Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents was written by Murugesan, Dinakaran;Kaiser, Marcel;White, Karen L.;Norval, Suzanne;Riley, Jennifer;Wyatt, Paul G.;Charman, Susan A.;Read, Kevin D.;Yeates, Clive;Gilbert, Ian H.. And the article was included in ChemMedChem in 2013.COA of Formula: C9H11BrO This article mentions the following:
Previously reported pyrrolones, such as TDR32570 (I), exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility and metabolic instability. Here, further structure-activity relationship studies are described that aimed to solve the developability issues associated with this series of compounds In particular, further modifications to the lead pyrrolone, involving replacement of a Ph ring with a piperidine and removal of a potentially metabolically labile ester by a scaffold hop, gave rise to derivatives with improved in vitro antimalarial activities against Plasmodium falciparum K1, a chloroquine- and pyrimethamine-resistant parasite strain, with some derivatives exhibiting good selectivity for parasite over mammalian (L6) cells. Three representative compounds were selected for evaluation in a rodent model of malaria infection, and the best compound showed improved ability to decrease parasitemia and a slight increase in survival. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0COA of Formula: C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary