Rh(III)-Catalyzed Phosphine Oxide Migration Reactions: Selective Synthesis of 3-Phosphinoylindoles was written by Wang, Chun-Hai;Yang, Shang-Dong. And the article was included in Chemistry – An Asian Journal in 2018.Formula: C8H4BrF3O This article mentions the following:
3-Phosphinoylindoles are important components of biol. active natural products and materials in pharmaceuticals. Herein, a new approach for the synthesis of 3-phosphinoylindoles was established by a Rh(III)-catalyzed cyclization from readily accessible (2-azidostyryl)diphenylphosphine oxides. This intramol. transformation occurs through a unique phosphine oxide group migration and offers a straightforward route to rebuild sp2 C-P bond and construct the indole ring in single step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Formula: C8H4BrF3O).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C8H4BrF3O
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary