Efficient Assembly of Molecular Complexity Enabled by Palladium-Catalyzed Heck Coupling/C(sp2)-H Activation/ C(sp3)-H Activation Cascade was written by He, Chen;Han, Wen-Yong;Cui, Bao-Dong;Wan, Nan-Wei;Chen, Yong-Zheng. And the article was included in Advanced Synthesis & Catalysis in 2020.Recommanded Product: 83902-02-7 This article mentions the following:
A palladium-catalyzed [2+2+1] annulation among 3-iodochromones, benzyl bromides, and norbornene has been developed. This annulation consists of a domino sequence involving Heck coupling/C(sp2)-H activation/C(sp3)-H activation, affording a variety of complex chromone derivatives I (R = H, 6-Me, 7-F, etc.; R1 = C6H5, 3-MeC6H4, 4-FC6H4, etc.) bearing five contiguous tertiary carbon centers in up to 94% yield and 99:1 dr. Interestingly, the diastereoselectivity could be switched by fine-tuning the solvent, in which endo isomer and exo isomer were obtained using mesitylene/CH3CN and mesitylene, resp. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Recommanded Product: 83902-02-7).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 83902-02-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary