Vinylogous Nitro-Haloform Reaction Enables Aromatic Amination was written by Monasterolo, Claudio;Adamo, Mauro F. A.. And the article was included in Organic Letters in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:
The first example of an aromatic haloform reaction was reported, defining a conceptually new haloform-type approach to the metal-free functionalization of arenes I [R1 = Ph, i-Pr, cyclobutane, etc.; R 2 = H; R1R2 = -(CH2)4-, -(CH2)5-, -(CH2)2O- (CH2)2, etc.]. The heteroarenes bearing a vinylogous nitromethane system, via the stage of a trichloromethane derivative II, could undergo aromatic amination to produce N-functionalized arenes I in quant. yields and without the need for transition-metal catalysis. The haloform-type amination was implemented in the development of effective orthogonal N-protection strategies, establishing a new promising N-protecting reagent. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).
1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary