouse primary oligodendrocyte progenitors toward differentiation, whereas inhibition of both bromodomains of BET proteins hindered differentiation. This effect was target specific, as it was not detected in cells treated with inactive analogs and independent of any effect on proliferation. Therefore, selective chem. modulation of individual bromodomains, rather than use of broad-based inhibitors, may enhance regenerative strategies in disorders characterized by myelin loss such as aging and neurodegeneration. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4COA of Formula: C13H14BrNO2).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. COA of Formula: C13H14BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary