Insight into the Reactivity Profile of Solid-State Aryl Bromides in Suzuki-Miyaura Cross-Coupling Reactions Using Ball Milling was written by Kubota, Koji;Kondo, Keisuke;Seo, Tamae;Ito, Hajime. And the article was included in Synlett in 2022.COA of Formula: C16H17Br This article mentions the following:
Despite recent advances in solid-state organic synthesis using ball milling, insight into the unique reactivity of solid-state substrates, which is often different from that in solution, has been poorly explored. In this study, author’s investigated the relationship between the reactivity and m.ps. of aryl halides in solid-state Suzuki-Miyaura cross-coupling reactions and the effect of reaction temperature on these processes. Author’s found that aryl halides with high m.ps. showed significantly low reactivity in the solid-state cross-coupling near room temperature, but the reactions were notably accelerated by increasing the reaction temperature Given that the reaction temperature is much lower than the m.ps. of these substrates, the acceleration effect is most likely ascribed to the weakening of the intermol. interactions between the substrate mols. in the solid state. The present study provides important perspectives for the rational design of efficient solid-state organic transformations using ball milling. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1COA of Formula: C16H17Br).
4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.COA of Formula: C16H17Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary