One-Pot Base-Mediated Synthesis of Functionalized Aza-Fused Polycyclic Quinoline Derivatives was written by Jiang, Zeng-qiang;Miao, Da-zhuang;Tong, Yao;Pan, Qiang;Li, Xiao-tong;Hu, Ren-he;Han, Shi-qing. And the article was included in Synthesis in 2015.Electric Literature of C10H11BrO2 This article mentions the following:
A new one-pot protocol has been developed for a facile and efficient synthesis of aza-fused polycyclic quinolines (e.g., pyrrolo[1,2-a]quinoline derivatives) by a base-catalyzed reaction of 2-formylpyrrole with and (2-halophenyl)acetonitrile derivatives This reaction proceeded under transition metal-free conditions and showed high functional group tolerance, with the desired products being formed in good yield. Under optimized conditions the synthesis of the target compounds was achieved using phosphoric acid potassium salt (1:3) (potassium phosphate) and DMSO as reagent-solvent combination. Starting materials included 2-(bromo)benzeneacetonitrile, 2-(iodo)benzeneacetonitrile, 2-(chloro)benzeneacetonitrile, 2-(chloro)benzeneacetic acid ester as nitrile components. Aldehydes included 1H-pyrrole-2-carboxaldehyde, 1H-indole-2-carboxaldehyde derivatives, 1H-imidazole-2-carboxaldehyde derivatives The title compounds thus formed included pyrrolo[1,2-a]quinoline derivatives and imidazo[1,2-a]quinoline derivatives (nitriles, carboxylic acid esters). In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Electric Literature of C10H11BrO2).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C10H11BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary