Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity was written by Li, Jia-Cheng;Zhang, Juan;Rodrigues, Mosar Correa;Ding, De-Jun;Longo, Joao Paulo Figueiro;Azevedo, Ricardo Bentes;Muehlmann, Luis Alexandre;Jiang, Cheng-Shi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Application of 61150-57-0 This article mentions the following:
A series of new 1,2,3-triazole derivatives were synthesized and evaluated for anticholinesterase and neuroprotective activities. Some synthetic derivatives, especially compound I, exhibited improved acetylcholinesterase (AChE) inhibitory activity by comparison with the hit, high selectivity toward AChE over butyrylcholinesterase (BuChE), and suitable in vitro neuroprotective effect against amyloid-β25-35 (Aβ25-35)-induced neurotoxicity in SH-SY5Y cells. Furthermore, these mols. have desired physicochem. properties in the range of CNS drugs and showed no cytotoxicity against two normal cells, including human keratinocytes HaCaT and murine fibroblasts NIH-3T3. The preliminary bioassay results and docking study indicated that compound I might be a promising lead compound with dual action for the treatment of Alzheimer’s disease. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Application of 61150-57-0).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 61150-57-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary