A new synthesis of arylacetic esters starting from aromatic aldehyde by the use of methyl (methylthio)methyl sulfoxide was written by Ogura, Katsuyuki;Ito, Yoko;Tsuchihashi, Genichi. And the article was included in Bulletin of the Chemical Society of Japan in 1979.Safety of Ethyl (2-bromophenyl)acetate This article mentions the following:
Me (methylthio)methyl sulfoxide reacted with BzH in the presence of benzyltrimethylammonium hydroxide (Triton B), NaOH, or KOH, affording 1-(methylsulfinyl)-1-(methylthio)-2-phenylethylene. Treatment of this product with HCl in an alc. gave the corresponding alkyl phenylacetate in high yield. The whole reaction sequence provides a new method for synthesizing penylacetic esters starting from BzH. In a similar manner, (alkoxy-, halo-, or alkyl-substituted phenyl)acetic esters were synthesized from the corresponding aromatic aldehydes. The present method is also applicable to the production of (2-thienyl)acetic esters. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Safety of Ethyl (2-bromophenyl)acetate).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of Ethyl (2-bromophenyl)acetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary