Novel squaramides with in vitro liver stage antiplasmodial activity was written by Ribeiro, Carlos J. A.;Espadinha, Margarida;Machado, Marta;Gut, Jiri;Goncalves, Lidia M.;Rosenthal, Philip J.;Prudencio, Miguel;Moreira, Rui;Santos, Maria M. M.. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Related Products of 954-81-4 This article mentions the following:
A structure-activity relationship study was performed with ten 8-aminoquinoline-squaramides compounds active against liver stage malaria parasites, using human hepatoma cells (Huh7) infected by Plasmodium berghei parasites. In addition, their blood-schizontocidal activity was assessed against chloroquine-resistant W2 strain Plasmodium falciparum. Compound I was 7.3-fold more potent than the pos. control primaquine against liver-stage parasites, illustrating the importance of the squarate moiety to activity. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 954-81-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary