Aromatic esters which inhibit plasmin or thrombin by formation of relatively stable acyl enzymes was written by Glover, George;Wang, Chih-Cheng;Shaw, Elliott. And the article was included in Journal of Medicinal Chemistry in 1973.Computed Properties of C8H7BrO2 This article mentions the following:
Selective inhibition of plasmin [9001-90-5] and thrombin [9002-04-4] (both serine proteinases of trypsinlike specificity) was possible with nitrophenyl esters of benzoic acid carrying pos. charged substituents such as sulfonium, isothiuronium, and pyridinium. Inhibition resulted from formation of a moderately stable, inactive, covalent intermediate (acyl enzyme). Para substitution favored selective inhibition of plasmin which was more susceptible than thrombin to this type of inactivation. Thus, p-nitrophenyl p-[(4-benzylpyridinium)methyl]benzoate (I) [40026-23-1] at 2 .tim. 10-5 M inhibited plasmin by 90% but did not inhibit thrombin. Certain meta-substituted derivatives converted thrombin to the acyl enzyme more extensively than plasmin; thus, p-nitrophenyl m-[[(N-methylamidino)thio]methyl]benzoate (II) [40081-68-3] inhibited thrombin by 41% but plasmin only by 6%. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Computed Properties of C8H7BrO2).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C8H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary