Benzoxazinones as PPARγ Agonists. 2. SAR of the Amide Substituent and In Vivo Results in a Type 2 Diabetes Model was written by Rybczynski, Philip J.;Zeck, Roxanne E.;Dudash, Joseph Jr.;Combs, Donald W.;Burris, Thomas P.;Yang, Maria;Osborne, Melville C.;Chen, Xiaoli;Demarest, Keith T.. And the article was included in Journal of Medicinal Chemistry in 2004.Name: 1-Bromo-4-methoxybutane This article mentions the following:
A series of benzoxazinones I [R = Me, n-decyl, 2-cyclopentylethyl, HOCH2CH2, H2NCO(CH2)4, MeCF2(CH2)4, EtO(CH2)3, etc.] has been synthesized and tested for PPARγ agonist activity (PPAR = peroxisome proliferator-activated receptor). Synthetic approaches were developed to provide either racemic or chiral compounds In vitro functional potency could be measured through induction of the aP2 gene, a target of PPARγ. These studies revealed that compounds I with large aliphatic chains at the nitrogen of the benzoxazinone ring are the most potent. Substitution of the chain was tolerated and in many cases enhanced the in vitro potency of the compound Select compounds were further tested for metabolic stability, oral bioavailability in rats, and efficacy in db/db mice after 11 days of dosing. In vivo anal. with optically active (R)-I [R = n-hexyl, MeO(CH2)4] demonstrated that the series has potential for the treatment of type 2 diabetes. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 1-Bromo-4-methoxybutane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary