Practical, Highly Convergent, Asymmetric Synthesis of a Selective PPARγ Modulator was written by Maligres, Peter E.;Humphrey, Guy R.;Marcoux, Jean-Francois;Hillier, Michael C.;Zhao, Dalian;Krska, Shane;Grabowski, Edward J. J.. And the article was included in Organic Process Research & Development in 2009.Related Products of 95668-20-5 This article mentions the following:
A practical, highly convergent, asym. synthesis of a selective PPARγ modulator (I) is described. The inhibitor contains two key components, a 6-trifluoromethoxy-3-acylindole (II) and (R)-α-aryloxybutanoic acid derivative (10). Two methods were developed to overcome the regioselectivity issues encountered in the preparation of the II-substituted indole. The first involved an intramol. Heck reaction of an iodoaryl enamine. The second involved application of a catalytic Meerwein arylation reaction between 2-nitro-4-trifluoromethoxyaniline and isopropenyl acetate and subsequent reductive cyclization. The α-aryloxybutanoic acid was prepared via an asym. hydrogenation of the corresponding α-aryloxy-α,β-unsaturated acid. Tetrabutylammonium iodide-catalyzed coupling of the two fragments and ester hydrolysis completed the convergent synthesis. The described convergent synthesis was used to prepare >3 kg of drug substance I in 50% overall yield and with >99.5% ee. In the experiment, the researchers used many compounds, for example, 3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5Related Products of 95668-20-5).
3-Nitro-4-(trifluoromethoxy)bromobenzene (cas: 95668-20-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 95668-20-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary