Late-Stage Bromination Enables the Synthesis of Rubrolides B, I, K, and O was written by Karak, Milandip;Acosta, Jaime A. M.;Barbosa, Luiz C. A.;Boukouvalas, John. And the article was included in European Journal of Organic Chemistry in 2016.Category: bromides-buliding-blocks This article mentions the following:
A concise and efficient synthesis of the marine natural products rubrolides B (I), I (II), K (III), and O (IV) was accomplished in 3-4 steps from com. available 3,4-dichloro-2(5H)-furanone. Key steps include: (i) a site-selective Suzuki cross-coupling, (ii) a vinylogous aldol condensation, and (iii) a late-stage bromination. The latter reaction allowed functionalization of the aromatic rings in a highly regioselective fashion, enabling rapid access to the target rubrolides from common precursors. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Category: bromides-buliding-blocks).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary